Chemokine (C-X-C Motif) Receptor 3 (CXCR3) Kits ELISA

Human Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

1. results suggest that the CXCL10/CXCR3 axis may contribute to the pathogenesis of Behcet's disease

2. miR-16-5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3

3. The result of this study showed that CXCR3/CXCL10/CXCL11 signaling axis is overexpressed in the small intestinal mucosa of celiac disease patients compared to controls. This finding might explain the specific enrollment of the main cell populations that infiltrate the epithelium

4. Study found a respectively increased and decreased expression of CXCR3 splice variants CXCR3A and CXCR3B in colorectal cancer (CRC) tumors. CXCR3A and CXCR3B played disparate roles in regulating progressive characteristics of CRC cells, including the proliferation, invasion, migration, and tumorigenicity. This study suggests that the alternation of CXCR3 splice isoforms is necessary in the metastasis of CRC.

5. Study suggests that vitiligo is likely to be initiated in the normal-appearing skin of vitiligo subjects through activation of local innate lymphocyte-induced melanocyte apoptosis and subsequent activation of adaptive and memory immune responses. This apoptosis is mediated by melanocytic CXCR3B, identifying this isoform of CXCR3 chemokine receptor to be critical in melanocyte destruction and initiation of the disease.

6. Study shows that the expression level of CXCR3 in T cells was significantly elevated in several neurological diseases. Study reviews evidence that CXCR3 plays a vital role in the pathogenesis of multiple sclerosis, glioma, Alzheimer disease, chronic pain, human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis and bipolar disorder.

7. Increased CXCR3 expression is associated with progression of primary open-angle glaucoma.

8. IL1B promotes the transendothelial migration of mesenchymal stem cells through CXCR3-CXCL9 axis.

9. Study found that vitiligo skin is enriched with CD8 resident memory T cells that express CXCR3. Strikingly, a higher frequency of skin melanocyte-specific CD8 T cells was found within the CXCR3+ subset.

10. The populations were identified based on the production of IFN-gamma and/or IL-17 and the coexpression of CXCR3 (X3) and CCR6 (R6).

11. High CXCR3 expression is associated with invasion and metastasis in tongue squamous cell carcinoma.

12. Up-regulated CXCR3 is detectable in the amniotic fluid and associated with the presence of placental lesions consistent with maternal anti-fetal rejection so may serve as a potential marker of spontaneous preterm delivery.

13. the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis, was examined.

14. Results suggest that infiltration of chemokine (C-X-C motif) receptor 3 (CXCR3)-positive plasma cells is a characteristic feature of Hunner type interstitial cystitis (HIC).

15. Results of this study indicate that CXCR3 overexpression in GC is associated with increased DC and TIL infiltration and improved OS.

16. Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNgamma and IL-17 remained unchanged when co-cultured with chrysotile.

17. In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.

18. Alternatively spliced variant of CXCR3 mediates the metastasis of liver cancer.

19. The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.

20. approach has been able to describe the structural events which dynamically characterize the molecular mechanisms involved in the binding of CXCR3 to CXCL11 and the critical role exerted by its N-terminal region in "hunting" and capturing the ligand.

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

1. Results suggest that CXCR3 confers early protection against S. typhimurium infection which is crucial in preventing bacterial dissemination to the spleen and liver of mice. Both the early recruitment of CXCR3-expressing neutrophils and CXCR3-mediated IFN-gamma secretion are instrumental in an effective immune response against gram-negative S. typhimurium.

2. Salmonella enterica (Se) infection stimulates robust expansion of chemokine (C-X-C motif) receptor 3 (CXCR3+) Th1 cells.

3. Further analysis revealed that IRF1 deficiency suppress interferon-gamma production and delayed CD8+ T cell proliferation. CXCR3 expression was found to be decreased in pathogenic CD8+ T cells, which limited their migration to the brain

4. CXCR3-deficient mesenchymal stem cells did not ameliorate lupus symptoms in MRL. Fas(lpr) mice in comparison with wild-type mesenchymal stem cells. The data suggest that upregulation of CXCR3 in mesenchymal stem cells will be a good strategy to increase their infiltration into the kidney in mice, which will improve therapeutic outcomes in systemic lupus erythematosus (SLE).

5. The data illustrate the paradoxical pro-tumor role for CXCR3 in lung immunobiology wherein the CXCR3 axis drives both the anti-tumor effector cell chemoattraction and pro-tumor infiltration of the lungs and suggests a potential therapeutic target for lung-tropic metastasizing cancers.

6. the data suggest that CXCR3 and the integrin alpha4 mediate T cell recruitment to uninfected salivary glands but that redundant mechanisms mediate T cell recruitment after Murine Cytomegalovirus infection.

7. The data of this study suggested that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.

8. Study provided the evidence that CXCL10/CXCR3 signaling in periaqueductal gray is involved in the development of morphine analgesic tolerance via neuron-microglia interaction.

9. The results demonstrate that the recruitment of peripheral immune cells into the CNS, induction of neuroinflammation, and consecutive weight loss during herpes encephalitis is modulated by CXCR3 signaling.

10. results show an important role for CXCR3 and CXCL10 in the tissue distribution of preimmune memory phenotype CD8 T- cells

11. Our data suggests that the altered gene profiles induced by CXCR3 deficiency promotes autoimmune cholangitis through pathogenic CD8(+) T cells.

12. Data suggest that the CXCL9-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.

13. ATF3-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10-CXCR3 axis at multiple levels.

14. study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 and MIG

15. Antigen targeting to DEC-205 on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 cells in vivo. This downregulation interferes with the migration of Th1 cells into the gut and protects mice against severe acute and relapsing intestinal inflammation.

16. this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10/CXCR3 axis

17. These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.

18. Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8+NKG2D+ T cells into the skin

19. Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha which contributes to neuropathic pain.

20. These findings demonstrate that the CXCL10/CXCR3 chemokine pathway is critical in shaping CD8(+) T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease.

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

1. Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression

Zebrafish Chemokine (C-X-C Motif) Receptor 3 (CXCR3) interaction partners

1. The demonstration of a conserved CXCR3-CXCL11 signaling axis in zebrafish extends the translational applicability of this model for studying diseases involving the innate immune system.