Complement Component (3d/Epstein Barr Virus) Receptor 2 Protéines (CR2)

CR2 encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. De plus, nous expédions Complement Component (3d/Epstein Barr Virus) Receptor 2 Anticorps (490) et Complement Component (3d/Epstein Barr Virus) Receptor 2 Kits (38) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CR2 1380 P20023
CR2 289395  
CR2 12902  
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Top Complement Component (3d/Epstein Barr Virus) Receptor 2 Protéines sur anticorps-enligne.fr

Showing 10 out of 15 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Human Cells Humain His tag 100 μg Connectez-vous pour afficher 14 to 16 Days
$382.80
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 70 to 75 Days
$11,229.61
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Escherichia coli (E. coli) Humain His tag,GST tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$688.00
Détails
Escherichia coli (E. coli) Souris His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$765.00
Détails
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$800.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$814.00
Détails
HOST_HEK-293T Cells Humain His tag   100 μg Connectez-vous pour afficher 2 to 3 Days
$383.90
Détails
Levure Yeast His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,415.50
Détails
Escherichia coli (E. coli) Humain Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
Détails

CR2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
, ,

Plus protéines pour Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) partenaires d'interaction

Human Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) interaction partners

  1. Our data indicate that a distinct inflammatory process accompanies IL17A and CD21L co-expression. Clearly B-cells are involved and their prominence indicates that therapies targeting B-cells, such as rituximab, are likely to be more efficacious towards IL17A+/CD21L+ synovia.

  2. This study shown the C3d+ microglial clusters were found in chronic but not acute multiple sclerosis.

  3. This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.

  4. Binding of PF4/heparin complexes to B cells is mediated through the interaction between complement and complement receptor 2.

  5. high pERK expression and accelerated apoptosis revert within 4 weeks after beginning therapy, whereas clonal B cells unresponsive to TLR9 stimulation persist for at least 24 weeks, although they may partially rescue normal CD21 expression.

  6. Cerebrospinal fluid (CSF) soluble complement receptor 2 (sCR2) levels correlated significantly both with CSF complements C3 and C1q as well as to a disease severity measure.

  7. CR2 contributes to human Osteonecrosis of the femoral head susceptibility in Korean systemic lupus erythematosus patients.

  8. In this study, we have shown that the CR2 +24T>C polymorphism is not a risk marker for nasopharyngeal carcinoma development in the North region of Portugal.

  9. In mature B cells, CD21 transcription proceeds from a focused transcriptional start site regulated by a non-consensus TATA box, an initiator element and a downstream promoter element.

  10. Reduced expression of CD21 on CLL B-cells appears functionally relevant and was associated with poor clinical outcomes.

  11. These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus.

  12. repression of the CR2/CD21 promoter can occur through one of the E-box motifs via recruitment of RP58.

  13. found that the protective CR2 genotype is correlated with lower levels CR2 mRNA as well as differences in the ratio of the long and short CR2 isoforms

  14. The paradoxical enhancement of immune responses by C3d in the absence of CD21 is due to internalization and processing of C3d into peptides that activate autoreactive CD4(+) T-helper cells.

  15. THE COMBINATION OF EXPRESSION OF MARKERS CR1 AND CR2 (CD35/CD21) IN DIAGNOSTIC OF B-CELL LYMPHOPROLIFERATIVE DISEASES

  16. Higher C3d/C3 ratios were found for current smoker, higher age, age-related macular degeneration phenotype, and the two SNPs in the C3 gene, rs6795735 and rs2230199.

  17. Authors show that expression of the Epstein-Barr virus B-cell attachment receptor, CD21, in B cells that lack this receptor results in significant changes in gene expression, both before and rapidly following EBV-CD21 interaction.

  18. Our findings implicate CR2 as a susceptibility gene for nasopharyngeal carcinoma and suggest that enhanced CR2 expression may be involved in the oncogenesis and development of nasopharyngeal carcinoma.

  19. To eradicate this virus, targeting CD21 on these EBV-infected B cells is hypothesized here.

  20. Patients with primary Sjogren's Syndrome who display high frequencies of autoreactive and unresponsive CD21-/low B cells are susceptible to developing lymphoproliferation.

Cow (Bovine) Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) interaction partners

  1. Cattle express two major variants of the Cr2 gene representing homologues of murine CR1 and CR2, each of which is expressed in both a long and a short form.

Mouse (Murine) Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2) interaction partners

  1. These results demonstrate that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.

  2. Immunization of Cr1KO mice with a T cell-dependent antigen resulted in the normal initial expansion of B cells with a germinal center phenotype however these cells were preferentially lost in the Cr1KO animal over time (days).

  3. This study demonistrated that receptors for complement C3 fragments (CR2/CR1) may represent a promising future approach for therapeutic immunomodulation after traumatic brain injury.

  4. Data suggest that the Cr2KO mouse thus provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.

  5. Murine B cells predominantly express the Cr2 product from the Cr2 gene, whereas follicular dendritic cells (FDCs) almost exclusively express the Cr1 isoform generated from the Cr2 gene.

  6. Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization

  7. immune system uses three different CR1/2-mediated effector functions to generate optimal antibody responses

  8. Absence of CD21/35 protects mice from chronic wasting disease.

  9. We conclude that Cr2 regulates hippocampal neurogenesis

  10. There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H.

  11. Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.

  12. functionally significant phenotype for the NZM2410 Cr2 allele and strongly support its role as a lupus susceptibility gene

  13. Within the CD21 intronic control region, the formation of repeating, overlapping regulatory modules is required to coordinately control the B cell-specific expression of CD21.

  14. mouse bone marrow-derived mast cells express CD21

  15. CR2/CR1 play an unanticipated but critical role in the development of a subset of the natural Ab repertoire that has particular importance in the pathogenesis of IR injury.

  16. role of stromal cell complement receptors (CD21/CD35) and FcgammaRIIB receptors

  17. An in vivo system of intestinal ischemia-reperfusion injury reveals that mice deficient in Cr2 fail to mount an inflammatory response, as assessed by permeability index, survival, and histopathology.

  18. CD21/35 expression is critical for early protective antibody responses to lethal pathogens

  19. These results demonstrate a new B cell receptor-dependent pathway that is sufficient and perhaps necessary to provide a complement receptor 1/2 ligand that promotes efficient B cell activation.

  20. Mice deficient in CD35/CD21 showed a 67% decrease in survival compared with normal mice, suggesting that CD35/CD21 is of major importance in the control of S aureus-induced bacteremia.

Profil protéine Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2)

Profil protéine

This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CR2

  • complement C3d receptor 2 (CR2)
  • complement C3d receptor 2 (Cr2)
  • complement receptor 2 (Cr2)
  • C3DR Protéine
  • Cd21 Protéine
  • CD35 Protéine
  • CR Protéine
  • Cr-1 Protéine
  • Cr-2 Protéine
  • Cr1 Protéine
  • CVID7 Protéine
  • SLEB9 Protéine

Protein level used designations for CR2

EBV receptor , complement C3d receptor , complement receptor type 2 , epstein-Barr virus receptor , complement component receptor 2 , complement receptor 1 long isoform , complement receptor 2 , complement receptor type 1 , expressed in B lymphocytes

GENE ID SPECIES
1380 Homo sapiens
407126 Bos taurus
289395 Rattus norvegicus
12902 Mus musculus
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