Chemokine (C-C Motif) Receptor 4 Protéines (CCR4)

The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . De plus, nous expédions CCR4 Anticorps (213) et CCR4 Kits (26) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CCR4 104625 Q8K3P5
CCR4 287249 Q6AXU9
CCR4 1233 P51679
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
Wheat germ Humain Inconjugué   2 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Cat Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days

CCR4 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Rat (Rattus)
Human , ,

Plus protéines pour Chemokine (C-C Motif) Receptor 4 (CCR4) partenaires d'interaction

Mouse (Murine) Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  2. CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (Montrer CD8A Protéines)+ effector T cells in mice bearing B16 melanoma.

  3. CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.

  4. CCL22 (Montrer CCL22 Protéines) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  5. CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes

  6. results show that the IL-4 (Montrer IL4 Protéines)/CCL22 (Montrer CCL22 Protéines)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  7. These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.

  8. that effective engagement of CCR4 by CCL17 (Montrer CCL17 Protéines) involves two distinct binding domains and interaction with both is required for signaling

  9. NF-kappaB (Montrer NFKB1 Protéines) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role

  10. CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.

Human Chemokine (C-C Motif) Receptor 4 (CCR4) interaction partners

  1. Chemokine (Montrer CCL1 Protéines) receptors CCR3 (Montrer CCR3 Protéines) and CCR4, and the mucosa specific chemokine (Montrer CCL1 Protéines) CCL28 (Montrer ENC1 Protéines) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (Montrer IL6 Protéines) and HGF (Montrer HGF Protéines) and reducing the secretion of TIMP-1 (Montrer TIMP1 Protéines).

  2. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer

  3. The percentage of CXCR3 (Montrer CXCR3 Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TEM (Montrer CYLD Protéines) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (Montrer SELPLG Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TCM cells expressing CCR6 (Montrer CCR6 Protéines)(+) or CCR4(+)CXCR3 (Montrer CXCR3 Protéines)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.

  4. Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (Montrer CD8A Protéines)-positive T-cell mediated dermatitis.

  5. CCL22 (Montrer CCL22 Protéines)-specific antibodies reveal that engagement of two distinct binding domains on CCL22 (Montrer CCL22 Protéines) is required for CCR4-mediated function.

  6. CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.

  7. Distinctive Treg associated CCR4-CCL22 (Montrer CCL22 Protéines) expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris (Montrer DSG3 Protéines).

  8. Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9 (Montrer MMP9 Protéines).

  9. CCR4 C1014T and CCL22 (Montrer CCL22 Protéines) C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population

  10. Higher percentages of CCR4+ CD4 (Montrer CD4 Protéines) TEM (Montrer CYLD Protéines) cells in acute RSV infection were accompanied with higher percentages of CXCR3 (Montrer CXCR3 Protéines)+ CD8 (Montrer CD8A Protéines) TEM (Montrer CYLD Protéines) cells, whereas the development of long-lived memory CXCR3 (Montrer CXCR3 Protéines)+ CD4 (Montrer CD4 Protéines) and CD8 (Montrer CD8A Protéines) TCM cells seems to be compromised

Profil protéine CCR4

Profil protéine

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Gene names and symbols associated with CCR4

  • C-C motif chemokine receptor 4 (CCR4)
  • CCR4-NOT transcription complex, subunit 6 (Cnot6)
  • chemokine (C-C motif) receptor 4 (Ccr4)
  • C-C motif chemokine receptor 4 (Ccr4)
  • A230103N10Rik Protéine
  • AA407540 Protéine
  • AW456442 Protéine
  • C-C CKR-4 Protéine
  • CC-CKR-4 Protéine
  • CCR4 Protéine
  • CD194 Protéine
  • CHEMR1 Protéine
  • ChemR13 Protéine
  • CKR4 Protéine
  • Cmkbr4 Protéine
  • HGCN:14099 Protéine
  • K5-5 Protéine
  • LESTR Protéine
  • RGD1310783 Protéine
  • Sdf1r Protéine

Protein level used designations for CCR4

chemokine (C-C motif) receptor 4 , C-C chemokine receptor type 4-like , c-C chemokine receptor type 4-like , CCR4-NOT transcription complex subunit 6 , carbon catabolite repressor protein 4 homolog , cytoplasmic deadenylase , C-C CKR-4 , C-C chemokine receptor type 4 , CCR-4 , chemokine (C-C) receptor 4 , CC chemokine receptor 4 , CC-CKR-4 , fusin , leukocyte-expressed seven-transmembrane-domain receptor , C-C chemokine receptor 4

100397096 Callithrix jacchus
100445664 Pongo abelii
100585668 Nomascus leucogenys
104625 Mus musculus
287249 Rattus norvegicus
1233 Homo sapiens
403541 Canis lupus familiaris
408019 Bos taurus
12773 Mus musculus
171054 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour CCR4 Protéines (CCR4)
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