Discs, Large Homolog 2 (Drosophila) Protéines (DLG2)

DLG2 encodes a member of the membrane-associated guanylate kinase (MAGUK) family. De plus, nous expédions DLG2 Anticorps (118) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
DLG2 1740 Q15700
DLG2 23859 Q91XM9
Rat DLG2 DLG2 64053 Q63622
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
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DLG2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Discs, Large Homolog 2 (Drosophila) (DLG2) partenaires d'interaction

Human Discs, Large Homolog 2 (Drosophila) (DLG2) interaction partners

  1. Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.

  2. DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia.

  3. The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95 (Montrer DLG4 Protéines), for example the GluD2 (Montrer GLUD2 Protéines) C-terminal Ile versus the Val found at the C-terminus of NMDA receptors.

  4. This study showed that DLG2 is related the complex learning.

  5. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 (Montrer DLG4 Protéines) PDZ1 shows that they are very similar in terms of amino-acid composition

  6. Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin (Montrer INS Protéines) sensitivity and beta-cell function.

  7. Coexpression of Kir2.1 (Montrer KCNJ2 Protéines) and PSD (Montrer PSD Protéines)-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 (Montrer KCNJ2 Protéines) clustering and suppression of channel internalization.

  8. identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma

Mouse (Murine) Discs, Large Homolog 2 (Drosophila) (DLG2) interaction partners

  1. This study demonstrated that in Chronic social defeat stress leads to changes PSD-93 in hippocampus of young mice.

  2. New DLG2 gene models for human and mouse. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.

  3. PSD-93 knockout led to downregulation of Cox-2 and iNOS (Montrer NOS2 Protéines) expression, and increase in the mRNA levels of IL-10 (Montrer IL10 Protéines) following ischemic brain injury.

  4. This study identified four proteins SynGAP (Montrer SYNGAP1 Protéines), Syntaxin-1A (Montrer STX1A Protéines), VDLC, and PKCbeta differentially expressed between PSD-93 KO and WT mice 4 h after tMCAO

  5. Downregulation of nAChR (Montrer CHRNA4 Protéines) subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (Montrer MPG Protéines) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.

  6. Membrane-associated guanylate kinase (Montrer GUK1 Protéines) homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.

  7. These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.

  8. Since NMDARs, Ca(2 (Montrer CA2 Protéines)+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.

  9. PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane (Montrer RYR1 Protéines).

  10. PSD-93 serves as a membrane-anchored substrate of Fyn (Montrer FYN Protéines) and plays a role in the regulation of Fyn (Montrer FYN Protéines)-mediated modification of NMDA receptor function

Profil protéine DLG2

Profil protéine

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.

Gene names and symbols associated with DLG2

  • discs, large homolog 2 (Drosophila) (dlg2)
  • discs large MAGUK scaffold protein 2 (DLG2)
  • discs, large homolog 2 (Drosophila) (Dlg2)
  • discs large MAGUK scaffold protein 2 (Dlg2)
  • A330103J02Rik Protéine
  • B230218P12Rik Protéine
  • B330007M19Rik Protéine
  • chapsyn-110 Protéine
  • Dlgh2 Protéine
  • Gm1197 Protéine
  • PPP1R58 Protéine
  • PSD-93 Protéine
  • PSD93 Protéine

Protein level used designations for DLG2

PSD-93 , disks large homolog 2 , postsynaptic density protein 93 , channel-associated protein of synapse-110 , channel-associated protein of synapses, 110kDa , discs, large homolog 2, chapsyn-110 , postsynaptic density protein PSD-93 , protein phosphatase 1, regulatory subunit 58 , chapsyn-110 , discs large homolog 2 , synaptic density protein PSD-93

GENE ID SPECIES
497638 Danio rerio
1740 Homo sapiens
23859 Mus musculus
64053 Rattus norvegicus
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