anti-Chemokine (C-C Motif) Receptor 4 (CCR4) Anticorps

The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . De plus, nous expédions CCR4 Kits (18) et CCR4 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CCR4 1233 P51679
CCR4 12773 P51680
CCR4 171054  
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Showing 10 out of 155 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Souris Lapin Inconjugué WB Anti-CCR4 antibody, Western blotting All lanes: Anti CCR4  at 0.5ug/ml Lane 1: Rat Thymus Tissue Lysate at 50ug Lane 2: Rat Spleen Tissue Lysate at 50ug Lane 3: HEPA Whole Cell Lysate at 40ug Predicted bind size: 41KD Observed bind size: 41KD 100 μg 4 to 6 Days
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-CCR4 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate CCR4 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of CCR4 expression in HL60 (A), MCF7 (B) whole cell lysates. 200 μL 13 to 14 Days
Chien Lapin Inconjugué WB Western blot analysis of CCR4 expression in HEK293T (A), NIH3T3 (B) whole cell lysates. 200 μL 13 to 14 Days
Chien Lapin Inconjugué WB Western blot analysis of CCR4 using Jurkat cell lysates. 100 μg 2 to 3 Days
Humain Lapin Inconjugué IF (p), IHC (p) Formalin-fixed and paraffin embedded rat exfoliated cells tissue labeled with Anti-CCR4 Polyclonal Antibody, Unconjugated (ABIN738666) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat cells labeled with Anti-CCR4/CD194 Polyclonal Antibody, Unconjugated (ABIN738666) followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Humain Lapin Inconjugué IF, ELISA Immunofluorescence analysis of HuvEc cells, using CCR4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Humain Souris Inconjugué cELISA, FACS FACS analysis of BOSC23 cells using KH-4F5. BOSC23 cells were transientlytransfected with an expression vector encodingeither CCR4 (red curve) or an irrelevant protein(control transfectant). Binding of KH-4F5 was detected with a PE conjugated secondary antibody. A positive signal was obtained only with CCR4 transfected cells. Spectral Confocal Microscopy of CHO cells using KH-4F5. CHO cells were transiently transfected with an expression vector encoding CCR4. Binding of KH-4F5 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with A 100 μg 6 to 7 Days
Humain Lapin Inconjugué WB Western blot analysis of CCR4 using anti-CCR4 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat thymus tissue lysates, Lane 2: mouse thymus tissue lysates, Lane 3: mouse NIH3T3 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CCR4 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CCR4 at approximately 41KD. The expected band size for CCR4 is at 41KD. 100 μg 4 to 6 Days
Humain Chèvre Inconjugué ELISA, FACS, IHC, IHC (p), WB Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days

anti-CCR4 Anticorps mieux référencés

  1. Human Monoclonal CCR4 Primary Antibody pour CyTOF, FACS - ABIN4899090 : Aruga, Takeshita, Kotera, Okuyama, Matsushita, Ohta, Takeda, Yamamoto: Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2013 (PubMed)
    Show all 12 Pubmed References

  2. Human Monoclonal CCR4 Primary Antibody pour FACS - ABIN4895505 : Aruga, Takeshita, Kotera, Okuyama, Matsushita, Ohta, Takeda, Yamamoto: Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer. dans Journal of translational medicine 2014 (PubMed)
    Show all 11 Pubmed References

  3. Human Monoclonal CCR4 Primary Antibody pour FACS - ABIN2689051 : Bonecchi, Bianchi, Bordignon, DAmbrosio, Lang, Borsatti, Sozzani, Allavena, Gray, Mantovani, Sinigaglia: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. dans The Journal of experimental medicine 1998 (PubMed)
    Show all 9 Pubmed References

  4. Human Monoclonal CCR4 Primary Antibody pour FACS - ABIN4895502 : James, Gates, LaFond, Yamamoto, Ni, Mai, Gersuk, OBrien, Nguyen, Zeitner, Lanteri, Norris, Chaussabel, Malhotra, Kwok: Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. dans PLoS pathogens 2016 (PubMed)
    Show all 7 Pubmed References

  5. Human Monoclonal CCR4 Primary Antibody pour FACS - ABIN2689052 : Campbell, Haraldsen, Pan, Rottman, Qin, Ponath, Andrew, Warnke, Ruffing, Kassam, Wu, Butcher: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. dans Nature 1999 (PubMed)
    Show all 7 Pubmed References

  6. Human Polyclonal CCR4 Primary Antibody pour ICC, FACS - ABIN152140 : Power, Meyer, Nemeth, Bacon, Hoogewerf, Proudfoot, Wells: Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. dans The Journal of biological chemistry 1995 (PubMed)
    Show all 6 Pubmed References

  7. Human Polyclonal CCR4 Primary Antibody pour WB - ABIN4289060 : Park, Roh, Kim, Kim, Han, Hong: CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes. dans Journal of applied toxicology : JAT 2013 (PubMed)
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  8. Human Monoclonal CCR4 Primary Antibody pour FACS - ABIN4895498 : Antonelli, Mahnke, Hodge, Porter, Barber, DerSimonian, Greenwald, Roby, Mican, Sher, Roederer, Sereti: Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. dans Blood 2010 (PubMed)
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  9. Human Polyclonal CCR4 Primary Antibody pour IF (p), IHC (p) - ABIN738666 : Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction. dans International journal of nanomedicine 2015 (PubMed)

  10. Mouse (Murine) Polyclonal CCR4 Primary Antibody pour ICC, FACS - ABIN152144 : Herling, Patel, Weit, Lilienthal, Hallek, Keating, Jones: High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia. dans Blood 2009 (PubMed)

Plus d’anticorps contre CCR4 partenaires d’interaction

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. The frequency of CC genotypes at both SNPs rs4359426 and rs2228428 in C-C motif chemokine 22 (CCL22) and chemokine (C-C motif) receptor 4 protein (CCR4) genes was significantly higher in myocardial infarction (MI) patients compared to other genotypes.

  2. CCR4(+) rather than CLA(+) is the predominant phenotype in peanut-allergic subjects.

  3. CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.

  4. Findings suggest that C-C motif chemokine receptor 4 (CCR4) may be a potential new diagnostic and prognostic marker in hepatocellular carcinoma (HCC), and targeting CCR4 may be a potential therapeutic option for blocking HCC metastasis

  5. REVIEW: Ccr4-Not Complex: Architecture and Structural Insights

  6. Study suggests that the immunohistochemical expression of CCR4 may potentially be used as an additional tool in the differential diagnosis between epidermotropic primary cutaneous gamma/delta (gammadelta) T cell lymphomas (PCgammadeltaTCL) and mycosis fungoides (MF). Lack of expression of CCR4 in PCgammadeltaTCL may indicate that these patients are not ideal candidates for therapy with mogamulizumab.

  7. Data show that a high ratio of C-C motif chemokine receptor 4 (CCR4(+)) tumor-infiltrating effector regulatory T cells (eTregs) to total Tregs was the only independent risk factor for relapse-free survival.

  8. CAF1 and CCR4, catalytic subunits of CNOT, display distinct activities: CAF1 trims naked poly(A) segments and is blocked by PABPC, whereas CCR4 is activated by PABPC to shorten PABPC-protected sequences.

  9. MACs from Familial hypercholesterolemia (FH)-MACs have an inflammatory phenotype that is characterized by the up-regulation of CCR3, CCR4, and CXCR1 under the control of miR-505-3p. These results suggest a chronic inflammatory condition in FH innate immunity cells that is not reverted by standard lipid-lowering treatment

  10. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

  11. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review]

  12. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 production in ectopic milieu. The high levels of IL-6 in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK signal pathway, and then, CCL17 further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 production via NF-kappaB activation.

  13. Investigations showed that the level of CCR4 could be induced by TNF-alpha dependent of NF-kappaB activation in CRC cells. CCR4 might be implicated in TNF-alpha-regulated cancer cells metastasis.

  14. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 signaling axis.

  15. monocyte chemoattractant protein-1 (MCP-1), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands

  16. Chemokine receptors CCR3 and CCR4, and the mucosa specific chemokine CCL28 have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 and HGF and reducing the secretion of TIMP-1.

  17. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  18. The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  19. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8-positive T-cell mediated dermatitis.

  20. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. CKLF1 is an important mediator that skewing microglia/macrophage toward M1 phenotype at early stage of cerebral ischemic injury

  2. findings suggest that CD4(+)Foxp3(+) cells play a time-dependent role in tuberculosis and highlight that CCR4 plays a critical role in the balance of IFN-gamma-mediated inflammation by regulating the influx and function of CD4(+)Foxp3(+) cells.

  3. CCR4 role in the Th2 cells chemotaxis.

  4. Malaria-associated acute respiratory distress syndrome was dependent on functional CCR4, known to mediate the recruitment of Th2 lymphocytes and regulatory T cells.

  5. Using atopic dermatitis model in BALB/c mice, study demonstrated that Ccr4-deficiency or a Ccr4 antagonist ameliorated the allergic responses. Collectively, these results demonstrate that Ccr4 plays a pivotal role in skin allergic inflammation of BALB/c mice by recruiting Ccr4-expressing Th2 cells and Th17 cells.

  6. The use of a small molecule CCR4 antagonist to prevent Tregs induction.

  7. data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors

  8. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  9. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8+ effector T cells in mice bearing B16 melanoma.

  10. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

  11. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  12. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

  13. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  14. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

  15. that effective engagement of CCR4 by CCL17 involves two distinct binding domains and interaction with both is required for signaling

  16. NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

  17. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.

  18. CCR4 promotes natural killer cell priming/activation by mediating contacts with sentinel cells in the lung.

  19. Combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 and CCR4 identifies distinct stages in the development of multiple alphabetaT cell lineages in the adult thymus.

  20. CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes.

CCR4 profil antigène

Profil protéine

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene names and symbols associated with CCR4

  • C-C motif chemokine receptor 4 (CCR4) anticorps
  • C-C motif chemokine receptor 4 (Ccr4) anticorps
  • chemokine (C-C motif) receptor 4 (Ccr4) anticorps
  • C-C CKR-4 anticorps
  • CC-CKR-4 anticorps
  • Ccr4 anticorps
  • CD194 anticorps
  • CHEMR1 anticorps
  • ChemR13 anticorps
  • CKR4 anticorps
  • Cmkbr4 anticorps
  • HGCN:14099 anticorps
  • K5-5 anticorps
  • LESTR anticorps
  • Sdf1r anticorps

Protein level used designations for CCR4

C-C CKR-4 , C-C chemokine receptor type 4 , CCR-4 , chemokine (C-C) receptor 4 , chemokine (C-C motif) receptor 4 , C-C chemokine receptor type 4-like , c-C chemokine receptor type 4-like , nocturnin , CC-chemokine receptor 4 , fusin , leukocyte-expressed seven-transmembrane-domain receptor , CC chemokine receptor 4 , CC-CKR-4 , C-C chemokine receptor 4

1233 Homo sapiens
100397096 Callithrix jacchus
100445664 Pongo abelii
100585668 Nomascus leucogenys
100379615 Cavia porcellus
12773 Mus musculus
403541 Canis lupus familiaris
408019 Bos taurus
171054 Rattus norvegicus
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