Chromosome 19 Open Reading Frame 40 Protéines (C19ORF40)

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].. De plus, nous expédions Chromosome 19 Open Reading Frame 40 Anticorps (10) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
C19ORF40 91442 Q9BTP7
C19ORF40 101831 Q8BHL6
C19ORF40 510793 Q2KHY5
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Top Chromosome 19 Open Reading Frame 40 Protéines sur anticorps-enligne.fr

Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,531.83
Détails

C19ORF40 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Cow (Bovine)

Plus protéines pour Chromosome 19 Open Reading Frame 40 (C19ORF40) partenaires d'interaction

Human Chromosome 19 Open Reading Frame 40 (C19ORF40) interaction partners

  1. This is the first report of an FAAP24 loss of function mutation found in human patients with EBV-associated lymphoproliferation (Montrer FAS Protéines).

  2. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.

  3. Crystal structure of the FANCM-FAAP24 complex.

  4. Results show that the first HhH (Montrer SLC25A15 Protéines) motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin.

  5. FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.

  6. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.

  7. FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA.

  8. FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity

  9. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM.

  10. DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia (Montrer PALB2 Protéines).

Profil protéine Chromosome 19 Open Reading Frame 40 (C19ORF40)

Profil protéine

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007

Gene names and symbols associated with C19ORF40

  • Fanconi anemia core complex associated protein 24 (FAAP24)
  • Fanconi anemia core complex associated protein 24 (Faap24)
  • AW124591 Protéine
  • AW538696 Protéine
  • Faap24 Protéine

Protein level used designations for C19ORF40

Fanconi anemia-associated protein of 24 kDa , Fanconi anemia-associated protein, 24 kDa

GENE ID SPECIES
510793 Bos taurus
91442 Homo sapiens
101831 Mus musculus
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