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Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. De plus, nous expédions Diacylglycerol Kinase, beta 90kDa Anticorps (49) et et beaucoup plus de produits pour cette protéine.
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Memantine, an NMDA receptor antagonist, improves working memory deficits in Diacylglycerol kinase (DGK) beta knockout mice. These findings may support the hypothesis that DGKbeta has a pivotal role in cognitive function.
These findings suggest that DGKbeta regulates the spine formation at distal dendrites in medium spiny neurons
This study demonistrated that Dgkb distribuate in mice cerebellum
forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst.
that DGKbeta KO mice showed attention-deficit and hyperactive phenotype, similar to ADHD.
Results demonstrate that membrane-localized DGKbeta regulates spine formation by regulation of lipids, contributing to the maintenance of neural networks in synaptic transmission of cognitive processes including memory.
Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood.
in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta
findings further suggest that DGL-alpha and -beta may regulate neurite outgrowth by engaging temporally and spatially distinct molecular pathways
human diacylglycerol kinase beta gene can generate several enzyme isoforms, which can display different expression levels and subcellular localization but similar enzymatic activities in vitro.
Includes the identification and expression profile of this gene (named as KIAA0718).
Indicates that this protein can interact with keratin 31 and with protocadherin beta 5.
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.
diacylglycerol kinase, beta 90kDa
, diacylglycerol kinase beta
, diacylglycerol kinase, beta-like
, diacylglycerol kinase beta-like
, DAG kinase beta
, diglyceride kinase beta
, 90 kDa diacylglycerol kinase
, Diacylglycerol kinase 90kDa
, diacylglycerol kinase beta, 90kDa