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anti-DTL Anticorps

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

45 Résultats:

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (C-Term) Primary Antibody

DTL Reactivité: Humain, Souris FACS, IF, IP, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2451940
$500.00
Plus shipping costs $45.00
100 μL
local_shipping Destination: Etats-Unis
Envoi sous 9 à 11 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reactivité: Humain, Souris EIA, FACS, WB Hôte: Lapin Polyclonal unconjugated
Pubmed 1
N° du produit ABIN951451
$539.00
Plus shipping costs $45.00
0.4 mL
local_shipping Destination: Etats-Unis
Envoi sous 6 à 8 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 1-730) Primary Antibody

DTL Reactivité: Humain IF, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN949333
$425.71
Plus shipping costs $45.00
100 μg
local_shipping Destination: Etats-Unis
Envoi sous 11 à 12 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reactivité: Humain, Souris FACS, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5538456
$570.63
Plus shipping costs $45.00
400 μL
local_shipping Destination: Etats-Unis
Envoi sous 2 à 3 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivité: Humain, Souris FACS, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2995947
$660.00
Plus shipping costs $45.00
400 μL (More quantities available)
local_shipping Destination: Etats-Unis
Envoi sous 11 à 16 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivité: Humain, Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN630978
$647.32
Plus shipping costs $45.00
50 μg
local_shipping Destination: Etats-Unis
Envoi sous 9 à 11 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (N-Term) Primary Antibody

DTL Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2782560
$389.00
Plus shipping costs $45.00
100 μL
local_shipping Destination: Etats-Unis
Envoi sous 2 à 3 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reactivité: Humain, Souris FACS, WB Hôte: Lapin Polyclonal RB24420 unconjugated
N° du produit ABIN654926
$412.50
Plus shipping costs $45.00
400 μL (More quantities available)
local_shipping Destination: Etats-Unis
Envoi sous 10 à 11 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 182-231) Primary Antibody

DTL Reactivité: Humain, Souris, Rat, Roussette (Chauve-souris), Boeuf (Vache), Chien, Cobaye, Cheval, Singe, Porc, Lapin WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6738232
$551.83
Plus shipping costs $45.00
100 μL
local_shipping Destination: Etats-Unis
Envoi sous 11 à 14 jours ouvrables

anti-DTL anticorps (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reactivité: Humain, Souris ELISA, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6390479
$367.82
Plus shipping costs $45.00
100 μL (More quantities available)
local_shipping Destination: Etats-Unis
Envoi sous 11 à 13 jours ouvrables
  • Type Primary
    • Primary
  • Target Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Histone 3 (H3)
    • Epidermal Growth Factor Receptor (EGFR)
    • Tumor Protein P53 (TP53)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • CD4 Molecule (CD4)
    • tau Protein
    • Tumor Necrosis Factor alpha (TNF)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Interferon gamma (IFNG)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Estrogen Receptor 1 (ESR1)
    • Nuclear Factor-KB P65 (NFkBP65)
    • Albumin (ALB)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • Myc Proto-Oncogene protein (MYC)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Integrin alpha M (ITGAM)
    • CD44
    • CD8
    • Histone H4
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • Jun Proto-Oncogene (JUN)
    • Interleukin 6 (IL6)
    • Vimentin (VIM)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Interleukin 2 Receptor, alpha (IL2RA)
    • CD5 Molecule (CD5)
    • Interleukin 2 (IL2)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Tuberous Sclerosis 1 (TSC1)
    • CD3
    • Synuclein, alpha (SNCA)
    • Glial Fibrillary Acidic Protein (GFAP)
    • Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1)
    • Androgen Receptor (AR)
    • CD14
    • Mucin 1, Cell Surface Associated (MUC1)
    • CD34
    • Cyclin-Dependent Kinase 1 (CDK1)
  • Application
    • Western Blotting (WB)
    • ELISA
    • Flow Cytometry (FACS)
    • Immunohistochemistry (IHC)
    • Immunofluorescence (IF)
    • Immunoprecipitation (IP)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Enzyme Immunoassay (EIA)
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Réactivité
    • Humain
    • Souris
    • Rat
    • Boeuf (Vache)
    • Chien
    • Cobaye
    • Cheval
    • Lapin
    • Roussette (Chauve-souris)
    • Singe
    • Porc
  • Cité dans publications
  • Images disponible
  • Hote
    • Lapin
    • Poulet
  • Clonalité
    • Polyclonal
  • Clone
    • RB24420
  • Epitope
    • AA 229-256
    • Center
    • Internal Region
    • AA 393-550
    • AA 1-730
    • C-Term
    • N-Term
    • AA 1-196
    • AA 182-231
    • AA 375-425
    • AA 680-730
    • Middle Region
  • Conjugué
    • Inconjugué
    • Biotin
    • FITC
    • HRP
    • APC
    • Alkaline Phosphatase (AP)
    • PE
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
  • Isotype
    • IgG
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized

DTL profil antigène

Profil protéine

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Gene names and symbols associated with DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) anticorps
  • denticleless E3 ubiquitin protein ligase (Dtl) anticorps
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) anticorps
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) anticorps
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) anticorps
  • 2810047L02Rik anticorps
  • 5730564G15Rik anticorps
  • cb151 anticorps
  • cdt2 anticorps
  • cdt2-a anticorps
  • chunp6871 anticorps
  • dcaf2 anticorps
  • l2dtl anticorps
  • ramp anticorps
  • RGD1310439 anticorps
  • wu:fb54b02 anticorps

Protein level used designations for DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPECIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio

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