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The protein encoded by CCR4 belongs to the G-protein-coupled receptor family . De plus, nous expédions CCR4 Anticorps (213) et CCR4 Kits (26) et beaucoup plus de produits pour cette protéine.
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A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (Montrer CD8A Protéines)+ effector T cells in mice bearing B16 melanoma.
CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.
CCL22 (Montrer CCL22 Protéines) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells
CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes
results show that the IL-4 (Montrer IL4 Protéines)/CCL22 (Montrer CCL22 Protéines)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
that effective engagement of CCR4 by CCL17 (Montrer CCL17 Protéines) involves two distinct binding domains and interaction with both is required for signaling
NF-kappaB (Montrer NFKB1 Protéines) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role
CCR4-expressing Th2cells play a critical role in the pathogenesis of bronchial asthma by producing Th2 cytokines.
Chemokine (Montrer CCL1 Protéines) receptors CCR3 (Montrer CCR3 Protéines) and CCR4, and the mucosa specific chemokine (Montrer CCL1 Protéines) CCL28 (Montrer ENC1 Protéines) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (Montrer IL6 Protéines) and HGF (Montrer HGF Protéines) and reducing the secretion of TIMP-1 (Montrer TIMP1 Protéines).
The percentage of CXCR3 (Montrer CXCR3 Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TEM (Montrer CYLD Protéines) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (Montrer SELPLG Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TCM cells expressing CCR6 (Montrer CCR6 Protéines)(+) or CCR4(+)CXCR3 (Montrer CXCR3 Protéines)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (Montrer CD8A Protéines)-positive T-cell mediated dermatitis.
CCL22 (Montrer CCL22 Protéines)-specific antibodies reveal that engagement of two distinct binding domains on CCL22 (Montrer CCL22 Protéines) is required for CCR4-mediated function.
CCR4 mutation is an important determinant of the clinical course in ATLL cases, and that NS and FS mutations of CCR4 behave differently with respect to ATLL pathophysiology.
Distinctive Treg associated CCR4-CCL22 (Montrer CCL22 Protéines) expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris (Montrer DSG3 Protéines).
Data show that CCR4 was over-expressed in lymph node-negative human gastric cancer tissues and suggest its involvement in promoting tumor invasion probably, through up-regulation of MMP9 (Montrer MMP9 Protéines).
CCR4 C1014T and CCL22 (Montrer CCL22 Protéines) C16A genetic variations were neither associated with the risk, nor with the progression of colorectal cancer in Iranian population
Higher percentages of CCR4+ CD4 (Montrer CD4 Protéines) TEM (Montrer CYLD Protéines) cells in acute RSV infection were accompanied with higher percentages of CXCR3 (Montrer CXCR3 Protéines)+ CD8 (Montrer CD8A Protéines) TEM (Montrer CYLD Protéines) cells, whereas the development of long-lived memory CXCR3 (Montrer CXCR3 Protéines)+ CD4 (Montrer CD4 Protéines) and CD8 (Montrer CD8A Protéines) TCM cells seems to be compromised
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
chemokine (C-C motif) receptor 4
, C-C chemokine receptor type 4-like
, c-C chemokine receptor type 4-like
, CCR4-NOT transcription complex subunit 6
, carbon catabolite repressor protein 4 homolog
, cytoplasmic deadenylase
, C-C CKR-4
, C-C chemokine receptor type 4
, chemokine (C-C) receptor 4
, CC chemokine receptor 4
, leukocyte-expressed seven-transmembrane-domain receptor
, C-C chemokine receptor 4