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The protein encoded by CCR4 belongs to the G-protein-coupled receptor family .
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the expression of chemokine (Montrer CCL1 Protéines) receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.
This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17 (Montrer CCL17 Protéines), and CCL22 (Montrer CCL22 Protéines) in experimental autoimmune encephalomyelitis pathogenesis. [review]
Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 (Montrer IL6 Protéines) production in ectopic milieu. The high levels of IL-6 (Montrer IL6 Protéines) in the peritoneal cavity stimulate the expression of CCL17 (Montrer CCL17 Protéines) in endometrial stromal cells by activating JNK (Montrer MAPK8 Protéines) signal pathway, and then, CCL17 (Montrer CCL17 Protéines) further induces CCR4 expression on macrophages, which eventually leads to an increase in IL-6 (Montrer IL6 Protéines) production via NF-kappaB (Montrer NFKB1 Protéines) activation.
Investigations showed that the level of CCR4 could be induced by TNF-alpha (Montrer TNF Protéines) dependent of NF-kappaB (Montrer NFKB1 Protéines) activation in CRC (Montrer CALR Protéines) cells. CCR4 might be implicated in TNF-alpha (Montrer TNF Protéines)-regulated cancer cells metastasis.
Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22 (Montrer CCL22 Protéines)-CCR4 signaling axis.
monocyte chemoattractant protein-1 (MCP-1 (Montrer CCL2 Protéines)), an endogenous CCR4-binding ligand, was specifically upregulated in the head and neck squamous cell carcinomamicroenvironment compared to the other four CCR4-binding ligands
Chemokine (Montrer CCL1 Protéines) receptors CCR3 (Montrer CCR3 Protéines) and CCR4, and the mucosa specific chemokine (Montrer CCL1 Protéines) CCL28 (Montrer ENC1 Protéines) have predominant roles in oral wound healing by increasing human gingiva fibroblast proliferation, migration, and the secretion of IL-6 (Montrer IL6 Protéines) and HGF (Montrer HGF Protéines) and reducing the secretion of TIMP-1 (Montrer TIMP1 Protéines).
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
The percentage of CXCR3 (Montrer CXCR3 Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TEM (Montrer CYLD Protéines) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (Montrer SELPLG Protéines)(+) CD4 (Montrer CD4 Protéines)(+) TCM cells expressing CCR6 (Montrer CCR6 Protéines)(+) or CCR4(+)CXCR3 (Montrer CXCR3 Protéines)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Case Report: CCR4+ T-cell depletion by mogamulizumab treatment of adult T-cell leukaemia/lymphoma results in CD8 (Montrer CD8A Protéines)-positive T-cell mediated dermatitis.
data demonstrate a mechanistic or developmental role of CCR4 in the regulation of locomotor and exploratory behaviors
CCR4 is critically involved in regional lymph node dendritic cell-Th17 cell interactions that are necessary for Th17 cell-mediated induction of antitumor CD8 (Montrer CD8A Protéines)+ effector T cells in mice bearing B16 melanoma.
CCR4 is involved in immunosuppression after severe sepsis and suggest that CCR4+ Regulatory T Cells negatively modulate the short and long-term immune responses.
CCL22 (Montrer CCL22 Protéines) was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells
CCR4 is involved in regulating negative selection of polyclonal and T cell receptor (TCR) transgenic thymocytes
results show that the IL-4 (Montrer IL4 Protéines)/CCL22 (Montrer CCL22 Protéines)/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators
These data have uncovered a novel role of core components of the Ccr4-Not complex as regulators of transition from partial to genuine induced pluripotent stem cells.
that effective engagement of CCR4 by CCL17 (Montrer CCL17 Protéines) involves two distinct binding domains and interaction with both is required for signaling
NF-kappaB (Montrer NFKB1 Protéines) signaling pathway was involved in the asthmatic change induced by CKLF1, among which CCR4 might play a crucial role
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
, C-C chemokine receptor type 4
, chemokine (C-C) receptor 4
, chemokine (C-C motif) receptor 4
, C-C chemokine receptor type 4-like
, c-C chemokine receptor type 4-like
, CC-chemokine receptor 4
, leukocyte-expressed seven-transmembrane-domain receptor
, CC chemokine receptor 4
, C-C chemokine receptor 4