anti-Complement Factor H-Related 4 (CFHR4) Anticorps

CFHR4 is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. De plus, nous expédions Complement Factor H-Related 4 Kits (3) et Complement Factor H-Related 4 Protéines (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CFHR4 10877 Q92496
CFHR4    
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Top anti-Complement Factor H-Related 4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 13 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Host:  Rabbit  Target Name:  FHR4  Sample Type:  721_B Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Souris Inconjugué CyTOF, FACS, ICC, WB Detection of Complement Factor H-related 4/CFHR4 in HepG2 Human Cell Line by Flow Cytometry. HepG2 human hepatocellular carcinoma cell line was stained with Human Complement Factor H-related 4/CFHR4 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with PFA and permeabilized with saponin. Detection of Human Complement Factor H-related 4/CFHR4 by Western Blot. Western blot shows lysates of human liver tissue. PVDF Membrane was probed with 2 ug/mL of Human Complement Factor H-related 4/CFHR4 Monoclonal Antibody. This experiment was conducted under non-reducing conditions. 100 μg Connectez-vous pour afficher 8 to 9 Days
$299.45
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB   100 μL Connectez-vous pour afficher 11 to 14 Days
$551.83
Détails
Humain Mouton Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 11 to 14 Days
$1,079.83
Détails
Humain Souris Alexa Fluor 647 FACS   100 μg Connectez-vous pour afficher 11 to 13 Days
$374.03
Détails
Humain Souris Alexa Fluor 350 FACS   100 μg Connectez-vous pour afficher 11 to 13 Days
$374.03
Détails
Humain Souris Alexa Fluor 750 FACS   100 μg Connectez-vous pour afficher 11 to 13 Days
$374.03
Détails
Humain Souris Alexa Fluor 594 FACS   100 μg Connectez-vous pour afficher 11 to 13 Days
$374.03
Détails

anti-Complement Factor H-Related 4 Anticorps mieux référencés

  1. Human Monoclonal CFHR4 Primary Antibody pour CyTOF, FACS - ABIN4899500 : Hebecker, Józsi: Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. dans The Journal of biological chemistry 2012 (PubMed)

Plus d’anticorps contre Complement Factor H-Related 4 partenaires d’interaction

Human Complement Factor H-Related 4 (CFHR4) interaction partners

  1. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR4]

  2. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  3. Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein

  4. Systemic lupus erythematosus were detected in European Americans and African Americans, which could be attributed to an intronic complement regulator factor H (CFH) single nucleotide polymorphism (SNP) and an intergenic SNP between CFHR1 and CFHR4.

  5. These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP and suggest a role for CFHR4 in enhancing opsonization via CRP binding.

  6. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.

  7. FHR-4A is a new Factor H-related protein with a unique domain composition, that is an internal duplication of four CCP domains FHR-4A provides the first evidence for alternative splicing among Factor H-related genes.

  8. These data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells.

Complement Factor H-Related 4 (CFHR4) profil antigène

Profil protéine

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.

Gene names and symbols associated with CFHR4

  • complement factor H related 4 (CFHR4) anticorps
  • CFHL4 anticorps
  • FHR-4 anticorps
  • FHR4 anticorps

Protein level used designations for CFHR4

complement factor H-related protein 4

GENE ID SPECIES
10877 Homo sapiens
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