Chromosome 12 Open Reading Frame 52 Protéines (C12orf52)

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. De plus, nous expédions Chromosome 12 Open Reading Frame 52 Anticorps (28) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
C12orf52 84934 Q96K30
Souris C12orf52 C12orf52 100764 Q9D1H0
C12orf52 288683 Q2KJ10
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Top Chromosome 12 Open Reading Frame 52 Protéines sur anticorps-enligne.fr

Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Levure Xenopus laevis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,607.00
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,665.67
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Levure REACT_Panda His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,700.50
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Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,700.50
Détails

C12orf52 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human

Rat (Rattus)

Plus protéines pour Chromosome 12 Open Reading Frame 52 (C12orf52) partenaires d'interaction

Xenopus laevis Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52) as a novel rbpj/CBF-1 (Montrer RBPJ Protéines)-interacting protein.

Human Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA (Montrer ZNF331 Protéines) binds RBP-J (Montrer RBPJ Protéines) similarly to the RAM (Montrer RAB27A Protéines) (RBP-J (Montrer RBPJ Protéines)-associated molecule) domain of Notch (Montrer NOTCH1 Protéines), our biochemical and cellular assays suggest that RITA (Montrer ZNF331 Protéines) interacts with additional regions in RBP-J (Montrer RBPJ Protéines).

  2. RITA (Montrer ZNF331 Protéines) overexpression increased expression of p53 (Montrer TP53 Protéines) and Fbxw7 (Montrer FBXW7 Protéines) and downregulated expression of cyclin D1 (Montrer CCND1 Protéines), cyclin E (Montrer CCNE1 Protéines), CDK2 (Montrer CDK2 Protéines), Hes-1 (Montrer HES1 Protéines) and NF-kappaB (Montrer NFKB1 Protéines) p65 (Montrer GORASP1 Protéines). These changes led to growth inhibition and induced G0/G1 cell cycle arrest and apoptosis in SMMC7721 and HepG2 cells.

  3. human RITA (Montrer ZNF331 Protéines), binding to Drosophila Su(H (Montrer RBPJ Protéines)) and tubulin (Montrer TUBB Protéines), cannot influence the Notch (Montrer NOTCH1 Protéines) signalling pathway in the fly

  4. RITA (Montrer ZNF331 Protéines) might suppress tumor growth and induce apoptosis in hepatocellular carcinoma.

Mouse (Murine) Chromosome 12 Open Reading Frame 52 (C12orf52) interaction partners

  1. structural and biophysical studies demonstrate that RITA binds RBP-J (Montrer RBPJ Protéines) similarly to the RAM (Montrer FAM103A1 Protéines) (RBP-J (Montrer RBPJ Protéines)-associated molecule) domain of Notch (Montrer NOTCH1 Protéines), our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J (Montrer RBPJ Protéines).

Profil protéine Chromosome 12 Open Reading Frame 52 (C12orf52)

Profil protéine

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).

Gene names and symbols associated with C12orf52

  • RBPJ interacting and tubulin associated 1 (RITA1)
  • RBPJ interacting and tubulin associated 1 L homeolog (rita1.L)
  • RBPJ interacting and tubulin associated 1 (Rita1)
  • AI853657 Protéine
  • C12orf52 Protéine
  • C86297 Protéine
  • Rita Protéine

Protein level used designations for C12orf52

chromosome 12 open reading frame 52 , RBP-J interacting and tubulin associated , RBPJ-interacting and tubulin-associated protein

GENE ID SPECIES
712837 Macaca mulatta
100381047 Xenopus laevis
84934 Homo sapiens
533158 Bos taurus
100764 Mus musculus
288683 Rattus norvegicus
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