anti-Chemokine (C-C Motif) Receptor 4 (CCR4) Anticorps

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

1. The frequency of CC genotypes at both SNPs rs4359426 and rs2228428 in C-C motif chemokine 22 (CCL22) and chemokine (C-C motif) receptor 4 protein (CCR4) genes was significantly higher in myocardial infarction (MI) patients compared to other genotypes.

2. CCR4(+) rather than CLA(+) is the predominant phenotype in peanut-allergic subjects.

3. CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.

4. Findings suggest that C-C motif chemokine receptor 4 (CCR4) may be a potential new diagnostic and prognostic marker in hepatocellular carcinoma (HCC), and targeting CCR4 may be a potential therapeutic option for blocking HCC metastasis

5. REVIEW: Ccr4-Not Complex: Architecture and Structural Insights

6. Study suggests that the immunohistochemical expression of CCR4 may potentially be used as an additional tool in the differential diagnosis between epidermotropic primary cutaneous gamma/delta (gammadelta) T cell lymphomas (PCgammadeltaTCL) and mycosis fungoides (MF). Lack of expression of CCR4 in PCgammadeltaTCL may indicate that these patients are not ideal candidates for therapy with mogamulizumab.

7. Data show that a high ratio of C-C motif chemokine receptor 4 (CCR4(+)) tumor-infiltrating effector regulatory T cells (eTregs) to total Tregs was the only independent risk factor for relapse-free survival.

8. CAF1 and CCR4, catalytic subunits of CNOT, display distinct activities: CAF1 trims naked poly(A) segments and is blocked by PABPC, whereas CCR4 is activated by PABPC to shorten PABPC-protected sequences.

9. MACs from Familial hypercholesterolemia (FH)-MACs have an inflammatory phenotype that is characterized by the up-regulation of CCR3, CCR4, and CXCR1 under the control of miR-505-3p. These results suggest a chronic inflammatory condition in FH innate immunity cells that is not reverted by standard lipid-lowering treatment

10. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

11. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review]

12. Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 production in ectopic milieu. The high levels of IL-6 in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK signal pathway, and then, CCL17 further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 production via NF-kappaB activation.

13. Investigations showed that the level of CCR4 could be induced by TNF-alpha dependent of NF-kappaB activation in CRC cells. CCR4 might be implicated in TNF-alpha-regulated cancer cells metastasis.

14. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 signaling axis.

15. monocyte chemoattractant protein-1 (MCP-1), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands

16. Chemokine receptors CCR3 and CCR4, and the mucosa specific chemokine CCL28 have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 and HGF and reducing the secretion of TIMP-1.

17. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

18. The percentage of CXCR3(+) CD4(+) TEM cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA(+) CD4(+) TCM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

19. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8-positive T-cell mediated dermatitis.

20. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

1. CKLF1 is an important mediator that skewing microglia/macrophage toward M1 phenotype at early stage of cerebral ischemic injury

2. findings suggest that CD4(+)Foxp3(+) cells play a time-dependent role in tuberculosis and highlight that CCR4 plays a critical role in the balance of IFN-gamma-mediated inflammation by regulating the influx and function of CD4(+)Foxp3(+) cells.

3. CCR4 role in the Th2 cells chemotaxis.

4. Malaria-associated acute respiratory distress syndrome was dependent on functional CCR4, known to mediate the recruitment of Th2 lymphocytes and regulatory T cells.

5. Using atopic dermatitis model in BALB/c mice, study demonstrated that Ccr4-deficiency or a Ccr4 antagonist ameliorated the allergic responses. Collectively, these results demonstrate that Ccr4 plays a pivotal role in skin allergic inflammation of BALB/c mice by recruiting Ccr4-expressing Th2 cells and Th17 cells.

6. The use of a small molecule CCR4 antagonist to prevent Tregs induction.

7. data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors

8. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

9. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8+ effector T cells in mice bearing B16 melanoma.

10. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

11. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

12. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

13. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

14. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

15. that effective engagement of CCR4 by CCL17 involves two distinct binding domains and interaction with both is required for signaling

16. NF-kappaB signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

17. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.

18. CCR4 promotes natural killer cell priming/activation by mediating contacts with sentinel cells in the lung.

19. Combining a panel of thymocyte maturation markers with cell surface analysis of CCR7 and CCR4 identifies distinct stages in the development of multiple alphabetaT cell lineages in the adult thymus.

20. CCR4 and CXCR3 play different roles in the migration of T cells to inflammation in skin, arthritic joints, and lymph nodes.