anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa Anticorps

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain.

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Type
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Antigène
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Réactivité
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  • 8
  • 8
  • 5
  • 3
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  • 20
  • 13
  • 6
  • 3
Hote
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  • 5
Clonalité
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  • 2
Clone
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Epitope
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  • 9
  • 8
  • 8
  • 7
Conjugué
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  • 4
  • 3
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Isotype
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100 μL
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Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) profil antigène

Profil protéine

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene names and symbols associated with CPSF4

  • cleavage and polyadenylation specific factor 4 (CPSF4) anticorps
  • cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) anticorps
  • cleavage and polyadenylation specific factor 4 (LOC733099) anticorps
  • cleavage and polyadenylation specific factor 4 (LOC100360200) anticorps
  • cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S) anticorps
  • cleavage and polyadenylation specific factor 4 (cpsf4) anticorps
  • cleavage and polyadenylation specific factor 4 (Cpsf4) anticorps
  • 30kDa anticorps
  • C79664 anticorps
  • CPSF30 anticorps
  • NAR anticorps
  • NEB1 anticorps

Protein level used designations for CPSF4

no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD

GENE ID SPECIES
463572 Pan troglodytes
660072 Tribolium castaneum
733099 Bombyx mori
100360200 Rattus norvegicus
444766 Xenopus laevis
493312 Xenopus (Silurana) tropicalis
708119 Macaca mulatta
100224162 Taeniopygia guttata
54188 Mus musculus
304277 Rattus norvegicus
10898 Homo sapiens
416494 Gallus gallus
489859 Canis lupus familiaris
280875 Bos taurus