DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Kits ELISA

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. De plus, nous expédions DNMT3A Anticorps (278) et DNMT3A Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
DNMT3A 1788 Q9Y6K1
Anti-Rat DNMT3A DNMT3A 444984 Q1LZ53
Anti-Souris DNMT3A DNMT3A 13435 O88508
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.061 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days

Plus Kits ELISA pour DNMT3A partenaires d'interaction

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. a feedback loop between miR (Montrer MLXIP Kits ELISA)-145 and DNMT3A is a potent signature for the Warburg effect in ovarian cancer, promising a potential target for improved anticancer treatment.

  2. In univariable analysis, patients carrying mutations in DNMT3A, U2AF1, and EZH2 (Montrer EZH2 Kits ELISA) had worse overall and relapse-free survival.

  3. Elastic Network Models, information theory, Protein Structure Network, and sequence evolution analysis were used to investigate intrinsic dynamics and allosteric properties of DNMT3A resolved in autoinhibitory and active states. The conformational transition between 2 states shows global motions. The dimer interface has a major role in defining the quaternary structure dynamics and establishing interdomain communication.

  4. HIF1A (Montrer HIF1A Kits ELISA)-AS2 (Montrer ARSA Kits ELISA) exerted the oncogenic functions in CRC (Montrer CALR Kits ELISA) through regulating miR (Montrer MLXIP Kits ELISA)-129-5p/DNMT3A axis.

  5. we found that DNMT3A was responsible for the down-regulation of miR (Montrer MLXIP Kits ELISA)-105 in gastric cancer cells

  6. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (Montrer INS Kits ELISA) resistance in vitro and in vivo.

  7. Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.

  8. 2.65-angstrom crystal structure of the DNMT3A-DNMT3L-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation and establishment of its aetiological link to human disease

  9. based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies

  10. The emodininduced downregulation of UHRF1 led to an increase in the level of DNA methyltransferase 3A.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (Montrer TP53 Kits ELISA) expression on the development of cloned embryos, and its interaction with HDAC1 (Montrer HDAC1 Kits ELISA) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (Montrer DNMT3B Kits ELISA) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. individual pain vulnerability may be inherent mostly in the emotional/affective component of chronic pain and remain consistent in different aspects of negative emotion, in which adaptive changes in the function of DNA methyltransferase 3a for DNA methylation in central amygdala may play an important role.

  2. Taken together, these data demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin (Montrer INS Kits ELISA) resistance in vitro and in vivo.

  3. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (Montrer DNMT1 Kits ELISA), DNMT3A, and DNMT3B (Montrer DNMT3B Kits ELISA) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  4. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (Montrer FRAP1 Kits ELISA) in Dnmt3aR878H/WT mice.

  5. Knockdown of DNMT3A or DNMT1 protected neurons against mutant Htt-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation-mediated transcriptional repression.

  6. Data demonstrate that DNMT3A and DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation.

  7. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (Montrer DPEP1 Kits ELISA)-mediated epigenetic silencing of the MOR (Montrer OPRM1 Kits ELISA) and KOR (Montrer OPRK1 Kits ELISA) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  8. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  9. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  10. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (Montrer DNMT3B Kits ELISA) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (Montrer PPARG Kits ELISA).

DNMT3A profil antigène

Antigen Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A) anticorps
  • DNA methyltransferase 3 alpha (dnmt3a) anticorps
  • DNA methyltransferase 3 alpha (Dnmt3a) anticorps
  • DNA methyltransferase 3A (Dnmt3a) anticorps
  • DNMT3A anticorps
  • DNMT3A2 anticorps
  • M.HsaIIIA anticorps
  • MmuIIIA anticorps

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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