anti-Complement Factor H-Related 4 (CFHR4) Anticorps

CFHR4 is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. De plus, nous expédions Complement Factor H-Related 4 Kits (3) et Complement Factor H-Related 4 Protéines (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CFHR4 10877 Q92496
CFHR4    
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Top anti-Complement Factor H-Related 4 Anticorps sur anticorps-enligne.fr

Showing 5 out of 6 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué WB 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB Host:  Rabbit  Target Name:  FHR4  Sample Type:  721_B Whole Cell lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué WB   100 μL 11 to 14 Days
$551.83
Détails
Humain Mouton Inconjugué ELISA, WB   100 μg 11 to 14 Days
$1,079.83
Détails

anti-Complement Factor H-Related 4 Anticorps mieux référencés

  1. Human Monoclonal CFHR4 Primary Antibody pour CyTOF, FACS - ABIN4899500 : Hebecker, Józsi: Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. dans The Journal of biological chemistry 2012 (PubMed)

Plus d’anticorps contre Complement Factor H-Related 4 partenaires d’interaction

Human Complement Factor H-Related 4 (CFHR4) interaction partners

  1. The SNP rs3753396 in CFH and SNP rs6685931 in CFHR4 are associated with systemic complement activation levels. The SNP rs6685931 in CFHR4 and its linked haplotype H1-2 also conferred a risk for age-related macular degeneration (AMD) development, and therefore could be used to identify AMD patients who would benefit most from complement-inhibiting therapies.

  2. Reports an association between a rare variant in the complement factor H-related 4 (CFHR4) gene and phenytoin-induced maculopapular exanthema in Europeans. This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity.

  3. The combination of three proteins - apolipoprotein A-IV, complement factor H-related protein 4 and platelet basic protein - demonstrated the best classification performance for our data for diagnosis of growth hormone defic.

  4. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR4]

  5. Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.

  6. Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein

  7. Systemic lupus erythematosus were detected in European Americans and African Americans, which could be attributed to an intronic complement regulator factor H (CFH) single nucleotide polymorphism (SNP) and an intergenic SNP between CFHR1 and CFHR4.

  8. These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP and suggest a role for CFHR4 in enhancing opsonization via CRP binding.

  9. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.

  10. FHR-4A is a new Factor H-related protein with a unique domain composition, that is an internal duplication of four CCP domains FHR-4A provides the first evidence for alternative splicing among Factor H-related genes.

  11. These data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells.

Complement Factor H-Related 4 (CFHR4) profil antigène

Profil protéine

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.

Gene names and symbols associated with CFHR4

  • complement factor H related 4 (CFHR4) anticorps
  • CFHL4 anticorps
  • FHR-4 anticorps
  • FHR4 anticorps

Protein level used designations for CFHR4

complement factor H-related protein 4

GENE ID SPECIES
10877 Homo sapiens
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