anti-Cone-Rod Homeobox (CRX) Anticorps

The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. De plus, nous expédions Cone-Rod Homeobox Protéines (10) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CRX 1406 O43186
CRX 60446  
CRX 12951 O54751
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Top anti-Cone-Rod Homeobox Anticorps sur anticorps-enligne.fr

Showing 10 out of 50 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Souris Inconjugué ELISA, WB CRX monoclonal antibody (M02), clone 4G11 Western Blot analysis of CRX expression in IMR-32 . Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M02), clone 4G11.<br><br>Lane 1: CRX transfected lysate(32 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of CORD2 using anti-CORD2 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: HEPG2 whole cell lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CORD2 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CORD2 at approximately 37KD. The expected band size for CORD2 is at 32KD. 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué WB Host: Rabbit Target Name: CRX Sample Type: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Souris Inconjugué ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.19 KDa) . Dilution: 1:500~1000 100 μg Connectez-vous pour afficher 8 to 11 Days
$461.00
Détails
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Western Blot: CORD2 Antibody [NBP1-88059] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY424645) Immunocytochemistry/Immunofluorescence: CORD2 Antibody [NBP1-88059] - Staining of human cell line U-251 MG shows positivity in nucleoli. 0.1 mL Connectez-vous pour afficher 34 Days
$491.63
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Immunohistochemistry-Paraffin: CORD2 Antibody [NBP1-88060] - Staining of human kidney shows strong cytoplasmic positivity in tubular cells. Western Blot: CORD2 Antibody [NBP1-88060] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY424645) 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$491.63
Détails
Rat Chèvre Inconjugué ELISA, WB ABIN1590000 (1 µg/mL) staining of Rat Retina lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 6 to 7 Days
$358.02
Détails
Humain Lapin Inconjugué WB Western Blot: CORD2 Antibody [NBP2-15964] - Sample (30 ug of whole cell lysate) A: SK-N-SH 12% SDS PAGE gel, diluted at 1:1000. Western Blot: CRX/CORD2 Antibody  - Whole cell extract (30 ug) was separated by 12% SDS-PAGE, and the membrane was blotted with CORD2 antibody diluted at 1:1000. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$514.63
Détails
Humain Souris Inconjugué RNAi, ELISA, WB Western Blot analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M01), clone F6-C2.<br><br>Lane 1: CRX transfected lysate(32.261 KDa).<br>Lane 2: Non-transfected lysate.<br> Detection limit for recombinant GST tagged CRX is approximately 1ng/ml as a capture antibody. 100 μg Connectez-vous pour afficher 11 to 12 Days
$440.00
Détails
Humain Lapin Inconjugué WB Western blot analysis of lysate from Y79 cell line, using CRX Antibody at 1:1000. 400 μL Connectez-vous pour afficher 2 to 3 Days
$515.63
Détails

anti-Cone-Rod Homeobox Anticorps mieux référencés

  1. Human Monoclonal CRX Primary Antibody pour ELISA, WB - ABIN560473 : Peng, Chen: Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. dans Human molecular genetics 2007 (PubMed)
    Show all 10 Pubmed References

  2. Human Monoclonal CRX Primary Antibody pour ELISA, WB - ABIN514613 : Terrell, Xie, Workman, Mahato, Zelhof, Gebelein, Cook: OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. dans Developmental dynamics : an official publication of the American Association of Anatomists 2011 (PubMed)

  3. Human Monoclonal CRX Primary Antibody pour RNAi, ELISA - ABIN560472 : Gong, Sagiv, Cai, Tsang, Del Priore: Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. dans Experimental eye research 2008 (PubMed)

Plus d’anticorps contre Cone-Rod Homeobox partenaires d’interaction

Zebrafish Cone-Rod Homeobox (CRX) interaction partners

  1. CRX can influence the development and opsin (Montrer RHO Anticorps) expression of photoreceptor outer segments in zebrafish.

  2. The CRX protein can recognize the BAT 1 (Montrer DDX39B Anticorps) regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.

  3. No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.

Human Cone-Rod Homeobox (CRX) interaction partners

  1. we revealed a novel frameshift mutation (NM_000554.4:c.538dupG:p.Val180fs) in exon 4 of the CRX gene in a Chinese family with Cone-rod dystrophy. This study broadens the known pathogenic mutation spectrum of the CRX gene and contributes to improved genetic counseling for Cone-rod dystrophy patients.

  2. analysis of a homozygous nonsense mutation in SAMD11 (Montrer SAMD11 Anticorps) in five individuals diagnosed with adult-onset retinitis pigmentosa; SAMD11 (Montrer SAMD11 Anticorps) interacts with CRX and is expressed in retina

  3. CRX mutations are associated with a variety of clinical phenotypes, including an adult-onset macular dystrophy that simulates benign concentric annular macular dystrophy with a bull's eye macular lesion and fairly well preserved visual acuity.

  4. data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.

  5. Loss of OTX2 (Montrer OTX2 Anticorps) expression resulted in decreased expression of C-MYC (Montrer MYC Anticorps) and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 (Montrer OTX2 Anticorps) expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation

  6. Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.

  7. Con (Montrer DISP1 Anticorps) rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.

  8. Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.

  9. Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.

  10. CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors

Cow (Bovine) Cone-Rod Homeobox (CRX) interaction partners

  1. OTR1 (Montrer OXTR Anticorps), OTX2 (Montrer OTX2 Anticorps) and CRX act as positive modulators of the BEST1 (Montrer BEST1 Anticorps) promoter in the retinal pigment epithelium.

Mouse (Murine) Cone-Rod Homeobox (CRX) interaction partners

  1. CRX is required for chromatin remodeling at only a subset of its binding sites, which undergo retina or neuronal specific activation during photoreceptor differentiation.

  2. proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes.

  3. The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.

  4. CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.

  5. Rax (Montrer RAX Anticorps) and Crx cooperatively transactivate Rhodopsin (Montrer RHO Anticorps) and cone opsin (Montrer RHO Anticorps) promoters and an optimum Rax (Montrer RAX Anticorps) expression level to transactivate photoreceptor gene expression exists.

  6. E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.

  7. The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat (Montrer AANAT Anticorps) expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis

  8. We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2 (Montrer KCNV2 Anticorps).

  9. In Crx-knockout mice vasopressin (Montrer AVP Anticorps) mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.

  10. Data have identified a novel retinal SAM (Montrer TTN Anticorps) domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.

Cone-Rod Homeobox (CRX) profil antigène

Profil protéine

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Gene names and symbols associated with anti-Cone-Rod Homeobox (CRX) Anticorps

  • cone-rod homeobox (crx) anticorps
  • cone-rod homeobox (CRX) anticorps
  • cone-rod homeobox (Crx) anticorps
  • CORD2 anticorps
  • CRD anticorps
  • CRX anticorps
  • Crx1 anticorps
  • LCA7 anticorps
  • OTX3 anticorps
  • otx5 anticorps
  • otx5b anticorps
  • rx anticorps
  • Xotx5 anticorps
  • Xotx5b anticorps

Protein level used designations for anti-Cone-Rod Homeobox (CRX) Anticorps

cone-rod homeobox , homeobox protein otx5 , orthodenticle homolog 5 , cone-rod homeobox protein , orthodenticle homeobox 3 , crx gene for cone-rod homeobox protein , photoreceptor-specific cone-rod homeobox protein , cone-rod homeobox containing

GENE ID SPECIES
81881 Danio rerio
468934 Pan troglodytes
548775 Xenopus (Silurana) tropicalis
554246 Monodelphis domestica
717550 Macaca mulatta
100379624 Felis catus
1406 Homo sapiens
280756 Bos taurus
403577 Canis lupus familiaris
60446 Rattus norvegicus
12951 Mus musculus
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