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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. De plus, nous expédions DRAP1 Anticorps (43) et DRAP1 Kits (4) et beaucoup plus de produits pour cette protéine.
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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
, DR1-associated protein 1 (negative cofactor 2 alpha)
, dr1-associated protein 1
, negative co-factor 2-alpha
, negative cofactor 2 alpha