anti-Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) Anticorps

DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. De plus, nous expédions DVL3 Protéines (6) et et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
DVL3 13544 Q61062
DVL3 1857 Q92997
DVL3 303811  
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué IF, IHC (p), WB DVL3 Antibody (C-term)  western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the DVL3 antibody detected the DVL3 protein (arrow). DVL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DVL3 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Lapin Inconjugué WB Western blot analysis of Dishevelled 3 expression in HEK293T (A), Raw264.7 (B), rat kidney (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
Souris Lapin Inconjugué WB Western blot analysis of Dishevelled 3 using anti- Dishevelled 3 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat brain tissue lysates,   Lane 2: mouse brain tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- Dishevelled 3 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Dishevelled 3 at approximately 78KD. The expected band size for Dishevelled 3 is at 78KD. 100 μg Connectez-vous pour afficher 4 to 6 Days
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DVL3 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 2 to 3 Days
Humain Lapin Inconjugué ICC, IF, IHC (p), IHC, WB ICC/IF Image Dishevelled 3 antibody [N1N2], N-term detects Dishevelled 3 protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Dishevelled 3 protein stained by Dishevelled 3 antibody [N1N2], N-term , diluted at 1:500. Red: phalloidin, a cytoskeleton marker, stained by phalloidin (invitrogen, A12380) diluted at 1:200. Blue: Hoechst 33342 staining. WB Image Sample (30 ug of whole cell lysate) A: HCT116 7.5% SDS PAGE antibody diluted at 1:10000 100 μL Connectez-vous pour afficher 3 to 4 Days
Humain Lapin Inconjugué ELISA, IHC, IHC (p) 100 μL Connectez-vous pour afficher 11 to 14 Days
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, WB Western blot analysis of extracts from Jurkat cells, using DVL3 antibody.The lane on the left is treated with the antigen-specific peptide. ABIN6275519 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Connectez-vous pour afficher 11 to 12 Days
Humain Lapin Inconjugué EIA, IF, IHC (p), WB   0.4 mL Connectez-vous pour afficher 4 to 8 Days
Humain Lapin Inconjugué ICC, IF, IHC, IHC (p), WB Immunohistochemistry: Dishevelled-3 Antibody [NBP2-38846] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Western Blot: Dishevelled-3 Antibody [NBP2-38846] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: RT-4.Lane 3: U-251 MG 0.1 mL Connectez-vous pour afficher 10 to 13 Days

Plus d’anticorps contre DVL3 partenaires d’interaction

Xenopus laevis Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) interaction partners

  1. Different Dvl proteins (Dvl1, Dvl2, Dvl3) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt signaling in Xenopus gastrulation.

  2. Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.

Mouse (Murine) Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) interaction partners

  1. Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb

  2. Dvl3 is important for IPMK to access substrates and generate IP5, activating down-stream signaling.

  3. Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability.

  4. Dvl2 and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body.

  5. As embryos reach blastocyst stage, Dishevelled 2 becomes increasingly associated with cell membrane in trophectoderm cells, while at E4.5, Dishevelled 3 is highly enriched in the cytoplasm of inner cell mass cells.

  6. The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl.

  7. G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells

  8. Dvl1, Dvl2 and Dvl3 are functionally redundant in cardiac outflow tract, cochlea, and neural tube development.

Human Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) interaction partners

  1. downregulation of ASPM expression pronouncedly attenuated the proliferation, colony formation, and the invasive behavior of PCA cells, and dramatically reduced the number of ALDH(+) CSCs and inhibited cancer stemness and tumorigenicity. Mechanistically, ASPM interacts with disheveled-3 (Dvl-3), a cardinal upstream regulator of canonical Wnt signaling, and inhibits its proteasome-dependent degradation

  2. These findings expand the clinical spectrum of Robinow syndrome associated with DVL3 mutations. To date, comparison of clinical data of DVL3 mutation-positive individuals with those of patients with genetically different forms did not allow delineation of gene-specific phenotypes.

  3. Dvl3 is overexpressed in human HCCs. The NP-Dvl3 is the more stable and active form of the protein and enhances HCC stemness.

  4. we found that Wnt3a treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3. Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a treatment by stabilizing Dvl protein levels.

  5. Studied and identified candidate biomarkers of biochemical recurrence (BCR) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR. DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.

  6. two mutually exclusive functions of the DEP domain in Wnt signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.

  7. Genetic changes between MLH1 and MSH2 were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 and DVL3 genes (p = 0.034).

  8. Data show that dishevelled proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

  9. Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.

  10. DVL3 transcripts decreased in individuals with major depressive disorder

  11. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2.

  12. All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.

  13. data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway.

  14. findings confirm that p38 and PAX2 are important for the Dvl-3 induced upregulation of p120ctn

  15. Tumors that responded to IGFIR inhibition contain relatively lower levels of DVL3 protein than resistant tumors.

  16. data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5.

  17. High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.

  18. Study showed an association of DVL-1 and DVL-3 with Hirschsprung's disease.

  19. AMPK activators suppress cervical cancer cell growth by impairing DVL3 protein synthesis via AMPK/mTOR signaling and/or partially promoting the proteasomal degradation of DVL3

  20. A harmful p.Ser175Gly substitution & 3 benign variants (p.Ile353Val, p.Ile384Val, & p.Ala641Thr) were found in a cohort of patients with neural tube defects but not in controls.

Zebrafish Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) interaction partners

  1. Maternal transcripts for dvl2 and dvl3a are most abundantly expressed, whereas the transcript levels of other dvl genes are negligible. Dvl2 and Dvl3a products are required for the activation of zygotic Wnt/ss-catenin signaling and Wnt/planar cell polarity pathway, and regulate zygotic developmental processes in a dosage-dependent manner.

DVL3 profil antigène

Profil protéine

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.

Gene names and symbols associated with DVL3

  • dishevelled segment polarity protein 3 L homeolog (dvl3.L) anticorps
  • dishevelled segment polarity protein 3 (dvl3) anticorps
  • dishevelled segment polarity protein 3 (DVL3) anticorps
  • dishevelled segment polarity protein 3 (Dvl3) anticorps
  • dishevelled segment polarity protein 3a (dvl3a) anticorps
  • dsh3 anticorps
  • dvl3 anticorps
  • wu:fb75f04 anticorps
  • wu:fi22h02 anticorps
  • wu:fp61b09 anticorps

Protein level used designations for DVL3

DSH homolog 3 , Dishevelled-3 , dishevelled, dsh homolog 3 , dishevelled3 , segment polarity protein dishevelled homolog DVL-3 , dishevelled, dsh homolog 3 (Drosophila) , dishevelled-3 , dishevelled 3 (homologous to Drosophila dsh) , dishevelled 3, dsh homolog , dishevelled 3 , dishevelled, dsh homolog 3a

444527 Xenopus laevis
100144702 Xenopus (Silurana) tropicalis
460882 Pan troglodytes
100220188 Taeniopygia guttata
100583216 Nomascus leucogenys
13544 Mus musculus
1857 Homo sapiens
539203 Bos taurus
303811 Rattus norvegicus
424949 Gallus gallus
478650 Canis lupus familiaris
100621038 Sus scrofa
80972 Danio rerio
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