anti-Creatine Kinase, Brain (CKB) Anticorps

The protein encoded by CKB is a cytoplasmic enzyme involved in energy homeostasis. De plus, nous expédions Creatine Kinase, Brain Kits (51) et Creatine Kinase, Brain Protéines (34) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CKB 1152 P12277
CKB 12709 Q04447
CKB 24264 P07335
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Chèvre Inconjugué ELISA, WB ABIN185601 (0.1µg/ml) staining of human brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit  Target Name: CKB  Sample Tissue: Human Fetal Brain  Antibody Dilution: 1.0 µg/mL 100 μL 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image Sample(30 μg of whole cell lysate) A:H1299 B:HeLa S3, 12% SDS PAGE antibody diluted at 1:1000 WB Image Creatine kinase (brain) antibody detects Creatine kinase protein by western blot analysis. Rat tissue extracts (50 μg) was separated by 10 % SDS-PAGE, and blotted with Creatine kinase (brain) antibody , diluted by 1:1000 100 μL 3 to 4 Days
Humain Lapin Inconjugué ICC, IF, IHC (p), WB WB Image Sample (30μg whole cell lysate) A:H1299 10% SDS PAGE antibody diluted at 1:1000 WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 10% SDS PAGE Creatine Kinase BB antibody antibody diluted at 1:1000 100 μL 3 to 4 Days
Humain Lapin Inconjugué ELISA, IHC, WB Western blot analysis of CKB using anti-CKB antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates,  Lane 2: human placenta tissue lysates, Lane 3: human COLO-320 whole cell lysates,  Lane 4: human SW620 whole cell lysates,  Lane 5: human MDA-MB-231 whole cell lysates,  Lane 6: rat brain tissue lysates, Lane 7: mouse brain tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CKB antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CKB at approximately 45KD. The expected band size for CKB is at 43KD. IHC analysis of CKB using anti-CKB antibody . CKB was detected in paraffin-embedded section of human colon cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-CKB Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 to 6 Days
Chien Chèvre Inconjugué ELISA, WB 100 μg 11 to 14 Days
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from Jurkat, using Phospho-CKB(S199) Antibody. 100 μL 11 to 12 Days
Roussette (Chauve-souris) Lapin Inconjugué WB 100 μL 11 to 14 Days
Chien Lapin Inconjugué WB 100 μL 11 to 14 Days

anti-Creatine Kinase, Brain Anticorps mieux référencés

  1. Human Monoclonal CKB Primary Antibody pour WB - ABIN532705 : Newby: Markers of cardiac ischemia, injury, and inflammation. dans Progress in cardiovascular diseases 2004 (PubMed)
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  2. Human Polyclonal CKB Primary Antibody pour IHC, IHC (p) - ABIN4300404 : Mello, Leal, Rey, Pinto, Lamarão, Montenegro, Alves, Assumpção, Borges, Smith, Burbano: Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis. dans PLoS ONE 2015 (PubMed)
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  3. Human Monoclonal CKB Primary Antibody pour IHC (fro), IHC (p) - ABIN2191988 : Sistermans, de Kok, Peters, Ginsel, Jap, Wieringa: Tissue- and cell-specific distribution of creatine kinase B: a new and highly specific monoclonal antibody for use in immunohistochemistry. dans Cell and tissue research 1995 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal CKB Primary Antibody pour IHC (fro), IHC (p) - ABIN2191989 : de Kok, Geurds, Sistermans, Usmany, Vlak, Wieringa: Production of native creatine kinase B in insect cells using a baculovirus expression vector. dans Molecular and cellular biochemistry 1995 (PubMed)
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  5. Dog (Canine) Polyclonal CKB Primary Antibody pour ELISA, WB - ABIN547645 : Balasubramani, Day, Schoen, Getzenberg: Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. dans Cancer research 2006 (PubMed)

  6. Human Polyclonal CKB Primary Antibody pour ELISA, WB - ABIN560380 : Hara, Aizaki, Matsuda, Shinkai-Ouchi, Inoue, Murakami, Shoji, Kawakami, Matsuura, Lai, Miyamura, Wakita, Suzuki: Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. dans Journal of virology 2009 (PubMed)

Plus d’anticorps contre Creatine Kinase, Brain partenaires d’interaction

Human Creatine Kinase, Brain (CKB) interaction partners

  1. The data revealed a varying but significant increase of CK activity in CKBE individuals as compared to controls, reaching an almost 800-fold increase in two CKBE individuals which also had increased erythrocyte creatine.

  2. Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress.

  3. membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations.

  4. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.

  5. SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression.

  6. CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups.

  7. CK-B catalytic activity also helps in the formation of protrusive ruffle structures which are actin-dependent and abundant on the surface of both unstimulated and LPS-activated macrophages.

  8. increased serum Ckbb reflects failure of osteoclasts or suppression of osteoclasts in children with osteogenesis imperfecta during neridronate treatment

  9. Estimation of CK and its CK isoenzyme fractions can aid in quick and accurate diagnosis of tubal ectopic pregnancy.

  10. effects of osmolytes on human brain-type creatine kinase folding

  11. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B.

  12. analysis of SNPs and their effect on creatine kinase structure and function

  13. study found promoter SNPs of CKB and TPI1 were weakly associated with schizophrenia;in addition, IFNG polymorphisms were associated with schizophrenia; results suggest that IFNG and proteins affected by IFNG may play a role in the pathogenesis of schizophrenia

  14. de-methylated CKB gene is inherited that leads to high CKB expression levels in myeloic precursor cells in the bone marrow

  15. His103 and Phe107 in hASB9-2 are essential for binding to CKB.

  16. Cigarette smoke induced carbonylation and subsequent degradation of creatine kinase B are involved in the regulation of senescence in bronchial epithelial cells.

  17. The results suggested that the intra- and inter-subunit domain interactions modified the behavior of kinetic refolding.

  18. Data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT.

  19. CKB was up-regulated in women older than 38 years, and its expression in cumulus cells was associated with embryo quality

  20. These observations suggested that the ability to generate the oxidized form could protect BBCK against the intracellular oxidative stress.

Rabbit Creatine Kinase, Brain (CKB) interaction partners

  1. The effect of Zn(2+) on the folding and aggregation of brain creatine kinase (CK-BB), was studied.

  2. report the identity of a 45 kDa imidazoline binding protein to be brain creatine kinase and this enzyme possesses an I2 binding site; findings will undoubtedly contribute to greater understanding of and development of imidazoline therapeutic drugs.

Mouse (Murine) Creatine Kinase, Brain (CKB) interaction partners

  1. Loss of normal CKB structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.

  2. CKB plays a key role in myotube formation by limiting myoblast fusion during myogenesis.

  3. BCK phosphorylation at Ser6 did not affect its enzymatic activity, but led to the appearance of the phosphorylated enzyme at the endoplasmic reticulum (ER)

  4. Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation

  5. negative regulation of CKB by mHTT is a key event in the pathogenesis of HD and contributes to the neuronal dysfunction associated with HD.

  6. reduced expression of brain creatine kinase in the cochlea of Huntington disease mice is associated with hearing impairment

  7. The comparison of protein patterns obtained with neural and non-neural derivatives of EC cell lines indicates changes are specific for the neural pathway, including the accumulation of the brain isozyme of creatine phosphokinase.

  8. In rat cerebrum and cerebellum, as in rat heart, at all ages the several cCK isoenzymes do participate in a gender-specific manner, in favor of females, in diverse functions of the different cell compartments of glial and neuronal cells.

  9. CK-B was expressed selective to astrocytes among glial populations, and was exclusive to inhibitory neurons among neuronal populations.

  10. Brain type and mitochondrial ubiquitous CK double knockout mice have a reduced body weight, and demonstrate a severely impaired spatial learning in both a dry and a wet maze, lower nestbuilding activity and diminished acoustic startle reflex responses.

  11. Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.

  12. cytoskeletal dynamics during cell motility is coupled to on-site availability of ATP generated by CKB

  13. Here, we report on the coupling of CK activity to body temperature rhythm and adaptive thermoregulation

Creatine Kinase, Brain (CKB) profil antigène

Profil protéine

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.

Gene names and symbols associated with CKB

  • creatine kinase B (CKB) anticorps
  • creatine kinase, brain L homeolog (ckb.L) anticorps
  • creatine kinase B-type (CKB) anticorps
  • creatine kinase, brain (Ckb) anticorps
  • creatine kinase, brain (ckb) anticorps
  • creatine kinase, brain b (ckbb) anticorps
  • creatine kinase, brain (CKB) anticorps
  • creatine kinase B (Ckb) anticorps
  • b-ck anticorps
  • bck anticorps
  • cb594 anticorps
  • Ck-3 anticorps
  • Ck3 anticorps
  • ckb anticorps
  • Ckbb anticorps
  • Ckbr anticorps
  • wu:fj36f10 anticorps
  • wu:fj37d11 anticorps

Protein level used designations for CKB

creatine kinase B chain , creatine kinase B-type , creatine kinase-B , B-CK , brain creatine kinase , creatine kinase, brain , creatine kinase B , B-creatine kinase , alternate protein , brain creatine kinase b , Creatine kinase B chain , Creatine kinase B-type

1152 Homo sapiens
100009085 Oryctolagus cuniculus
380055 Xenopus laevis
100190977 Ovis aries
453185 Pan troglodytes
516210 Bos taurus
12709 Mus musculus
733543 Xenopus (Silurana) tropicalis
396248 Gallus gallus
140744 Danio rerio
711167 Macaca mulatta
24264 Rattus norvegicus
100627332 Sus scrofa
100735800 Cavia porcellus
100855552 Canis lupus familiaris
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