EF-Hand Calcium Binding Domain 4B Protéines (EFCAB4B)

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. De plus, nous expédions EF-Hand Calcium Binding Domain 4B Anticorps (54) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
EFCAB4B 84766 Q9BSW2
EFCAB4B 381812 Q3UP38
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Top EF-Hand Calcium Binding Domain 4B Protéines sur anticorps-enligne.fr

Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$547.80
Détails

EFCAB4B Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour EF-Hand Calcium Binding Domain 4B (EFCAB4B) partenaires d'interaction

Human EF-Hand Calcium Binding Domain 4B (EFCAB4B) interaction partners

  1. Results show the characterization of CRACR2A protein which encodes a large Rab GTPase (Montrer RAB6A Protéines) containing multiple functional domains contrary to small Rab (Montrer HRB Protéines) GTPases. It was found to play an unexpected role in regulating intracellular signaling pathways important for T cell activation.

  2. GTP binding (Montrer RND2 Protéines) and prenylation of CRACR2A were associated with its localization near the Golgi and its stability

  3. endothelial cells contain a long variant of CRACR2A which is an EF-hand-containing Rab (Montrer HRB Protéines) protein that lacks impact on CRAC channels

  4. CRACR2A interacts directly with Orai1 and STIM1 (Montrer STIM1 Protéines), forming a ternary complex that dissociates at elevated Ca(2 (Montrer CA2 Protéines)+) concentrations; is a key regulator of CRAC channel-mediated SOCE

Mouse (Murine) EF-Hand Calcium Binding Domain 4B (EFCAB4B) interaction partners

  1. GTP binding (Montrer RND2 Protéines) and prenylation of CRACR2A (Montrer EFCAB4A Protéines) were associated with its localization near the Golgi and its stability

Profil protéine EF-Hand Calcium Binding Domain 4B (EFCAB4B)

Profil protéine

Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).

Gene names and symbols associated with EFCAB4B

  • calcium release activated channel regulator 2A (CRACR2A)
  • calcium release activated channel regulator 2A (Cracr2a)
  • CRACR2A Protéine
  • Gm462 Protéine
  • Gm1073 Protéine

Protein level used designations for EFCAB4B

CRAC channel regulator 2A , EF-hand calcium-binding domain-containing protein 4B , calcium release-activated calcium channel regulator 2A

GENE ID SPECIES
84766 Homo sapiens
381812 Mus musculus
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