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The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. De plus, nous expédions Cone-Rod Homeobox Protéines (8) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal CRX Primary Antibody pour ELISA, WB - ABIN560473
Peng, Chen: Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. dans Human molecular genetics 2007
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Human Monoclonal CRX Primary Antibody pour ELISA, WB - ABIN514613
Terrell, Xie, Workman, Mahato, Zelhof, Gebelein, Cook: OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. dans Developmental dynamics : an official publication of the American Association of Anatomists 2011
Human Monoclonal CRX Primary Antibody pour RNAi, ELISA - ABIN560472
Gong, Sagiv, Cai, Tsang, Del Priore: Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. dans Experimental eye research 2008
CRX can influence the development and opsin (Montrer RHO Anticorps) expression of photoreceptor outer segments in zebrafish.
The CRX protein can recognize the BAT 1 (Montrer DDX39B Anticorps) regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.
No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.
analysis of a homozygous nonsense mutation in SAMD11 (Montrer SAMD11 Anticorps) in five individuals diagnosed with adult-onset retinitis pigmentosa; SAMD11 (Montrer SAMD11 Anticorps) interacts with CRX and is expressed in retina
CRX mutations are associated with a variety of clinical phenotypes, including an adult-onset macular dystrophy that simulates benign concentric annular macular dystrophy with a bull's eye macular lesion and fairly well preserved visual acuity.
data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.
Loss of OTX2 (Montrer OTX2 Anticorps) expression resulted in decreased expression of C-MYC (Montrer MYC Anticorps) and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 (Montrer OTX2 Anticorps) expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation
Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.
Con (Montrer DISP1 Anticorps) rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.
Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.
Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.
CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors
Data have identified a novel retinal SAM (Montrer TTN Anticorps) domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.
OTR1 (Montrer OXTR Anticorps), OTX2 (Montrer OTX2 Anticorps) and CRX act as positive modulators of the BEST1 (Montrer BEST1 Anticorps) promoter in the retinal pigment epithelium.
proteins involved in phototransduction were not detected in the Crx(-/-) mouse; in this phenotype, however, proteins from spots showing diurnal rhythms were specifically identified as enzymes involved in glucose metabolism, Krebs cycle, and mitochondrial enzymes.
The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.
CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.
Rax (Montrer RAX Anticorps) and Crx cooperatively transactivate Rhodopsin (Montrer RHO Anticorps) and cone opsin (Montrer RHO Anticorps) promoters and an optimum Rax (Montrer RAX Anticorps) expression level to transactivate photoreceptor gene expression exists.
E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.
The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat (Montrer AANAT Anticorps) expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis
We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2 (Montrer KCNV2 Anticorps).
In Crx-knockout mice vasopressin (Montrer AVP Anticorps) mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.
Our results show that NRL (Montrer NRL Anticorps) and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis (Montrer CISH Anticorps)-regulatory module
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
, homeobox protein otx5
, orthodenticle homolog 5
, cone-rod homeobox protein
, orthodenticle homeobox 3
, crx gene for cone-rod homeobox protein
, photoreceptor-specific cone-rod homeobox protein
, cone-rod homeobox containing