anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) Anticorps

The protein encoded by CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. De plus, nous expédions CPSF6 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CPSF6 432508 Q6NVF9
CPSF6 11052 Q16630
CPSF6 299811  
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Top anti-CPSF6 Anticorps sur anticorps-enligne.fr

Showing 10 out of 57 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IF, IHC, WB WB Suggested Anti-CPSF6 Antibody Titration: 0.3125ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate CPSF6 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit Anti-CPSF6 Antibody Paraffin Embedded Tissue: Human Muscle Cellular Data: Skeletal muscle cells Antibody Concentration: 16.0 ug/ml Magnification: 400X 100 μL 2 to 3 Days
$229.00
Détails
Poulet Lapin Inconjugué IHC, IHC (p), WB 100 μL 11 to 14 Days
$493.17
Détails
Humain Souris Inconjugué IF, ELISA, WB CPSF6 monoclonal antibody (M10), clone 3F11 Western Blot analysis of CPSF6 expression in HeLa . Immunofluorescence of monoclonal antibody to CPSF6 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of CPSF6 using HT29 whole cell lysates 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, WB 100 μg 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB Western Blot at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis in Hela cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Détails
Humain Lapin Inconjugué WB Western blot analysis of extracts of various cell lines, using CPSF6 antibody. Western blot analysis of extracts of various cell lines, using CPSF6 antibody (ABIN4903368) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s. 100 μL 11 to 13 Days
$366.77
Détails
Chien Lapin Inconjugué IHC, ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Lapin Inconjugué IHC, WB CPSF6 antibody was used for immunohistochemistry at a concentration of 16.0 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X CPSF6 antibody used at 0.3125 ug/ml to detect target protein. 100 μg 9 to 11 Days
$369.29
Détails
Humain Lapin Inconjugué IF, IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human muscle with CPSF6 polyclonal antibody . Immunofluorescent staining of SK-OV-3 cell with CPSF6 polyclonal antibody under 4 ug/mL working concentration. 100 μL 11 to 12 Days
$356.00
Détails

anti-CPSF6 Anticorps mieux référencés

  1. Human Polyclonal CPSF6 Primary Antibody pour ICC, IF - ABIN253249 : Fricke, Valle-Casuso, White, Brandariz-Nuñez, Bosche, Reszka, Gorelick, Diaz-Griffero: The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6. dans Retrovirology 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal CPSF6 Primary Antibody pour IF, ELISA - ABIN524445 : Kim, Yamamoto, Chen, Aida, Wada, Handa, Yamaguchi: Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. dans Genes to cells : devoted to molecular & cellular mechanisms 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal CPSF6 Primary Antibody pour ICC, IF - ABIN4300333 : De Iaco, Santoni, Vannier, Guipponi, Antonarakis, Luban: TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. dans Retrovirology 2013 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre CPSF6 partenaires d’interaction

Mouse (Murine) Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. Here we report that the CFIm subunits NUDT21/CPSF5 and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells.

Human Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. A novel CPSF6-RARG fusion transcript in acute myeloid leukemia.

  2. CPSF6-capsid interactions allow the virus to bypass peripheral heterochromatin and penetrate the nuclear structure for integration.

  3. The authors demonstrate that CFIm functions as an enhancer-dependent activator of mRNA 3' processing. CFIm regulates global alternative polyadenylation by specifically binding and activating enhancer-containing poly(A) sites.

  4. High CPSF6 expression is associated with HIV infections.

  5. we found CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes.

  6. Studies suggest that binding of cleavage factor Im (CFIm) may be one of the earliest steps in promoting formation of an active cleavage complex.

  7. CPSF6 binding to its docking site in HIV-1 capsid leads to the recruitment of CFIm tetramer, suggesting that CFIm mediates CPSF6 function(s) in integration site targeting.

  8. integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 interaction drives integration into gene bodies.

  9. NUP153 and CPSF6 have overlapping binding sites, but each makes unique capsid monomers (CA) interactions. Multiple ligands share an overlapping interface in HIV-1 capsid that is lost upon viral disassembly.

  10. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

  11. study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo

  12. CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA).

  13. These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6.

  14. Loss-of-function of CFIm68 and CFIm25 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells.

  15. TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6.

  16. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly.

  17. Knockdown of CF I(m)68 induced a systematic use of proximal polyadenylation sites, indicating that changes in relative abundance of a single 3' end processing factor can modulate the length of 3' untranslated regions across the transcriptome.

  18. A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid.

  19. The study reports the crystal structure of human cleavage factor I(m), comprising cleavage factor I(m)25 and the RNA recognition motif domain of cleavage factor I(m)68 kDa (CF I(m)68RRM).

  20. Crystal structure of CFIm25-CFIm68 RRM heterotetramer illustrated that CFIm25 homodimer is clamped by two CFIm68 monomers on each side of the dimer interface

CPSF6 profil antigène

Profil protéine

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Gene names and symbols associated with CPSF6

  • cleavage and polyadenylation specific factor 6 (CPSF6) anticorps
  • cleavage and polyadenylation specific factor 6 S homeolog (cpsf6.S) anticorps
  • cleavage and polyadenylation specific factor 6 (cpsf6) anticorps
  • cleavage and polyadenylation specific factor 6 (Cpsf6) anticorps
  • 4733401N12Rik anticorps
  • AI256641 anticorps
  • CFIM anticorps
  • CFIM68 anticorps
  • CPSF6 anticorps
  • HPBRII-4 anticorps
  • HPBRII-7 anticorps
  • wu:fa22f12 anticorps
  • zgc:85819 anticorps

Protein level used designations for CPSF6

cleavage and polyadenylation specific factor 6, 68kDa , cleavage and polyadenylation specificity factor subunit 6 , cleavage and polyadenylation specific factor 6, 68 kD subunit , CPSF 68 kDa subunit , cleavage and polyadenylation specificity factor 68 kDa subunit , cleavage factor Im complex 68 kDa subunit , pre-mRNA cleavage factor I, 68kD subunit , pre-mRNA cleavage factor Im (68kD) , pre-mRNA cleavage factor Im 68 kDa subunit , protein HPBRII-4/7

GENE ID SPECIES
452068 Pan troglodytes
446580 Xenopus laevis
548671 Xenopus (Silurana) tropicalis
100013834 Monodelphis domestica
100220791 Taeniopygia guttata
100589466 Nomascus leucogenys
327069 Danio rerio
432508 Mus musculus
417844 Gallus gallus
11052 Homo sapiens
474441 Canis lupus familiaris
100152191 Sus scrofa
768231 Bos taurus
299811 Rattus norvegicus
100174771 Pongo abelii
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