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The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). De plus, nous expédions CRLF2 Anticorps (131) et CRLF2 Protéines (17) et beaucoup plus de produits pour cette protéine.
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Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA (Montrer CSF2RA Kits ELISA), CRLF2, and IL3RA (Montrer IL3RA Kits ELISA) gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings.
TSLP (Montrer TSLP Kits ELISA) expression on the basophil membrane of patients with severe asthma was not significantly different from healthy controls.
high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of acute lymphoblastic leukemia
this study shows that CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia
data suggest that this high frequency of genetic aberrations in the context of a high CRLF2 expression could contribute to the high risk of relapse in P2RY8/CRLF2- and IGH/CRLF2-positive acute lymphoblastic leukemia.
CRLF2 overexpression is associated with childhood B-cell acute lymphoblastic leukemia.
CRLF2 gene rearrangement is associated with acute lymphoblastic leukemia.
TSLPR levels were found to be significantly higher in asthmatic than in nonasthmatic children. TSLPR expression in non-allergic asthmatic and allergic asthmatic groups was found to be significantly higher than in non-allergic nonasthmatic group
In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis
CD4 (Montrer CD4 Kits ELISA)+ T cells from atopic dermatitis patients directly interacted with TSLP (Montrer TSLP Kits ELISA) to produce a higher amount of IL-4 (Montrer IL4 Kits ELISA) than those from normal subjects, and this action was attenuated with anti-TSLPR antibody
these results suggest that TSLP (Montrer TSLP Kits ELISA)-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection
A novel mouse xenograft model to study the role of TSLP (Montrer TSLP Kits ELISA)-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt (Montrer AKT1 Kits ELISA) signal pathway.
Activating thymic stromal lymphopoietin (Montrer TSLP Kits ELISA) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.
Suggest that Treg defects in ApoE (Montrer APOE Kits ELISA)(-/-) mice might partially be attributed to the disruption of TSLP (Montrer TSLP Kits ELISA)-TSLPR-LAP signaling in epithelial cells and dendritic cells.
The structure of the mouse TSLP (Montrer TSLP Kits ELISA)-mediated signaling complex reveals how TSLP (Montrer TSLP Kits ELISA) establishes extensive interfaces with its cognate receptor (TSLPR).
TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
A previously unrecognized role was found for TSLP (Montrer TSLP Kits ELISA)/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (Montrer CCL1 Kits ELISA) production.
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.
cytokine receptor-like factor 2
, P2RY8/CRLF2 fusion
, TSLP receptor
, cytokine receptor CRL2 precusor
, cytokine receptor-like 2
, thymic stromal lymphopoietin protein receptor
, thymic stromal lymphopoietin receptor
, thymic stromal-derived lymphopoietin receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1