Collagen, Type VIII, alpha 2 (COL8A2) Kits ELISA

COL8A2 encodes the alpha 2 chain of type VIII collagen. De plus, nous expédions COL8a2 Anticorps (52) et COL8a2 Protéines (9) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
COL8A2 1296 P25067
COL8A2 329941 P25318
Anti-Rat COL8A2 COL8A2 313592  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Détails
Souris 7.81 pg/mL n/a   96 Tests 15 to 18 Days
$910.56
Détails

COL8a2 Kits ELISA mieux référencés

  1. Human COL8a2 Kit ELISA pour Sandwich ELISA - ABIN812960 : Ueno, Asada, Toda, Schlötzer-Schrehardt, Nagata, Montoya, Sotozono, Kinoshita, Hamuro: Gene Signature-Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells. dans Investigative ophthalmology & visual science 2016 (PubMed)

Plus Kits ELISA pour COL8a2 partenaires d'interaction

Human Collagen, Type VIII, alpha 2 (COL8A2) interaction partners

  1. Analysis of SLC4A11, ZEB1, LOXHD1, COL8A2 and TCF4 gene sequences in a multi-generational family with late-onset Fuchs corneal dystrophy found no evidence for found polymorophisms causing the disease in this specific pedigree.

  2. Peripheral, anterior microcystic corneal edema represents a characteristic aspect of the phenotype associated with the p.(Leu450Trp) substitution in COL8A2, in at least 2 of 3 known affected families worldwide.

  3. No mutations were identified in COL8A2, in neither the late-onset cohort nor the early-onset family, suggesting genetic heterogeneity in this Late-onset Fuchs endothelial corneal dystrophy (FECD) family.

  4. mutations in the COL8A2 gene do not contribute to all cases of early-onset early-onset Fuchs' endothelial corneal dystrophy .

  5. Variation in the COL8A2, SLC4A11, and ZEB1 genes is present in only a small fraction of African American cases and as such does not appear to significantly contribute to the genetic risk of Fuchs endothelial corneal dystrophy.

  6. Esophageal transcript profiling identified a distinct subset of genes, including COL8A2, in patients with Eosionophilic esophagitis and inherited connective tissue disorders.

  7. Association of central corneal thickness with TCF4 was also significant (p = 6.1x10(-7)), but was abolished with adjustment for FECD grade (p = 0.92).

  8. Single nucleotide polymorphisms in COL8A2 gene is not associated with central corneal thickness in glaucoma.

  9. Report cellular model in which collagen VIII mutations, which clinically result in Fuchs' dystrophy, are associated with abnormal cellular accumulation of collagen VIII.

  10. The purpose of this study is to evaluate COL8A1 and COL8A2 as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.

  11. These data constitute the first report of a heterozygous Q455V mutation of the COL8A2 gene in Korean patients with Fuchs' corneal dystrophy and Q455V may be the causative defect in the development and progression of Korean FECD patients.

  12. COL8A2, SLC4A11 genes may not be responsible for Fuchs endothelial corneal dystrophy in patients examined in this study.

  13. The R155Q and T502M mutations of COL8A2 may not be the causative defect in the Japanese Fuchs' endothelial corneal dystrophy and posterior polymorphous dystrophy patients examined in this study.

  14. No pathogenic mutations were identified in the COL8A2 gene or in several positional candidate genes in a series of patients, indicating that other genetic factors are involved in the development of this autosomal dominant corneal dystrophy.

  15. A novel pathogenic L450W COL8A2 mutation was identified and its highly distinctive pathology characterized. This indicates that COL8A2 mutations give rise to a rare subtype of FCD (Fuchs corneal dystrophy).

  16. Alpha2(VIII) collagen supported endothelial cell attachment in a dose-dependent manner, with an 18-fold higher affinity for endothelial cells.

  17. The absence of pathogenic mutations identified in the COL8A1 or COL8A2 genes in affected members of 15 pedigrees with familial FECD (Fuchs endothelial corneal dystrophy) indicates that other genetic factors are involved.

  18. Microscopic and electron microscopic examination revealed pathological changes in Descemet's membrane of L450W COL8A2 mutants that were consistent with several-fold increased growth of the extracellular matrix.

  19. The absence of pathogenic mutations in COL8A1 and COL8A2 in patients with keratoconus indicates that other genetic factors are involved in the pathogenesis of this corneal ectatic disorder.

  20. description of the phenotype of early-onset Fuchs' endothelial corneal dystrophy in a British family, which is caused by a point mutation (resulting in p.L450W substitution) in COL8A2

Mouse (Murine) Collagen, Type VIII, alpha 2 (COL8A2) interaction partners

  1. Overexpression of the Col8a2 gene in mouse and human Fuchs endothelial corneal dystrophy endothelial cells suggested a role for altered autophagy in this disease.

  2. in contrast to diabetic wild-type mice EMT-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice

  3. study confirms the Q455K substitution in the COL8A2 gene as being sufficient to cause FECD in the first mouse model of this disease and supports the role of the UPR and UPR-associated apoptosis in the pathogenesis of FECD caused by COL8A2 mutations

  4. Type VIII collagen significantly modulates the effect of TGF-beta1 on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.

  5. Smooth muscle cells can modify the matrix microenvironment by producing type VIII collagen, using it to overlay type I collagen, and generating a substrate favorable for migration

  6. Lack of type VIII collagen confers renoprotection in diabetic nephropathy in a knockout mouse model.

  7. The mouse mutant Aca23 described here offers the first point mutation of the Col8a2 gene and suggests that a functional collagen VIII alpha2 gene is essential for the correct assembly of the Descemet's membrane and for corneal stability.

COL8a2 (COL8A2) profil antigène

Antigen Summary

This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2.

Gene names and symbols associated with COL8A2

  • collagen type VIII alpha 2 chain (COL8A2) anticorps
  • collagen, type VIII, alpha 2 (Col8a2) anticorps
  • collagen type VIII alpha 2 chain (Col8a2) anticorps
  • AI429819 anticorps
  • FECD anticorps
  • FECD1 anticorps
  • PPCD anticorps
  • PPCD2 anticorps

Protein level used designations for COL8A2

collagen, type VIII, alpha 2 , collagen alpha-2(VIII) chain , collagen VIII, alpha-2 polypeptide , collagen type VIII alpha 2 , dJ665N4.1 (collagen type VIII alpha 2) , endothelial collagen , procollagen type VIII alpha 2 , procollagen, type VIII, alpha 2

GENE ID SPECIES
428221 Gallus gallus
539415 Bos taurus
747856 Pan troglodytes
1296 Homo sapiens
329941 Mus musculus
313592 Rattus norvegicus
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