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DNAJC7 encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. De plus, nous expédions DNAJC7 Protéines (5) et beaucoup plus de produits pour cette protéine.
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The data from the current study for the first time demonstrated increased serum polyglutamylated DNAJC7 as a potential biomarker for renal cell carcinoma (Montrer MOK Anticorps) early detection
ubiquitin-proteasomal regulation of CCRP and HSP70 (Montrer HSP70 Anticorps) are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers
these findings strongly suggest that DnaJC7 participates in p53 (Montrer TP53 Anticorps)/MDM2 (Montrer MDM2 Anticorps) negative feedback regulatory pathway, and thereby enhancing the stability and activity of p53 (Montrer TP53 Anticorps).
TPR2 exhibited strong interaction with glucocorticoid receptor (Montrer NR3C1 Anticorps) and progesterone receptors.
TPR2 combines two TPR domains and a J domain to regulate the Hsp70 (Montrer HSP70 Anticorps)/Hsp90 chaperone (Montrer HSP90 Anticorps) system.
Data show that Tpr2 associates with Hsp90 (Montrer HSP90 Anticorps) and Hsp70 (Montrer HSP70 Anticorps) complexes, promoted the accumulation of Hsp70 (Montrer HSP70 Anticorps) in PR heterocomplexes in the presence of Hsp90 (Montrer HSP90 Anticorps). Thus, Tpr2 has the potential to regulate PR chaperoning.
In CCRP knockout (KO) mice CCRP regulates CAR at multiple steps in activation of the cytochrome 2b10 gene in liver: nuclear accumulation, RNA polymerase II recruitment and epigenetic modifications.
cytoplasmic constitutive active/androstane receptor retention protein mediates the retention of PXR (Montrer NR1I2 Anticorps) in the cytosol and modulates the activation of PXR (Montrer NR1I2 Anticorps) in response to Pregnenolone Carbonitrile treatment
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.
cytoplasmic CAR retention protein
, cytoplasmic constitutive active/androstane receptor retention protein
, dnaJ homolog subfamily C member 7
, DnaJ (Hsp40) homolog, subfamily C, member 7
, dnaJ homolog subfamily C member 7-like
, tetratricopeptide repeat protein 2
, TPR repeat protein 2
, tetratricopeptide repeat domain 2