anti-Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Anticorps

The protein encoded by CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. De plus, nous expédions Cyclin-Dependent Kinase 2 Associated Protein 1 Protéines (12) et Cyclin-Dependent Kinase 2 Associated Protein 1 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
CDK2AP1 13445 O35207
CDK2AP1 8099 O14519
CDK2AP1 360804  
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Top anti-Cyclin-Dependent Kinase 2 Associated Protein 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 58 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Poulet Lapin Inconjugué WB Western blot analysis of CDK2AP1 expression in HUVEC (A), HeLa (B) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB Western blot analysis of extracts from HeLa cells, using CDKPA1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE) 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, WB ABIN6266688 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis on HeLa cell lysate using CDKAP1 Antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL Connectez-vous pour afficher 11 to 12 Days
$390.77
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 50 μg Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Biotin ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μg Connectez-vous pour afficher 11 to 14 Days
$581.17
Détails
Humain Lapin HRP ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μg Connectez-vous pour afficher 11 to 14 Days
$581.17
Détails
Humain Lapin FITC ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μg Connectez-vous pour afficher 11 to 14 Days
$581.17
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Western Blot: DOC1 Antibody [NBP1-84064] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Western Blot: DOC1 Antibody [NBP1-84064] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Connectez-vous pour afficher 10 to 13 Days
$494.38
Détails

anti-Cyclin-Dependent Kinase 2 Associated Protein 1 Anticorps mieux référencés

  1. Human Polyclonal CDK2AP1 Primary Antibody pour IHC, IHC (p) - ABIN4305761 : Dieterich, Mellberg, Langenkamp, Zhang, Zieba, Salomäki, Teichert, Huang, Edqvist, Kraus, Augustin, Olofsson, Larsson, Söderberg, Molema, Pontén, Georgii-Hemming, Alafuzoff, Dimberg: Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. dans The Journal of pathology 2012 (PubMed)

Plus d’anticorps contre Cyclin-Dependent Kinase 2 Associated Protein 1 partenaires d’interaction

Mouse (Murine) Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) interaction partners

  1. Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor in uterus and is mainly localized to proliferating tissues.

  2. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

  3. (CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin.

  4. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12

  5. Results suggest that overexpression of CDK2-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2-/- mice.

  6. Cdk2ap1, a negative regulator of Cdk2 function and cell cycle, promotes Oct4 promoter methylation during murine embryonic stem cell differentiation to down-regulate Oct4 expression.

  7. Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.

  8. CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb.

Human Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) interaction partners

  1. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function.

  2. Knockdown of CDK2AP1 in hESCs results in increased p53 and enhances differentiation and favors it over a self-renewal fate.

  3. DOC1 re-expression in oral cancer cells causes a reversal of EMT. DOC1 promotes NURD binding to a subset of target loci.

  4. The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth.

  5. knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent

  6. In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein.

  7. Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis

  8. CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.

  9. Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma.

  10. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region

  11. exerts its effect on stem cell maintenance/differentiation through epigenetic regulation [review]

  12. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all oral lesions.

  13. P12(CDK2AP1) is downregulated by miR-21

  14. Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity.

  15. Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes.

  16. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.

  17. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

  18. CDK2AP1 is a novel multiple sclerosis susceptibility loci, and it's risk allele correlates with diminished RNA expression of the cell cycle regulator CDK2AP1

  19. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.

  20. DOC1 has a differential expression in microsatellite-unstable human colorectal neoplasms.

Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) profil antigène

Profil protéine

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with CDK2AP1

  • cyclin-dependent kinase 2 associated protein 1 S homeolog (cdk2ap1.S) anticorps
  • cyclin dependent kinase 2 associated protein 1 (CDK2AP1) anticorps
  • cyclin dependent kinase 2 associated protein 1 pseudogene (LOC475806) anticorps
  • cyclin-dependent kinase 2 associated protein 1 (cdk2ap1) anticorps
  • CDK2 (cyclin-dependent kinase 2)-associated protein 1 (Cdk2ap1) anticorps
  • cyclin-dependent kinase 2 associated protein 1 (Cdk2ap1) anticorps
  • cyclin dependent kinase 2 associated protein 1 (Cdk2ap1) anticorps
  • Apc10 anticorps
  • Cdkap1 anticorps
  • doc-1 anticorps
  • DOC1 anticorps
  • DORC1 anticorps
  • MGC64532 anticorps
  • p12 anticorps
  • p12DOC-1 anticorps
  • ST19 anticorps

Protein level used designations for CDK2AP1

cyclin-dependent kinase 2 associated protein 1 , CDK2-associated protein 1 , CDK2 (cyclin-dependent kinase 2)-associated protein 1 , cyclin-dependent kinase 2-associated protein 1 , CDK2-associated protein1 , deleted in oral cancer 1 , putative oral cancer suppressor , Deleted in oral cancer-1

GENE ID SPECIES
380551 Xenopus laevis
452342 Pan troglodytes
475806 Canis lupus familiaris
549484 Xenopus (Silurana) tropicalis
615387 Bos taurus
704412 Macaca mulatta
100153712 Sus scrofa
13445 Mus musculus
8099 Homo sapiens
360804 Rattus norvegicus
101825251 Mesocricetus auratus
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