Chitinase 3-Like 2 (CHI3L2) Kits ELISA

Human Chitinase 3-Like 2 (CHI3L2) interaction partners

1. Results find that expression of CHI3L2 in tumor cells of conventional small renal cell carcinomas defines a group of patients at high risk for postoperative progression.

2. In patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.

3. This study suggests that CHI3L1 and CHI3L2 are associated with the progression of neurodegeneration in motor cortex and spinal cord of Amyotrophic Lateral Sclerosis patients.

4. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex.

5. This review comprehensively analyzes recent data about expression pattern, and involvement of human YKL-40, YKL-39 and SI-CLP in cancer. [review]

6. cerebrospinal fluid CHI3L1 and CHI3L2 and serum CHI3L1 might help to define multiple sclerosis disease stage

7. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy.

8. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis.

9. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis.

10. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation.

11. human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) is upregulated in osteoarthritic cartilage