anti-Chromodomain Helicase DNA Binding Protein 4 (CHD4) Anticorps

The product of CHD4 belongs to the SNF2/RAD54 helicase family. De plus, nous expédions CHD4 Kits (7) et CHD4 Protéines (6) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CHD4 1108 Q14839
CHD4 117535  
CHD4 107932 Q6PDQ2
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Top anti-CHD4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 75 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-CHD4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: OVCAR-3 cell lysate There is BioGPS gene expression data showing that CHD4 is expressed in OVCAR3 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of CHD4 staining in HEK293 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Immunohistochemical analysis of CHD4 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using CHD4 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using CHD4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ICC, IF, IP, WB IP Image Immunoprecipitation of CHD4 protein from 293T whole cell extracts using 5 μg of CHD4 antibody, Western blot analysis was performed using CHD4 antibody, EasyBlot anti-Rabbit IgG  was used as a secondary reagent. WB Image Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: K562 5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Détails
Roussette (Chauve-souris) Lapin Inconjugué IHC, IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CHD4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other form ... 100 μL 11 to 14 Days
$727.83
Détails
Humain Souris Inconjugué IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to CHD4 on formalin-fixed paraffin-embedded human transitional cell carcinoma. [antibody concentration 3 ug/ml] CHD4 monoclonal antibody (M01), clone 4H4 Western Blot analysis of CHD4 expression in Hela S3 NE . 100 μg 11 to 12 Days
$364.00
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CHD4 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11 to 14 Days
$742.50
Détails
Humain Lapin Inconjugué IF, IHC, WB 100 μL 11 to 13 Days
$476.15
Détails
Humain Lapin Inconjugué ICC, IF, IHC, WB Mi-2 beta antibody tested by immunofluorescence. Top left: HeLa cells stained with Mi-2 beta antibody (1:1,000). Top right: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Same cells stained with DAPI. Bottom right: Merge of all 3 images. Mi-2 beta antibody tested by Western blot. Whole-cell extract of mouse splenocytes stained with Mi-2 beta antibody (1:1,1000). 100 μL 1 to 2 Days
$507.50
Détails
Humain Souris Inconjugué ELISA, WB   100 μL Disponible
$363.46
Détails

anti-CHD4 Anticorps mieux référencés

  1. Human Polyclonal CHD4 Primary Antibody pour ICC, IF - ABIN6579173 : Curtis, Griffin: The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. dans Molecular and cellular biology 2012 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal CHD4 Primary Antibody pour IHC (p), ELISA - ABIN560357 : Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. dans The Journal of biological chemistry 2014 (PubMed)

  3. Human Polyclonal CHD4 Primary Antibody pour IP, WB - ABIN252857 : Shakya, Kang, Chumley, Williams, Tantin: Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. dans The Journal of biological chemistry 2011 (PubMed)

  4. Human Polyclonal CHD4 Primary Antibody pour IP, WB - ABIN252859 : Gu, Hu, Ebrahem, Crabb, Mahfouz, Radivoyevitch, Crabb, Saunthararajah: Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. dans The Journal of biological chemistry 2014 (PubMed)

  5. Human Polyclonal CHD4 Primary Antibody pour IP, PLA - ABIN252858 : Ma, Lin, Bartolomei, Schultz: Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. dans Biology of reproduction 2010 (PubMed)

  6. Fruit Fly (Drosophila melanogaster) Monoclonal CHD4 Primary Antibody pour IP, WB - ABIN2668526 : Murawska, Kunert, van Vugt, Längst, Kremmer, Logie, Brehm: dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. dans Molecular and cellular biology 2008 (PubMed)

  7. Human Monoclonal CHD4 Primary Antibody pour ChIP, CyTOF - ABIN4297878 : Yen, Sharma, Cols, Lau, Chaudhry, Chowdhury, Yewdell, Vaidyanathan, Sun, Coffre, Pucella, Chen, Jasin, Sun, Rudensky, Koralov, Chaudhuri: Distinct Requirements of CHD4 during B Cell Development and Antibody Response. dans Cell reports 2019 (PubMed)

Plus d’anticorps contre CHD4 partenaires d’interaction

Human Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. the results indicated that different location of CHD4 staining is a potential biomarker to differentiate cellular schwannoma from malignant peripheral sheath tumor.

  2. CHD4 is essential for maintenance of childhood AML and the LICs that are responsible for the emergence and development of the disease. Our data indicate that the importance of CHD4 in childhood AML may be mediated in part by promoting the expression of the MYC oncogene and its target genes.

  3. Alterations of EZH2, KMT2C, and CHD4 at genetic level or protein level could perturb epigenetic program, leading to malignant transformation in glioma.

  4. that CHD4 is not only a potential prognostic biomarker for triple-negative breast cancer (TNBC) patient survival, but is also a powerful candidate in the development of new anti-cancer agents in TNBC

  5. the N-terminal part of CHD4 interacts with an unstructured A-rich region in promoter and pre-rRNA antisense "), a long noncoding RNA that is transcribed in an orientation antisense to pre-rRNA

  6. RNA interference identifies CHD4 as an essential gene in regulating breast cancer growth.

  7. Data suggest TCF19 interacts with histone 3 lysine 4 trimethylation through its plant homeodomain finger; TCF19 expression appears to regulate gluconeogenesis in hepatocytes; TCF19 interacts with CHD4 causing NuRD complex recruitment to gene promoters of enzymes involved in gluconeogenesis. (TCF19 = transcription factor 19; CHD4 = chromodomain helicase DNA binding protein 4; NuRD = nucleosome-remodeling-deacetylase)

  8. CHD3 and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes.

  9. The findings identify that CHD4 deficiency preferentially impairs cell survival via increasing the level of p21.

  10. Mutation in CHD4 gene is associated with congenital heart defects.

  11. this work identifies CHD4 as an epigenetic coregulator of PAX3-FOXO1 activity, providing rational evidence for CHD4 as a potential therapeutic target in alveolar rhabdomyosarcoma.

  12. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation. At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing.

  13. this study identifies the Chd4-Tbx3 axis in controlling ESC fate and a role of H2A.Z in maintaining the stability of Chd4 proteins.

  14. report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification

  15. complex lacking CHD4 that has HDAC activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.

  16. CHD4 plays a pivotal role in chemoresistance and the maintenance of stemness in liver cancer stem cells and is therefore a good target for the eradication of hepatocellular carcinoma.

  17. Acetyltransferase p300 collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair

  18. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD domain and MBD2 C-terminus.

  19. these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.

  20. CHD4 depletion modulates expression of acute myeloid leukemia cell genes that regulate tumor formation in vivo and colony formation in vitro.

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. It validates a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly.

  2. Mi-2beta promotes pre-B-cell differentiation by providing repression capabilities to distinct lineage-specific transcription factor-based regulatory networks.

  3. findings reveal that the CHD4/NuRD complex regulates neural differentiation of ESCs by down-regulating p53.

  4. results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues

  5. Direct CHD4-mediated repression of skeletal and smooth muscle myofibril isoforms is required for normal cardiac sarcomere formation, function, and embryonic survival early in gestation. Unique CHD4 binding sites are found in smooth muscle myosin heavy chain, fast skeletal alpha-actin, and the fast skeletal troponin complex genes.

  6. RNA interference identifies CHD4 as an essential gene in regulating breast cancer growth.

  7. Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system.

  8. This secreted effector, toxoplasma inhibitor of STAT1-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1-dependent promoters, resulting in altered chromatin and blocked transcription.

  9. this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state

  10. preservation of the identity of the two striated muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD.

  11. complex lacking CHD4 that has HDAC activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.

  12. CHD4 depletion modulates expression of acute myeloid leukemia cell genes that regulate tumor formation in vivo and colony formation in vitro.

  13. CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.

  14. Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells

  15. Chd4, interacting with Hdac1/2, cooperates with its related proteins Kap1 and Cbx1 to bind at -207/-148 of the Sox9 promoter.

  16. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.

  17. The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 required specifically for Polycomb group (PcG)-mediated suppression of the key astrogenic marker gene GFAP.

  18. Gata3/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.

  19. In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis

  20. Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment.

Xenopus laevis Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.

CHD4 profil antigène

Profil protéine

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Gene names and symbols associated with CHD4

  • chromodomain helicase DNA binding protein 4 (CHD4) anticorps
  • chromodomain helicase DNA binding protein 4a (chd4a) anticorps
  • chromodomain helicase DNA binding protein 4b (chd4b) anticorps
  • chromodomain helicase DNA binding protein 4 (chd4) anticorps
  • chromodomain helicase DNA binding protein 4 (Chd4) anticorps
  • chromodomain helicase DNA binding protein 4 L homeolog (chd4.L) anticorps
  • 9530019N15Rik anticorps
  • AA617397 anticorps
  • b230399n07 anticorps
  • BC005710 anticorps
  • CHD4 anticorps
  • D6Ertd380e anticorps
  • im:7143343 anticorps
  • MGC145363 anticorps
  • Mi-2 anticorps
  • Mi-2b anticorps
  • Mi-2beta anticorps
  • Mi2-BETA anticorps
  • mKIAA4075 anticorps
  • si:ch211-51m24.3 anticorps
  • si:ch211-57k11.10 anticorps
  • wu:fb44b12 anticorps
  • wu:fd12d03 anticorps

Protein level used designations for CHD4

chromodomain helicase DNA binding protein 4 , chromodomain-helicase-DNA-binding protein 4 , ATP-dependent helicase CHD4 , CHD-4 , Mi-2 autoantigen 218 kDa protein , Mi-2 autoantigen , Mi-2 beta

GENE ID SPECIES
418278 Gallus gallus
451788 Pan troglodytes
558344 Danio rerio
560622 Danio rerio
100059817 Equus caballus
100124711 Xenopus (Silurana) tropicalis
100515610 Sus scrofa
100539798 Meleagris gallopavo
100566510 Anolis carolinensis
1108 Homo sapiens
117535 Rattus norvegicus
107932 Mus musculus
380196 Xenopus laevis
477714 Canis lupus familiaris
506402 Bos taurus
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