Chemokine (C-C Motif) Ligand 8 Protéines (CCL8)

Human Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

1. MiR-345-5p was a tumor-suppressive miRNA in pancreatic cancer progression by targeting CCL8.

2. It was shown that MCP2 was able to activate the NF-kappaB signaling pathway inducing the epithelial-mesenchymal transition (EMT) and promoting the migration and invasion of ESCC cells in vitro.

3. Transcriptome analysis identified several novel IPF-related genes. Among them, CCL8 is a candidate molecule for the differential diagnosis and prediction of survival.

4. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.

5. Detecting expression changes in TLR4 and MCP2 in the peripheral blood is a feasible method for predicting the occurrence of abortion in women of child-bearing age

6. Dermal fibroblast CCL8 promotes melanoma metastasis.

7. Authors show that the previously observed downregulation of hsa-miR-92a and upregulation of CCL8 during human cytomegalovirus latent infection of myeloid cells are intimately linked via the latency-associated expression of cytomegalovirus UL111A.

8. CCL8 is an antimicrobial protein with bacteriocidal activity against E. coli.

9. JAK2 and STAT3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis.

10. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway.

11. Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls.

12. genetic polymorphhism is associated with a risk of death for non-small cell lung cancer in Chinese

13. Cytokine treatment increases mRNA stability only for chemokines CCL2 and CCL8 in airway epithelium, and transient silencing and overexpression of human antigen R affects only chemokine CCL2 and CCL8 expression in primary and transformed epithelial cells.

14. CCL8/MCP-2 is a target for mir-146a in HIV-1 infected microglia, as overexpression of mir-146a prevented HIV-induced secretion of MCP-2 chemokine

15. TRAIL pretreatment of endothelial cells down-modulated mRNA steady-state levels of several TNF-alpha-induced chemokines, and it abrogated the TNF-alpha-mediated up-regulation of CCL8 and CXCL10, modulating leukocyte/endothelial cell adhesion

16. Angiotensin II directly stimulates MCP-2 expression through AT1-receptors in activated macrophages

17. CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease.

18. A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS.

19. MMP-12 truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists

20. IP-10 and MCP-2 are expressed in tuberculosis patients

Mouse (Murine) Chemokine (C-C Motif) Ligand 8 (CCL8) interaction partners

1. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.

2. tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells

3. these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8.

4. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway.

5. Data indicate mRNA upregulation of CCR2 and CCR2 ligands CCL2, CCL7, CCL8, and CCL12 in aortas from DOCA/salt-treated hypertension.

6. Vitamin B6 supplementation downregulates Cd8a and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development.

7. early and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology.

8. MCP/CCL8 was induced via STAT3 and exhibited anti-tumor metastatic effect

9. promotes atopic dermatitis by recruiting IL-5+ Th2 cells

10. CCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

11. Data show that that the stromal cell-derived chemokines CXCL12 and CCL8 cooperate to attract hematopoietic progenitors with the potential to differentiate into regulatory DCs.

12. CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease.

13. MMP-12 truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists

14. An elevated plasma CCL8 concentration may be a promising plasma marker for GVHD in mouse models