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DAZ4 is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF).
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study reported a new type of AZFc deletion (gr/gr (Montrer GSR Anticorps)-DAZ2 (Montrer DAZ2 Anticorps)-DAZ4-CDY1b (Montrer CDY2A Anticorps)) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population
Studies indicate that partial RNA-binding proteins DAZ1 (Montrer DAZ1 Anticorps)/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3 (Montrer DAZ3 Anticorps)/4 deletion was not associated with male infertility.
Oligospermia seems to be promoted by removing DAZ4 copy. Deletion of DAZ2 (Montrer DAZ2 Anticorps) and DAZ4 gene copies is associated with male infertility.
a common variant of the human Y chromosome lacks the DAZ3 (Montrer DAZ3 Anticorps)/DAZ4 and BPY2.2/BPY2.3 doublets in distal AZFc and thus these genes cannot be required for male fertility
All four DAZ genes are expressed in the human testis, and their products are highly polymorphic among men
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications\; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat\; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified\; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described.
deleted in azoospermia protein 4
, deleted in azoospermia 4