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Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (n-6 and n-3 C18-, C20- and C22-PUFA). De plus, nous expédions ELOVL2 Anticorps (51) et et beaucoup plus de produits pour cette protéine.
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Network-based analysis suggests a role for Elovl2 in glucose-induced insulin secretion. Elovl2 silencing decreased glucose-stimulated insulin secretion in mouse and human beta cell lines.
The proportion of DHA in the liver and serum of the Elovl2(-/-) offspring was significantly lower than in the Elovl2(+/+) offspring. Remarkably, the DHA level in the Elovl2(+/-) offspring nursed by DHA-free-fed Elovl2(-/-) mothers was almost as high as in +/+ pups delivered by +/+ mothers, suggesting that endogenous synthesis in the offspring can compensate for maternal DHA deficiency.
Liver docosahexanoic acid synthesis (via ELOVL2), in addition to controlling de novo lipogenesis, also regulates lipid storage and fat mass expansion in an SREBP-1c-independent fashion.
heterozygous Elovl2(+/-) male mice exhibited haploinsufficiency, with reduced levels of C28:5 and C30:5n-6 PUFAs, which gave rise to impaired formation and function of haploid spermatides.
ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.
Results shows that ELOVL2 promoter displays an exceptionally consistent increase in DNA methylation with age in all tissues.
ELOVL2 methylation is a marker of cell divisions occurring during human aging
common variations not associated with polyunsaturated fatty acid levels in breast milk
Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERalpha in Breast Cancer Cells
Polymorphisms in the ELOVL2 gene were not associated with the risk of developing allergic disease
results show that the ELOVL2 locus provides a very good source of information about human chronological age based on analysis of blood, including bloodstains, and it may constitute a powerful and reliable predictor in future forensic age estimation models
we do not found the association between rs3756593 of ELOVL2 gene and acute coronary syndrome in Chinese Han population
Methylation of ELOVL2 gene is a new epigenetic marker of age.
rs3756963 in ELOVL2 gene may be associated with paranoid schizophrenia.
gene interaction analysis showed that the combined genotype of FADS1 rs174556 (T/T) and ELOVL2 rs3756963 (T/T) was weakly associated with coronary artery disease
Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (n-6 and n-3 C18-, C20- and C22-PUFA). Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility.
3-keto acyl-CoA synthase Elovl2
, ELOVL FA elongase 2
, ELOVL fatty acid elongase 2
, elongation of very long chain fatty acids protein 2
, sequence similarity to Cig30 2
, very-long-chain 3-oxoacyl-CoA synthase 2
, 3-keto acyl-CoA synthase ELOVL2
, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
, elongation of very long chain fatty acids-like 2