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The 3'-UTR-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development.
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Down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.
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DAZL and CPEB1 regulate mRNA translation during oocyte maturation.
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findings demonstrate that DAZL associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state
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Both yeast and mouse contain an RNA-binding protein, Rim4 and DAZL, respectively, that functions in translation and forms SDS-resistant aggregates during gametogenesis.
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Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function
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Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).
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demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl
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Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign.
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alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8.
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DAZL was translocated to stress granules upon heat stress. Furthermore, stress granule assembly was significantly diminished in the early male germ cells of Dazl-knockout mice. DAZL induced the sequestration of signaling molecules such as RACK.
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structures suggest that the number of DAZL molecules bound to GUU triplets in the 3'-UTR provides a method for modulating the translation of a target RNA
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If DAZL expression is reduced, then follicles can grow to the late follicular stage despite declining levels of circulating FSH, leading to more follicles ovulating and increased litter size.
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Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.
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CPEB1 regulates Dazl post-transcriptionally, and that DAZL is essential for meiotic maturation and embryonic cleavage
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Stra8 and Dazl are highly expressed in premeiotic germ cells that do not undergo further differentiation in aged mouse ovaries.
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Dazl contributes to the differentiation of embryonic stem cells into germ cells.
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Dazl is a master gene controlling germ cell differentiation and that ectopic expression of Dazl promotes the dynamic differentiation of mouse ES cells into gametes in vitro.
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Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity.
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Data show that EBs expressed Oct-4, OTR, OT, and DAZL.
