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The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. De plus, nous expédions CHRNA5 Protéines (6) et CHRNA5 Kits (5) et beaucoup plus de produits pour cette protéine.
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Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls.
The rs13180 (IREB2 (Montrer IREB2 Anticorps)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (Montrer CHRNA3 Anticorps)) were significantly associated with Chronic obstructive pulmonary disease (COPD (Montrer ARCN1 Anticorps)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (Montrer ARCN1 Anticorps) in our population (Padj =0.0005, OR=0.61).
Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer
our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
The minor allele increased the risk of COPD (Montrer ARCN1 Anticorps) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (Montrer ARCN1 Anticorps) patients and with the number of pack-years among the male smokers.
The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (Montrer ARCN1 Anticorps)) and rs8040868 as a risk variant for the development of COPD (Montrer ARCN1 Anticorps) in the Swedish population.
The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
Polymorphisms in the CHRNA5 and NRXN1 (Montrer NRXN1 Anticorps) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.
RP11 (Montrer PRPF31 Anticorps)-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.
We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).
The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.
Genetic deletion of alpha5 nAChR (Montrer CHRNA4 Anticorps) subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors.
Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (Montrer CHRNA4 Anticorps) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.
These results highlight the involvement of the alpha5 nAChR (Montrer CHRNA4 Anticorps) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.
Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice
Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (Montrer CHRNA4 Anticorps) subunit expression during important periods of lung morphogenesis by FoxA2 (Montrer FOXA2 Anticorps).
increased nicotine intake in mice with a null mutation in Chrna5
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
neuronal acetylcholine receptor subunit alpha-5
, cholinergic receptor, nicotinic, alpha polypeptide 5
, Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5
, acetylcholine receptor, nicotinic, alpha 5 (neuronal)
, neuronal nicotinic acetylcholine receptor, alpha5 subunit
, acetylcholine receptor alpha 5
, cholinergic receptor neuronal nicotinic alpha protein 5
, nicotinic acetylcholine receptor alpha5 subunit