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ESX1 encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. De plus, nous expédions et et beaucoup plus de produits pour cette protéine.
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ESX1 mRNA level decreases as the severity of spermatogenic defects increase in non-obstructive azoospermic men.
ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men
proteolytic processing of ESXR1 plays a role in concerted regulation of the cell cycle and transcription in human cells
ESX1L is expressed during all stages of placental development and is localized to sparse areas of trophoblast in terminal villi in association with cytotrophoblastic cells
In FGR-affected placentae, ESX1L levels were lower than in gestation-matched controls, indicating a potential role for the ESX1L gene within the growth control mechanism of the fetus, through its effect on placental function.
Use of wild-type and ESX-1-deficient mycobacterial strains demonstrates that mycobacterial type 7 secretion system (T7SS) differentially affects macrophage cell death and interleukin (IL)-1b secretion.
ESX1 existed in the testes after 3 weeks of age, coincident with the appearance of round spermatids.ESX1 expression became more abundant in the seminiferous tubules as the development of round spermatids progressed into spermatozoa.
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis.
, extraembryonic, spermatogenesis, homeobox 1 homolog
, homeobox protein ESX1
, extraembryonic spermatogenesis homeobox 1