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Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils.
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Human Polyclonal beta Defensin 1 Primary Antibody pour IHC (p), ELISA - ABIN2473295
Goldman, Anderson, Stolzenberg, Kari, Zasloff, Wilson: Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. dans Cell 1997
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Human Polyclonal beta Defensin 1 Primary Antibody pour ELISA, WB - ABIN2473296
Kelly, Glover, Campbell, Kominsky, Ehrentraut, Bowers, Bayless, Saeedi, Colgan: Fundamental role for HIF-1? in constitutive expression of human ? defensin-1. dans Mucosal immunology 2013
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identification of critical promoter regions of DEFB1 that are epigenetically influenced by lactobacilli in vaginal keratinocytes
Endometrial tissues and epithelial cells constitutively secreted both BD-1 and -2 mostly at the apical compartment. Both genistein and daidzein induced BDs secretion which reached a peak at 5-15 min. The apical secretion of BDs was coincidence with increased Cl- secretion induced by genistein.
The polymorphisms in DEFB1 were not associated with hBD (Montrer HBd Anticorps) salivary level and caries experience (p > 0.05) in children.
These findings suggest a role for hBD-1 in psoriasis pathogenesis
Significant associations were found between periodontitis and g. -20G> A (rs11362) and g. -44C> G (rs1800972) SNPs in DEFB1 gene as well as p.Ala29Thr (rs1126477) and p.Lys47Arg (rs1126478) SNPs in LTF (Montrer LTF Anticorps) gene.
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
findings lead us to hypothesize an involvement of hBD-1 mediated innate immunity in the modulation of the susceptibility towards adeno (Montrer ADORA2A Anticorps)-tonsillar hypertrophy development.
Two DEFB1 SNPs were significantly associated with the DMFT(decayed, missing, filled teeth) index.
Multivariate logistic regression analysis showed that hBD-1 basal cell loss (>/=20% of prostatic glands in total cores) is an independent factor for predicting prostatic adenocarcinoma (odds ratio: 4.739, confidence interval: 1.093-20.554, p = 0.038). hBD-1 loss of basal cells is a useful indicator to identify extremely high-risk patients with initially negative biopsy.
It was concluded that bile acids can differentially regulate colonic epithelial beta-defensin expression and secretion; the authors discuss the implications for intestinal health and disease.-
Fenofibrate and gemfibrozil inhibit LPS (Montrer TLR4 Anticorps)-induced inflammatory activation of macrophages via PPARalpha (Montrer PPARA Anticorps)/beta-defensin 1/TLR4 (Montrer TLR4 Anticorps) pathway.
these studies demonstrate a role for the murine beta-defensin 1 peptide in early control of Candida infection in a murine model of mucosal candidiasis
Akt1 (Montrer AKT1 Anticorps) is involved in the regulation of defensin (Montrer DEF Anticorps) expression and the innate immune response important for bacterial clearance
Histopathology showed a greater inflammatory influx in the lungs of mBD-1((-/-)) mice at Day 3 postinfection compared with WT C57BL/6 mice
The decreased production of antimicrobial peptides by burn-site epidermal keratinocytes influenced by Gr-1 (Montrer GSR Anticorps)(+)CD11b (Montrer ITGAM Anticorps)(+) cells was shown to be restored by glycyrrhizin.
elimination of mBD-1 results in a defect in the ability of the host to clear H. influenzae from the lung, which is most consistent with this peptide functioning as an antibiotic at the airway surface.
The expression of BD1 was significantly elevated in the lungs of cigarette smoke-exposed mice compared with air-exposed mice.
Although both murine beta-defensin (mBD)-1 and mBD2 (Montrer MBD2 Anticorps) are constitutively expressed in normal BALB/c and C57BL/6 corneas, mBD-1 is not required for host resistance against Pseudomonas aeruginosa-induced corneal infection.
pBD1 showed low hemolytic activity and high thermal stability. These properties are relevant for the biotechnological applications of the peptide.
Zinc sulfate and L-isoleucine induce beta defensin expression in a porcine cell line.
Presence of beta-defensin 1 in the upper respiratory tract is associated with resistance against respiratory infection with Bordetella pertussis in older piglets
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
, beta-defensin 1
, Gal 1
, Gal 1-alpha
, antimicrobial peptide 1
, antimicrobial peptide CHP2
, chicken heterophil peptide 2
, gal-1 alpha
, gallinacin-1 alpha
, beta defensin-1 homolog
, prepro-beta-defensin 1
, Beta-defensin 1
, Defensin, beta 1
, DEFB1-like protein
, beta defensin 1