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Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination.
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The relative scarcity of oligodendrocyte lineage cells expressing MYRF in demyelinated MS lesions demonstrates, for the first time, that chronic lesions lack oligodendrocytes that express this necessary transcription factor for remyelination and supports the notion that a failure to fully differentiate underlies remyelination failure.
molecular mechanisms underlying the homo-trimerization of Myrf N-terminal fragments and the homo-trimeric DNA binding of Myrf N-terminal fragments
A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.
Purification, crystallization and X-ray analysis of DNA-binding domain of MRF has been reported.
mutant huntingtin (Montrer HTT Anticorps) binds abnormally to MYRF and affects its transcription activity
Here we identify Myrf as an oligodendrocyte-specific target of Sox10 (Montrer SOX10 Anticorps) and map a Sox10 (Montrer SOX10 Anticorps) responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene
Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin.
NPC1 (Montrer NPC1 Anticorps) protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1 (Montrer NPC1 Anticorps)-mutant mice
Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination.
Transcription regulator required for expression of CNS myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and central nervous system (CNS) myelination. Probably acts as a transcription factor that directly binds DNA and activates expression of CNS myelin genes.
myelin gene regulatory factor