Deleted in Azoospermia-Like (DAZL) Kits ELISA

Human Deleted in Azoospermia-Like (DAZL) interaction partners

1. computational analysis of free energy change due to this point mutation using GROMOS96 indicated decreased stability of the DAZL protein. The N109T variant in an infertile male population may provide a genetic marker for mutational analysis of DAZL

2. Data suggest that DAZL may be one such factor in human female fertility

3. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.

4. hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility

5. data can be used to further elucidate the role of NANOS3 and DAZL in germ cell development both in vitro and in vivo

6. DAZL was not expressed either in normal cultures or lesions from cervixes with papillomavirus infections and cervical intraepithelial neoplasia.

7. analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility

8. Neither the A260G nor the A386G polymorphism of DAZL appeared to be involved in male infertility.

9. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

10. Abnormal DNA methylation of the DAZL promoter might represent an epigenetic marker of male infertility.

Zebrafish Deleted in Azoospermia-Like (DAZL) interaction partners

1. Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a (Montrer WNT8A Kits ELISA), grip2a, and Dazl, in the zebrafish embryo have been presented.

2. that DAZL specifically binds the HuB 3'UTR (Montrer UTS2R Kits ELISA) and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.

3. DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish

4. Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.

Cow (Bovine) Deleted in Azoospermia-Like (DAZL) interaction partners

1. analysis of genomic structure and transcript variants of the bovine DAZL gene

Xenopus laevis Deleted in Azoospermia-Like (DAZL) interaction partners

1. The dynamic intracellular localization suggests that Dazl is a multifunctional protein regulating RNA metabolism required for Xenopus germline development

2. Daz- and pumilio-like genes are asymmetrically localized in Pelophylax (Rana) oocytes and are expressed during early spermatogenesis.

3. Dazl has the ability to stimulate translation and function at the level of translation initiation.

Mouse (Murine) Deleted in Azoospermia-Like (DAZL) interaction partners

1. Down-regulated expression of Sox9 (Montrer SOX9 Kits ELISA) and Dazl may play important roles in MBP (Montrer MBP Kits ELISA)-induced testis injury.

2. DAZL and CPEB1 regulate mRNA translation during oocyte maturation.

3. findings demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state

4. Both yeast and mouse contain an RNA-binding protein, Rim4 and DAZL, respectively, that functions in translation and forms SDS (Montrer SDS Kits ELISA)-resistant aggregates during gametogenesis.

5. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 (Montrer REC8 Kits ELISA) induction and function

6. Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).

7. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl

8. Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign.

9. alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8.

10. DAZL was translocated to stress granules upon heat stress. Furthermore, stress granule assembly was significantly diminished in the early male germ cells of Dazl-knockout mice. DAZL induced the sequestration of signaling molecules such as RACK (Montrer GNB2L1 Kits ELISA).

Pig (Porcine) Deleted in Azoospermia-Like (DAZL) interaction partners

1. cloning & characterization of the Deleted in AZoospermia Like (pDAZL) gene; pDAZL gene might be a good candidate gene of litter size trait & provides some marker information for marker-assisted selection.

2. DNA methylation may suppress DAZL expression in somatic cells by interfering with Sp1 (Montrer SP1 Kits ELISA) binding.

3. The porcine DAZL coding sequence is highly homologous to those reported for the human and mouse cDNAs, and DAZL expression increases during oocyte maturation.

4. MK is able to maintain a proliferative PGC (Montrer PGC Kits ELISA) phenotype mediated by the suppression of DAZL in early germ cells

5. DAZL enhances in vitro derived porcine germ cell formation and meiosis.

6. DAZL c.570+385 A>G and DAZL c.735+150 C>A locus were the potential molecular markers for improving the sperm quality traits in pigs.