Plus produit pour CXCR3 ELISA Kit
CXCR3 Kits ELISA mieux référencés
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Human CXCR3 Kit ELISA pour Sandwich ELISA - ABIN366833 : Zhang, Liu, Su, Shi, Chen: Serum fractalkine and interferon-gamma inducible protein-10 concentrations are early detection markers for acute renal allograft rejection. dans Transplantation proceedings 2014 (PubMed)
Plus Kits ELISA pour CXCR3 partenaires d'interaction
Human Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners
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biased agonists of CXCR3 produce distinct physiological effects, suggesting discrete roles for different endogenous CXCR3 ligands
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CXCR3 protein level significantly increased in osteoarthritis patients.
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Data provide evidence that CXCR3 mediates the function of CXCL4 in colon cancer cells.
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CXCR3 enhanced CXCR4 function in colorectal cancer cells invasion through forming heteromers with CXCR4 on cell surface thus preventing CXCR4 internalization.
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CXCR3 and its chemokines are involved in the recruitment of granulocytes and mononuclear cells, therefore in the maintenance of inflammation in Crohn disease
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In primary biliary cirrhosis (PBC), circulating MIG levels and CXCR3+ cells are related with the progression of the disease; their expression increases significantly in PBC patients with respect to controls
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Expression of CXCL10 was up-regulated in hepatocellular carcinoma (HCC) tissues, expression of CXCR3 was down-regulated in HBV-related HCC tissues
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results suggest that the CXCL10/CXCR3 axis may contribute to the pathogenesis of Behcet's disease
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miR-16-5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3
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The result of this study showed that CXCR3/CXCL10/CXCL11 signaling axis is overexpressed in the small intestinal mucosa of celiac disease patients compared to controls. This finding might explain the specific enrollment of the main cell populations that infiltrate the epithelium
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Study found a respectively increased and decreased expression of CXCR3 splice variants CXCR3A and CXCR3B in colorectal cancer (CRC) tumors. CXCR3A and CXCR3B played disparate roles in regulating progressive characteristics of CRC cells, including the proliferation, invasion, migration, and tumorigenicity. This study suggests that the alternation of CXCR3 splice isoforms is necessary in the metastasis of CRC.
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Study suggests that vitiligo is likely to be initiated in the normal-appearing skin of vitiligo subjects through activation of local innate lymphocyte-induced melanocyte apoptosis and subsequent activation of adaptive and memory immune responses. This apoptosis is mediated by melanocytic CXCR3B, identifying this isoform of CXCR3 chemokine receptor to be critical in melanocyte destruction and initiation of the disease.
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Study shows that the expression level of CXCR3 in T cells was significantly elevated in several neurological diseases. Study reviews evidence that CXCR3 plays a vital role in the pathogenesis of multiple sclerosis, glioma, Alzheimer disease, chronic pain, human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis and bipolar disorder.
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Increased CXCR3 expression is associated with progression of primary open-angle glaucoma.
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IL1B promotes the transendothelial migration of mesenchymal stem cells through CXCR3-CXCL9 axis.
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Study found that vitiligo skin is enriched with CD8 resident memory T cells that express CXCR3. Strikingly, a higher frequency of skin melanocyte-specific CD8 T cells was found within the CXCR3+ subset.
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The populations were identified based on the production of IFN-gamma and/or IL-17 and the coexpression of CXCR3 (X3) and CCR6 (R6).
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High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma.
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Up-regulated CXCR3 is detectable in the amniotic fluid and associated with the presence of placental lesions consistent with maternal anti-fetal rejection so may serve as a potential marker of spontaneous preterm delivery.
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the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.
Mouse (Murine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners
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Our data suggest that the CXCR3 chemokine system is a biomarker for sensitivity to PD-1 blockade and that augmenting the intratumoral function of this chemokine system could improve clinical outcomes.
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Results suggest that CXCR3 confers early protection against S. typhimurium infection which is crucial in preventing bacterial dissemination to the spleen and liver of mice. Both the early recruitment of CXCR3-expressing neutrophils and CXCR3-mediated IFN-gamma secretion are instrumental in an effective immune response against gram-negative S. typhimurium.
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Salmonella enterica (Se) infection stimulates robust expansion of chemokine (C-X-C motif) receptor 3 (CXCR3+) Th1 cells.
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Further analysis revealed that IRF1 deficiency suppress interferon-gamma production and delayed CD8+ T cell proliferation. CXCR3 expression was found to be decreased in pathogenic CD8+ T cells, which limited their migration to the brain
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CXCR3-deficient mesenchymal stem cells did not ameliorate lupus symptoms in MRL. Fas(lpr) mice in comparison with wild-type mesenchymal stem cells. The data suggest that upregulation of CXCR3 in mesenchymal stem cells will be a good strategy to increase their infiltration into the kidney in mice, which will improve therapeutic outcomes in systemic lupus erythematosus (SLE).
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The data illustrate the paradoxical pro-tumor role for CXCR3 in lung immunobiology wherein the CXCR3 axis drives both the anti-tumor effector cell chemoattraction and pro-tumor infiltration of the lungs and suggests a potential therapeutic target for lung-tropic metastasizing cancers.
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the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection.
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The data of this study suggested that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.
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Study provided the evidence that CXCL10/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.
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The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.
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results show an important role for CXCR3 and CXCL10 in the tissue distribution of preimmune memory phenotype CD8 T- cells
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Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8(+) T cells.
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Data suggest that the CXCL9-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
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ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10-CXCR3 axis at multiple levels.
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study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 and MIG
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Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.
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this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10/CXCR3 axis
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These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
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Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8+NKG2D+ T cells into the skin
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Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha which contributes to neuropathic pain.
Cow (Bovine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners
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Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
Zebrafish Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners
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The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system.
CXCR3 profil antigène
Antigen Summary
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
Gene names and symbols associated with CXCR3
- C-X-C motif chemokine receptor 3 (CXCR3) anticorps
- chemokine (C-X-C motif) receptor 3 (Cxcr3) anticorps
- chemokine (C-X-C motif) receptor 3 (cxcr3) anticorps
- C-X-C motif chemokine receptor 3 (Cxcr3) anticorps
- chemokine (C-X-C motif) receptor 3, tandem duplicate 1 (cxcr3.1) anticorps
- CD182 anticorps
- Cd183 anticorps
- CKR-L2 anticorps
- Cmkar3 anticorps
- CXC-R3 anticorps
- CXCR-3 anticorps
- cxcr3 anticorps
- Gpr9 anticorps
- IP10-R anticorps
- Mig-R anticorps
- MigR anticorps
- sb:eu378 anticorps
Protein level used designations for CXCR3
C-X-C chemokine receptor type 3 , CXC-R3 , CXCR-3 , G protein-coupled receptor 9 , IP-10 receptor , IP10 receptor , Mig receptor , chemokine (C-X-C) receptor 3 , interferon-inducible protein 10 receptor , chemokine (C-X-C motif) receptor 3 , CXC chemokine receptor 3 , Interferon-inducible protein 10 receptor , CXCR3ab , chemokine (C-X-C motif) receptor 3.1 , dr-chr16-CXCR3-41.8%-EK27498 , dr-chr16-CXCR3-41.8-EK27498
GENE ID | SPECIES |
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2833 | Homo sapiens |
12766 | Mus musculus |
465704 | Pan troglodytes |
491952 | Canis lupus familiaris |
496477 | Xenopus (Silurana) tropicalis |
497018 | Bos taurus |
699438 | Macaca mulatta |
84475 | Rattus norvegicus |
100860874 | Capra hircus |
654692 | Danio rerio |
- Chemokine (C-X-C Motif) Receptor 2 Kits ELISA
- Chemokine (C-X-C Motif) Receptor 1 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 5 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 3 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 2 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 17 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 16 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 15 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 14 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 13 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 12 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 11 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 10 Kits ELISA
- Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) Kits ELISA
- Chemokine (C-C Motif) Receptor-Like 2 Kits ELISA
- Chemokine (C-C Motif) Receptor-Like 1 Kits ELISA
- Chemokine (C-C Motif) Receptor 8 Kits ELISA
- Chemokine (C-C Motif) Receptor 7 Kits ELISA
- Chemokine (C-C Motif) Receptor 6 Kits ELISA
- Chemokine (C-C Motif) Receptor 5 Kits ELISA
- Chemokine (C-X-C Motif) Receptor 4 Kits ELISA
- Chemokine (C-X-C Motif) Receptor 5 Kits ELISA
- Chemokine (C-X-C Motif) Receptor 6 Kits ELISA
- Chemokine (C-X-C Motif) Receptor 7 Kits ELISA
- Chemokine (C-X3-C Motif) Ligand 1 Kits ELISA
- Chemokine (C-X3-C Motif) Receptor 1 Kits ELISA
- Chemokine Binding Protein 2 Kits ELISA
- Chemokine-Like Factor Kits ELISA
- Chemokine-Like Receptor 1 Kits ELISA
- Chibby Homolog 1 (Drosophila) Kits ELISA
- Chitinase 3-Like 1 (Cartilage Glycoprotein-39) Kits ELISA
- Chitinase 3-Like 2 Kits ELISA
- Chitinase 3-Like 3 Kits ELISA
- Chitinase 3-Like 4 Kits ELISA
- Chitinase Domain Containing 1 Kits ELISA
- Chitinase, Acidic Kits ELISA
- Chitobiase, Di-N-Acetyl Kits ELISA
- Chitotriosidase Kits ELISA
- Chloride Channel 1, Skeletal Muscle Kits ELISA
- Chloride Channel 3 Kits ELISA