Creatine Kinase, Muscle Protéines (CKM)

The protein encoded by CKM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. De plus, nous expédions Creatine Kinase, Muscle Anticorps (394) et Creatine Kinase, Muscle Kits (148) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CKM 1158 P06732
CKM 12715 P07310
CKM 24265 P00564
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Showing 10 out of 49 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Sanglier His tag,GST tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Chien His tag 100 μg 15 to 18 Days
Escherichia coli (E. coli) Rat His tag 100 μg 15 to 18 Days
Human Cells Humain His tag   50 μg 4 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Humain His tag 50 μg 14 to 16 Days
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human CKM Protein. 100 μg 11 to 18 Days

CKM Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , , ,
, ,
Mouse (Murine)

Rat (Rattus) , ,

Creatine Kinase, Muscle Protéines mieux référencés

  1. Human CKM Protein expressed in Escherichia coli (E. coli) - ABIN624669 : Mitsakakis, Gizeli: Detection of multiple cardiac markers with an integrated acoustic platform for cardiovascular risk assessment. dans Analytica chimica acta 2011 (PubMed)

Plus protéines pour Creatine Kinase, Muscle (CKM) partenaires d'interaction

Human Creatine Kinase, Muscle (CKM) interaction partners

  1. elevated CK-MB value is a common finding in RV-infection and completely mediated by the severity of diarrhea. CK-MB monitoring may help to identify children with more severe viral infection.

  2. The formation of insoluble aggregates would decrease levels of active Creatine kinase (CK) which may provide clues in CK deficiency disease. Moreover, these results indicated that the degree of synergism had closely relationship to the conformational changes of CK

  3. Low CK-MB expression is associated with ST-Segment Elevation Myocardial Infarction.

  4. On admission, high-sensitivity troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.

  5. A genetic factor known to be associated with constitutive creatine kinase levels is also associated with creatine kinase variability and inducibility and the variant has an impact on inducibility of creatine kinase by trauma through a homozygous carrier.

  6. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.

  7. Marathoners with a lower CKMM response after the race had a more favorable polygenic profile than runners with high serum CKMM concentrations. This might suggest a significant role of genetic polymorphisms in the levels of exertional muscle damage and rhabdomyolysis.

  8. Myocardial Creatine Kinase is a significant independent predictor of 6-month left ventricle remodeling in myocardial infarction patients.

  9. A positive association was found between PANSS-total and sCK [serum creatine kinase] in SzA [schizoaffective disorder] and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.

  10. These results demonstrate an association between physical performance measures and genetic variation in the muscle-specific creatine kinase gene (rs8111989).

  11. Muscle pain induced by simvastatin resulted in increased levels of creatine kinase compared to non-treated patients.

  12. Data show that a low serum creatine kinase activity is more common in female than male, and is associated with older age.

  13. CK-MB mass is more significant criteria of myocardial injury.

  14. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants

  15. CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups.

  16. The serum expression levels of myocardial creatine kinase and of galectin-3 reflect the physiopathology state of children with congenital heart defects after surgical correction.

  17. The variant rs11559024 in the CKM gene (Glu83Gly) was significantly associated with CK levels of statin users.

  18. elderly women classified as high response experienced greater serum response to eccentric resistance exercise

  19. Based on the obtained results, it may be speculated that the CKM A/G polymorphism is not an important determinant of endurance performance level in Polish and Russian rowers.

  20. Substantive creatine phosphokinase increases and rhabdomyolysis with statin use were particularly seen in patients starting treatment, those on large daily doses or interacting drugs or with larger numbers of concomitant drugs

Mouse (Murine) Creatine Kinase, Muscle (CKM) interaction partners

  1. We conclude that ILK negatively and independently of PI3K regulated MEF2C phosphorylation activity and MCK mRNA expression in C2C12 cells

  2. The Fxn KO/Mck mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills.

  3. PI3K and AKT regulated skeletal muscle differentiation by regulating the expression of Myogenin and MCK.

  4. CK-M overexpression led to significantly increased contractile function at baseline and during adrenergic stimulation and increased survival after thoracic aortic constriction-induced heart failure.

  5. strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin

  6. These studies indicate that the age-associated oxidative and nitrative modification of CKm results in a decrease in its activity and may cause structural changes that promote oligomerization and aggregation.

  7. Not involved in levels of creatine nnd creatine kinase in skeletal muscle of knockout mice.

  8. one of the consequences of M-CK and AK1 deficiency is hampered phosphoryl delivery to the actomyosin ATPase, resulting in a loss of contractile performance.

  9. Allosteric activation of phosphorylase b accounts for the accelerated glycogenolysis in CK-/- muscle during contraction.

  10. Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase enhancer

  11. the expression of muscle creatine kinase (MCK) gene in the heart and skeletal muscle of mice during aging

  12. metabolic failure induced by CK deficiency profoundly affects the ability of mice to engage in chronic bouts of endurance running exercise and that this decrease in performance is also associated with muscle wasting

  13. CK-MM autoantibodies can modulate the rate of CK clearance from the circulation in myositis

  14. Data show that spatial relations among organelles of muscle cells undergo adaptation in response to nonstructural stimuli such as metabolic (creatine kinase)deficiency.

  15. The creatine kinase energy transport system was evaluated in the failing mouse heart.

  16. Dec proteins repressed a MyoD-activated promoter activity of muscle creatine kinase gene through class A E-box in an HDAC1-independent manner.

  17. Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.

Xenopus laevis Creatine Kinase, Muscle (CKM) interaction partners

  1. These data demonstrate that initial phosphocreatine hydrolysis in single skeletal muscle fibers is crucial for maintenance of sarcoplasmic reticulum Ca2+ release and peak tension during a bout of repetitive tetanic contractions.

Pig (Porcine) Creatine Kinase, Muscle (CKM) interaction partners

  1. this study examined the heterogeneity of creatine kinase (CK) forward flux rate of hearts with postinfarction left ventricular (LV) remodeling.

Rabbit Creatine Kinase, Muscle (CKM) interaction partners

  1. water molecules affect protein conformation around residue 268, thereby influencing protein stability at low temperature

  2. role of linker on the isolated C-terminal domain of rabbit muscle creatine kinase

  3. when gly(268) in rabbit muscle-specific creatine kinase was substituted with asn(268), the rabbit muscle-specific CK G286N mutant specific activity at pH 8.0 and 10 degrees C was more than 2-fold higher than that in the wild-type rabbit enzyme

  4. Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates.

  5. In addition to its role in the in vivo functions, the linker also played a crucial role in the stability and folding of CKM.

  6. Changing the substrate specificity of creatine kinase from creatine to glycocyamine.

  7. There are three conformations of CK arranged according to the "energy minimizing principle" by ligated substrates.

  8. These results suggested that the electrostatic interactions were crucial to the action of the linker in CK reactivation.

  9. Study work provides evidence that the presence at the air/water interface of discrete domains with increased charge density, may lead to difference in partition of soluble proteins such as mtCK, interacting with the lipid monolayer.

Profil protéine Creatine Kinase, Muscle (CKM)

Profil protéine

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.

Gene names and symbols associated with CKM

  • creatine kinase, M-type (CKM)
  • creatine kinase, muscle (Ckm)
  • creatine kinase, M-type (Ckm)
  • creatine kinase, M-type L homeolog (ckm.L)
  • creatine kinase, M-type (ckm)
  • creatine kinase, muscle (CKM)
  • creatine kinase, muscle a (ckma)
  • creatine kinase, muscle b (ckmb)
  • cb51 Protéine
  • CK-M Protéine
  • ckm Protéine
  • ckm3 Protéine
  • ckmm Protéine
  • m-ck Protéine
  • mck Protéine
  • wu:fa28d05 Protéine
  • wu:fb55e09 Protéine
  • zgc:64204 Protéine
  • zgc:92070 Protéine

Protein level used designations for CKM

creatine kinase M chain , creatine kinase M-type , Creatine kinase, muscle form , M-CK , muscle creatine kinase , B-creatine kinase , Creatine kinase M chain , Creatine kinase M-type , creatine kinase, muscle , creatine kinase M-type-like , muscle creatine kinase a

1158 Homo sapiens
12715 Mus musculus
24265 Rattus norvegicus
286822 Bos taurus
379765 Xenopus laevis
395005 Xenopus (Silurana) tropicalis
396507 Gallus gallus
397264 Sus scrofa
476435 Canis lupus familiaris
723486 Macaca mulatta
744935 Pan troglodytes
100009056 Oryctolagus cuniculus
100406693 Callithrix jacchus
100455238 Pongo abelii
30095 Danio rerio
101112841 Ovis aries
100733577 Cavia porcellus
794752 Danio rerio
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