anti-Complement Component 5a Receptor 1 (C5AR1) Anticorps

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. De plus, nous expédions C5AR1 Kits (10) et C5AR1 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
C5AR1 728 P21730
C5AR1 12273  
C5AR1 113959 P97520
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Top anti-C5AR1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 245 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of CD88 expression in A549 (A), mouse brain (B), rat spleen (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain, using CD88/C5aR (Phospho-Ser338) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué EIA, FACS, WB C5AR1 Antibody (Center) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. C5AR1 Antibody (Center) western blot analysis in A549 cell line lysates (35µg/lane).This demonstrates the C5AR1 antibody detected the C5AR1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Détails
Humain Rat Biotin FACS 0.1 mg 6 to 8 Days
$324.50
Détails
Humain Lapin Inconjugué IC, IF, IHC, WB   200 μL 13 to 14 Days
$487.50
Détails
Humain Chèvre Inconjugué ELISA, FACS, IF, WB ABIN5539670 (0.01µg/ml) staining of HepG2 cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence ABIN5539670 Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (4ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI ( 100 μg 6 to 7 Days
$429.84
Détails
Humain Lapin Inconjugué IF, IHC, ELISA, WB Western blot analysis of extracts from HeLa cells, treated with PMA 125ng/ml 30', using CD88/C5aR (Ab-338) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CD88/C5aR (Ab-338) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, IF, IHC, WB 100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of C5AR1 (Phospho-Ser334) using nocodazole treated COS7 whole cell lysates 100 μL 11 to 12 Days
$450.00
Détails

anti-C5AR1 Anticorps mieux référencés

  1. Human Monoclonal C5AR1 Primary Antibody pour IHC (f), IHC (fro) - ABIN2689428 : Fayyazi, Sandau, Duong, Götze, Radzun, Schweyer, Soruri, Zwirner: C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. dans The American journal of pathology 1999 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2689430 : Floreani, Heires, Welniak, Miller-Lindholm, Clark-Pierce, Rennard, Morgan, Sanderson: Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke. dans Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal C5AR1 Primary Antibody pour FACS, IP - ABIN1981892 : Camous, Roumenina, Bigot, Brachemi, Frémeaux-Bacchi, Lesavre, Halbwachs-Mecarelli: Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. dans Blood 2011 (PubMed)
    Show all 4 Pubmed References

  4. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour IHC (fro), FACS - ABIN2472739 : Zola, Melo, Zowtyj, Nikoloutsopoulos, Skinner: The leukocyte-common antigen (CD45) complex and B-lymphocyte activation. dans Human immunology 1990 (PubMed)
    Show all 4 Pubmed References

  5. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2472741 : Vaccaro, De Giorgi, Gallo, Vaccaro, Compare: [Various unusual morpho-pathologic cases of extrapulmonary tuberculosis]. dans Archivio Monaldi per le malattie del torace 1993 (PubMed)
    Show all 4 Pubmed References

  6. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2472748 : Soruri, Kim, Kiafard, Zwirner: Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. dans Immunology letters 2003 (PubMed)
    Show all 4 Pubmed References

  7. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2472751 : Godau, Heller, Hawlisch, Trappe, Howells, Best, Zwirner, Verbeek, Hogarth, Gerard, Van Rooijen, Klos, Gessner, Köhl: C5a initiates the inflammatory cascade in immune complex peritonitis. dans Journal of immunology (Baltimore, Md. : 1950) 2004 (PubMed)
    Show all 4 Pubmed References

  8. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2472743 : Shagdarsuren, Bidzhekov, Mause, Simsekyilmaz, Polakowski, Hawlisch, Gessner, Zernecke, Weber: C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice. dans Circulation 2010 (PubMed)
    Show all 4 Pubmed References

  9. Mouse (Murine) Monoclonal C5AR1 Primary Antibody pour FACS - ABIN2472745 : Manthey, Thomas, Shiels, Zernecke, Woodruff, Rolfe, Taylor: Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 (PubMed)
    Show all 4 Pubmed References

  10. Human Monoclonal C5AR1 Primary Antibody pour FACS, IHC (p) - ABIN1774738 : Cain, Monk: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). dans The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

Plus d’anticorps contre C5AR1 partenaires d’interaction

Human Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. CD14 blockade potentiated the effect of C5aR1 blockade, thus attenuating inflammation.

  2. Expression of C5aR1 and C5aR2 in whole blood was significantly attenuated by IL-6R-inhibition in non-ST-elevation myocardial infarction patients.

  3. This study aimed to investigate the role of C3aR and C5aR in these two diseases...Our data indicates that increased C3aR expression may lead to over activation of the Th17 cell response and may therefore contribute to the pathogenesis of Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH).

  4. our results demonstrate that human renal tubular epithelial C5aR1 signaling has a role in facilitating UPEC adhesion to and invasion of the epithelial cells through upregulation of Man expression and suggest that upregulation of Man is through C5aR1-mediated ERK1/2/NF-kappaB activation and release of proinflammatory cytokines

  5. In addition, an in vitro experiment revealed C5aR deficiency promoted the development of regulatory T cells whereas C5a activation abolished the differentiation of regulatory T cells.

  6. Furthermore, Apigenin reduced the proliferation of human NPC cells triggered by C5a through negative regulation of C5aR/PCAF/STAT3 axis. These might provide a new insight into the function of Apigenin in cancer treatment, and also provide a potential strategy for treating human NPC through inhibition of C5aR expression on cancer cells

  7. Low C5AR1 expression is associated with metastases of colon cancer.

  8. the role of the active fragment complement C5a receptor (C5aR) in dental nerve regeneration in regards to local secretion of nerve growth factor (NGF) upon carious injury.

  9. X ray structure of a thermostabilized C5aR1 (known as C5aR1 StaR) in complex with NDT9513727

  10. this study shows that C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA

  11. C5a-C5aR enriched clear cell renal cell carcinoma patients significantly had a poorer overall survival and recurrence free survival after nephrectomy.

  12. Serum containing active complement enhanced pneumococcal induced proinflammatory cytokine production through C5a release and C5aR crosstalk.

  13. C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21/p-p21 expression via activation of PI3K/AKT signaling.

  14. C5aR plays a role in T helper cell polarization induced by Mycobacterium tuberculosis and this effect is strain- and donor-dependent.

  15. Panton-Valentine leucotoxin LukS-PV/LukF-PV and the gamma-hemolysin HlgC/HlgB, bind the C5a complement-derived peptide receptor, inducing intracellular calcium release in neutrophils.

  16. Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.

  17. TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kbeta, SGK1, and FOXO transcription factors.

  18. Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 expression via PI3K and MEK. Study demonstrated expression of IL-8 and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.

  19. Reducing RPS19 in tumor cells or blocking the C5a receptor 1-RPS19 interaction decreases RPS19-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer

  20. C5aR expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.

Mouse (Murine) Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. The C5aR1- and TLR2-signalling pathways converge on the activation of p38 MAPK and the generation of C-X-C motif chemokine 10, which functions, among others, as an osteoclastogenic factor.

  2. C3aR and C5aR1 are potent regulators of ethanol-induced adipose inflammation in murine model of alcohol-related liver disease (ALD). C5aR1 modulates the impact of chronic ethanol on the content of the adipose secretome, likely contributing to intra-organ injury in ALD.

  3. Together, the data indicates that respiratory syncytial virus infection could apparently increase C5a and C5aR expression in the pathogenesis of respiratory syncytial virus-infected asthma mice, meanwhile C5a receptor antagonist prevents some of the CD4(+)T cells immune changes that are induced by respiratory syncytial virus.

  4. Taken together, this study shows distinct roles of C5aR1 and C5aR2 in a model of renal IRI with progressive renal fibrosis. Both C5aR1-/- and C5aR2-/- mouse strains, compared with WT mice, showed attenuated inflammation and fibrosis after IRI.

  5. These data indicate that MERS-CoV infection induces overactivation of complement, which may contribute to pyroptosis and inflammation. Pyroptosis and inflammation were suppressed by inhibiting C5aR1.

  6. in experimental renal fibrosis C5L2 and C5aR both contribute to tubular injury, and, while C5aR acts profibrotic, C5L2 does not play a role in extracellular matrix accumulation, arguing against C5L2 functioning simply as a decoy receptor

  7. Low C5AR1 expression is associated with metastases of colon cancer.

  8. the results define a previously unrecognized disease mechanism of C5aR activation in autoimmune hemolytic anemia that does not necessarily involve C5 and C5a.

  9. Together, these findings demonstrate that C5aR1 drives the pathophysiology associated with meningococcal sepsis and provides a promising target for adjunctive therapy.

  10. The present study indicates that hBM-MSCs alleviate AKI via suppressing C5a/C5aR-NF-kappaB pathway activation.

  11. Development of burn-induced mechanical allodynia, thermal allodynia, weight bearing changes and edema was assessed in C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice and compared to their wild type controls over three days. Burn-induced mechanical allodynia, thermal allodynia and weight bearing changes developed normally C3aR(-/-), C5aR1(-/-) and C5aR2(-/-) mice.

  12. C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

  13. These data indicate that blockade of the C5a-C5aR axis lead to the decreased tissue damage induced by MERS-CoV infection, as manifested by reduced apoptosis and T cell regeneration in the spleen.

  14. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  15. intracerebral hemorrhage induced complement activation, along with an increase of C5a/C5aR levels, microglia infiltration, and inflammatory cytokine levels. However, C5aR(-/-) mice exhibited significant attenuation of inflammatory reaction, accompanied by a remarkable reduction of Fgl-2, brain water content, and neurological dysfunction.

  16. We present evidence that mice deficient in C5aR or treated with AON-D21 are poor hematopoietic stem/progenitor cells mobilizers, thereby establishing a critical role for the C5a/C5adesArg-C5aR axis in the mobilization process.

  17. These data are consistent with microglial polarization in the absence of C5aR1 signaling reflecting decreased induction of inflammatory genes and enhancement of degradation/clearance pathways

  18. C5aR1 facilities the pathogenesis of chronic kidney infection by enhancement of bacterial colonization of tubular epithelium, promotion of local inflammatory responses, and impairment of phagocytic function of monocytes/macrophages.

  19. Data indicate that complement component 5a receptor 1 protein (C5aR1) signaling in osteoblasts plays a detrimental role in bone regeneration after fracture.

  20. The role of C5aR1 and C5aR2 in response to renal ischemia-reperfusion injury is reported. The results also demonstrated that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention.

Cow (Bovine) Complement Component 5a Receptor 1 (C5AR1) interaction partners

  1. Studies provide information regarding distinct structural and functional features that may contribute to the unique pharmacological properties of bovine C5aR.

C5AR1 profil antigène

Profil protéine

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Gene names and symbols associated with C5AR1

  • complement C5a receptor 1 (C5AR1) anticorps
  • complement component 5a receptor 1 (C5ar1) anticorps
  • complement C5a receptor 1 (C5ar1) anticorps
  • complement component 5a receptor 1 (c5ar1) anticorps
  • C5A anticorps
  • C5aR anticorps
  • C5r1 anticorps
  • Cd88 anticorps
  • D7Msu1 anticorps
  • GPR77 anticorps

Protein level used designations for C5AR1

C5a anaphylatoxin chemotactic receptor 1 , C5a anaphylatoxin receptor , C5a ligand , C5a-R , complement component 5 receptor 1 , complement component 5, receptor 1 , C5aR , complement C5a receptor , G protein-coupled receptor 77 , complement component 5 receptor 1 (C5a ligand) , C5a anaphylatoxin chemotactic receptor , anaphylatoxin C5a receptor , complement component 5a receptor 1

GENE ID SPECIES
728 Homo sapiens
12273 Mus musculus
113959 Rattus norvegicus
430484 Gallus gallus
442974 Canis lupus familiaris
468931 Pan troglodytes
493645 Bos taurus
718056 Macaca mulatta
100048955 Sus scrofa
100135489 Cavia porcellus
100379958 Xenopus (Silurana) tropicalis
100589337 Nomascus leucogenys
100352978 Oryctolagus cuniculus
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