DNA (Cytosine-5-)-Methyltransferase 3 Like Protéines (TRDMT1)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNA (Cytosine-5-)-Methyltransferase 3 Like Anticorps (224) et DNA (Cytosine-5-)-Methyltransferase 3 Like Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
TRDMT1 54427 Q9CWR8
TRDMT1 29947 Q9UJW3
TRDMT1 309680 Q1LZ50
Comment commander chez anticorps-enligne
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top DNA (Cytosine-5-)-Methyltransferase 3 Like Protéines sur anticorps-enligne.fr

Showing 8 out of 12 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Escherichia coli (E. coli) Humain His tag 50 μg Connectez-vous pour afficher 13 to 16 Days
$492.31
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Insect cells (Sf9) Humain DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$504.90
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,175.33
Détails
Baculovirus infected Insect Cells Humain GST tag   5 μg Connectez-vous pour afficher 10 to 12 Days
$400.46
Détails

TRDMT1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , , , ,
, , ,
Rat (Rattus)

Plus protéines pour DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) partenaires d'interaction

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. The Sirt1 (Montrer SIRT1 Protéines) protein suppressed transcription of Dnmt3l.

  2. The Dnmt3l mutation greatly reduced DNA methylation (Montrer HELLS Protéines) levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 (Montrer PLD6 Protéines) mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation (Montrer HELLS Protéines), many showed increased expression at the RNA level.

  3. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming

  4. By interacting with TRIM28 (Montrer TRIM28 Protéines), DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.

  5. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a (Montrer DNMT3A Protéines) due to hepatitis B X-protein bound to their promoters.

  6. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells

  7. Study demonstrates that Dnmt3L interacts with the Polycomb (Montrer CBX2 Protéines) PRC2 complex in competition with the DNA methyltransferases Dnmt3a (Montrer DNMT3A Protéines) and Dnmt3b (Montrer DNMT3B Protéines) to maintain low methylation levels at the Histone 3 H3K27me3 regions.

  8. Data indicate that expression of Dnmt3a (Montrer DNMT3A Protéines), Dnmt3b (Montrer DNMT3B Protéines), Dnmt3L as well as maintenance Dnmt1o (Montrer DNMT1 Protéines) in oocytes and zygotes was not disrupted.

  9. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.

  10. The maternal store of Dnmt3L is not involved in embryonic de novo methylation.

Human DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. DNMT3L overexpression is associated with Down syndrome.

  2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.

  3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.

  4. crystal structures of DNMT3A (Montrer DNMT3A Protéines)-DNMT3L (autoinhibitory form) and DNMT3A (Montrer DNMT3A Protéines)-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively

  5. DNMT3L can address DNMT3A (Montrer DNMT3A Protéines)/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A (Montrer DNMT3A Protéines)/B

  6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX (Montrer VAC14 Protéines) response element

  7. DNMT3L is one of the key players in de novo DNA methylation (Montrer HELLS Protéines) of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  8. SNP rs2070565, as well as haplotypes AAA (Montrer APP Protéines) and GAA (Montrer GAA Protéines), may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans

  9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.

  10. mutation analysis of SYCP3 (Montrer SYCP3 Protéines), DNMT3L and MSH4 (Montrer MSH4 Protéines) in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

Profil protéine DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1)

Profil protéine

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRDMT1

  • DNA methyltransferase 3 like (DNMT3L)
  • DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l)
  • DNA methyltransferase 3 like (Dnmt3l)
  • D6Ertd14e Protéine
  • DNMT3L Protéine
  • ecat7 Protéine

Protein level used designations for TRDMT1

DNA (cytosine-5-)-methyltransferase 3-like , cytosine-5-methyltransferase 3-like protein , DNA (cytosine-5)-methyltransferase 3-like , human cytosine-5-methyltransferase 3-like protein

GENE ID SPECIES
100050680 Equus caballus
470099 Pan troglodytes
613785 Bos taurus
608536 Canis lupus familiaris
54427 Mus musculus
29947 Homo sapiens
309680 Rattus norvegicus
Fournisseurs de qualité sélectionnés pour DNA (Cytosine-5-)-Methyltransferase 3 Like Protéines (TRDMT1)
Avez-vous cherché autre chose?