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MiR-345-5p was a tumor-suppressive miRNA in pancreatic cancer progression by targeting CCL8.
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It was shown that MCP2 was able to activate the NF-kappaB signaling pathway inducing the epithelial-mesenchymal transition (EMT) and promoting the migration and invasion of ESCC cells in vitro.
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Transcriptome analysis identified several novel IPF-related genes. Among them, CCL8 is a candidate molecule for the differential diagnosis and prediction of survival.
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Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.
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Detecting expression changes in TLR4 and MCP2 in the peripheral blood is a feasible method for predicting the occurrence of abortion in women of child-bearing age
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Dermal fibroblast CCL8 promotes melanoma metastasis.
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Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.
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CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.
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JAK2 and STAT3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis.
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Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway.
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Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.
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genetic polymorphhism is associated with a risk of death for non-small cell lung cancer in Chinese
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Cytokine treatment increases mRNA stability only for chemokines CCL2 and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine CCL2 and CCL8 expression in primary and transformed epithelial cells.
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CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induced secretion of MCP-2 chemokine
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TRAIL pretreatment of endothelial cells down-modulated mRNA steady-state levels of several TNF-alpha-induced chemokines, and it abrogated the TNF-alpha-mediated up-regulation of CCL8 and CXCL10, modulating leukocyte/endothelial cell adhesion
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Angiotensin II directly stimulates MCP-2 expression through AT1-receptors in activated macrophages
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CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease.
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A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS.
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MMP-12 truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists
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IP-10 and MCP-2 are expressed in tuberculosis patients