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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. De plus, nous expédions DNA (Cytosine-5)-Methyltransferase 1 Kits (31) et DNA (Cytosine-5)-Methyltransferase 1 Protéines (10) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 550 products:
Human Monoclonal DNMT1 Primary Antibody pour ChIP, CyTOF - ABIN252481
Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. dans Genes & development 2001
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Human Monoclonal DNMT1 Primary Antibody pour ChIP, IP - ABIN2668504
Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. dans Molecular and cellular biology 2007
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Human Polyclonal DNMT1 Primary Antibody pour DB, ELISA - ABIN4369817
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. dans International journal of cancer. Journal international du cancer 2003
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Human Polyclonal DNMT1 Primary Antibody pour IHC (p), IHC - ABIN314281
Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. dans Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Polyclonal DNMT1 Primary Antibody pour WB - ABIN387879
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. dans Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody pour FACS, WB - ABIN387878
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. dans Cancer research 2003
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Human Polyclonal DNMT1 Primary Antibody pour IHC, IHC (p) - ABIN4305683
Lin, Haffner, Zhang, Lee, Brennen, Britton, Kachhap, Shim, Liu, Nelson, Yegnasubramanian, Carducci: Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. dans The Prostate 2011
Human Polyclonal DNMT1 Primary Antibody pour EIA - ABIN358462
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. dans International journal of cancer. Journal international du cancer 2008
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Human Polyclonal DNMT1 Primary Antibody pour EIA - ABIN358447
Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. dans Genetics 2008
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Human Polyclonal DNMT1 Primary Antibody pour IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. dans Oncotarget 2015
Dnmt1 stability requires UHRF1 (Montrer UHRF1 Anticorps) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (Montrer HELLS Anticorps) Is Essential for Maintaining Global DNA Methylation (Montrer HELLS Anticorps) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (Montrer CEBPA Anticorps) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (Montrer UHRF1 Anticorps) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (Montrer SUV39H1 Anticorps) and that, together, Dnmt1 and Suv39h1 (Montrer SUV39H1 Anticorps) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
DNMT3B (Montrer DNMT3B Anticorps) rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to recurrent spontaneous abortion
we demonstrated that the downregulation of CLDN6 (Montrer CLDN6 Anticorps) is regulated through promoter methylation by DNMT1, which depends on the SMAD2 (Montrer SMAD2 Anticorps) pathway, and that CLDN6 (Montrer CLDN6 Anticorps) is a key regulator in the SMAD2 (Montrer SMAD2 Anticorps)/DNMT1/CLDN6 (Montrer CLDN6 Anticorps) pathway to inhibit EMT (Montrer ITK Anticorps), migration and invasion of breast cancer cells
GNAO1 (Montrer GNAO1 Anticorps) transcription was inhibited by promoter hypermethylation, contributing to its low expression. It was further revealed that the silencing effect was regulated by methyltransferase 1 (DNMT1), and was further enhanced by transforming growth factor beta (TGF-beta).
These results demonstrate that targeting NFkappaB (Montrer NFKB1 Anticorps)/PDL1 (Montrer CD274 Anticorps)/STAT3 (Montrer STAT3 Anticorps)/DNMT1 axis is a new therapeutic strategy for preventing or overcoming the acquired resistance to sorafenib in hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps))patients
PPI decreased expression of DNMT1. Silenced HOTAIR reduced DNMT1 protein expression. Exogenously expressed HOTAIR resisted PPI-inhibited DNMT1 protein expression. Excessive EZH2 (Montrer EZH2 Anticorps) antagonized PPI-suppressed DNMT1 protein expression or vice versa. The interactions among HOTAIR, DNMT1 and EZH2 (Montrer EZH2 Anticorps), and reciprocal regulation of DNMT1 and EZH2 (Montrer EZH2 Anticorps) contribute to the overall responses of PPI.
Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95 (Montrer UHRF1 Anticorps)-Dnmt1 axis has been demonstrated for humans and mice.
DNMT1 is predictive of diffuse large B-cell lymphomas (DLBCLs) patients' survival, and suggest that DNMT1 could be a DLBCL therapeutic target due to its significant association with Ki-67 (Montrer MKI67 Anticorps).
This is the first demonstration that dysregulated KLF4 (Montrer KLF4 Anticorps) expression associates with poor differentiation of pancreatic cancer. Epigenetic activation of miR (Montrer MLXIP Anticorps)-152/DNMT1/KLF4 (Montrer KLF4 Anticorps) signaling pathway by dietary DIM causes differentiation and significant growth inhibition of pancreatic cancer cells, highlighting its translational implications for pancreatic and other cancers.
Investigations demonstrate that KLF5 (Montrer KLF5 Anticorps) genomic loci are hypermethylated at proximal exon 4 and suppression of DNA methyltransferase 1 (DNMT1) expression by ShRNAs or a methylation inhibitor 5-Aza-CdR (Montrer RUNX1T1 Anticorps) can recover KLF5 (Montrer KLF5 Anticorps) expression.
(i) ectopic expression of miR (Montrer MLXIP Anticorps)-148a induces programmed cell death and represses cell proliferation by targeting DNMT1; (ii) miR (Montrer MLXIP Anticorps)-148a gene is regulated by DNA methylation (Montrer HELLS Anticorps) and DNMT1 in prostate cancer. We conclude that miR (Montrer MLXIP Anticorps)-148a is silenced by DNA methylation (Montrer HELLS Anticorps) and ectopic expression of miR (Montrer MLXIP Anticorps)-148a suppresses DNMT1 expression and induced apoptotic genes expression in hormone-refractory prostate cancer cells.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (Montrer DNMT3A Anticorps), Hdac1 (Montrer HDAC1 Anticorps), Kdm3a (Montrer KDM3A Anticorps) and Uhrf1 (Montrer UHRF1 Anticorps) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (Montrer NLRP5 Anticorps) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (Montrer MYLIP Anticorps)-29b promoter, up-regulated miR (Montrer MYLIP Anticorps)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (Montrer MYLIP Anticorps)-152 reduced Global DNA methylation (Montrer HELLS Anticorps) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (Montrer AKT1 Anticorps) and Ppar gamma (Montrer PPARG Anticorps).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (Montrer ASCL2 Anticorps) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (Montrer MTA2 Anticorps), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
The findings reveal that MET1-mediated shoot regeneration is regulated by the cytokinin-induced cell cycle, and provide new insights into the regulation of DNA methylation (Montrer HELLS Anticorps) in shoot regeneration.
Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (Montrer TFPI Anticorps)-alleles
MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (Montrer VIM Anticorps) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (Montrer HELLS Anticorps) and histone modification status in collaboration with MET1
VIM (Montrer VIM Anticorps) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (Montrer HELLS Anticorps) pathway.
Genetic studies indicate that the Polycomb (Montrer CBX2 Anticorps) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits DNMT1-dependent endothelial cells DNA hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel.
Single-cell transcriptome analysis detected Dnmt1 expression in murine migratory GABAergic embryonic preoptic area (POA)-derived cells. Deletion of Dnmt1 in postmitotic immature cells of the POA caused defective migration and severely diminished adult cortical interneuron numbers. DNMT1 preserves the migratory shape in part through negative regulation of Pak6 (Montrer PAK6 Anticorps), which stimulates neuritogenesis postmigration.
The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1, DNMT3A (Montrer DNMT3A Anticorps), and DNMT3B (Montrer DNMT3B Anticorps) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.
DNMT1 ablation from kidney proximal tubules enhanced cisplatin-induced acute kidney injury in mice, suggesting a renoprotective role of DNA methylation (Montrer HELLS Anticorps).
We show that expression of Id-1 (Montrer IDH1 Anticorps), a negative regulator of myogenesis, is enhanced in Dnmt1-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 influences cellular identity and determines lineage fidelity.
this study shows that DNMT1 might directly repress p53 (Montrer TP53 Anticorps), at least in part, by binding to the p53 (Montrer TP53 Anticorps) promoter locus
Knockdown of DNMT3A (Montrer DNMT3A Anticorps) or DNMT1 protected neurons against mutant Htt (Montrer HTT Anticorps)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (Montrer HTT Anticorps)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (Montrer HELLS Anticorps)-mediated transcriptional repression.
Sp1 (Montrer SP1 Anticorps)/NFkappaB p65 (Montrer NFkBP65 Anticorps)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.
2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 (Montrer MPRIP Anticorps) promoter, inducing hypermethylation that reduces RIP3 (Montrer MPRIP Anticorps) protein and consequently impaired RIP3 (Montrer MPRIP Anticorps)-dependent necroptosis.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI