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Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.. De plus, nous expédions EBF1 Protéines (4) et et beaucoup plus de produits pour cette protéine.
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Human Monoclonal EBF1 Primary Antibody pour ELISA, WB - ABIN560684
Seifert, Sellmann, Bloehdorn, Wein, Stilgenbauer, Dürig, Küppers: Cellular origin and pathophysiology of chronic lymphocytic leukemia. dans The Journal of experimental medicine 2012
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Human Polyclonal EBF1 Primary Antibody pour ELISA, WB - ABIN451729
Lagergren, Månsson, Zetterblad, Smith, Basta, Bryder, Akerblad, Sigvardsson: The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells. dans The Journal of biological chemistry 2007
Human Polyclonal EBF1 Primary Antibody pour WB - ABIN515135
Lee, Xiao, Muench, Xiao, Fomin, Wiencke, Zheng, Dou, de Smith, Chokkalingam, Buffler, Ma, Wiemels: A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. dans Nucleic acids research 2012
Human Monoclonal EBF1 Primary Antibody pour RNAi, ELISA - ABIN560685
Zhang, Peng, Hu, Li, Sheng, Chen, Sullivan, Cerny, Hutchinson, Higgins, Miron, Zhang, Brehm, Li, Green, Li: The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. dans Nature genetics 2012
EBF1 heterozygosity resulted in the deregulation of at least eight transcription factors involved in lymphopoiesis and the deregulation of key proteins playing crucial roles in survival, development, and differentiation of pro-B lymphocytes.
Down-regulation of EBF1 (and EBF2 (Montrer EBF2 Anticorps)) genes leads to a severe impairment of myelin formation in Schwann cells.
The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin.
the interaction of the CCR4 (Montrer CCR4 Anticorps)-NOT complex with EBF1 diversifies the function of EBF1 in a context-dependent manner and may coordinate transcriptional and post-transcriptional gene regulation.
Pax5 (Montrer PAX5 Anticorps) and Ebf1 collaborate to modulate the transcriptional response to Notch (Montrer NOTCH1 Anticorps) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.
a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 and Pax5 (Montrer PAX5 Anticorps) genes, revealing a synergistic effect of combined dose reduction of these proteins
EBF1 is an important regulator of adipose morphology and fat cell lipolysis and may constitute a link between White adipose tissue inflammation, altered lipid metabolism, adipose hypertrophy, and insulin (Montrer INS Anticorps) resistance.
Ebf1 has a significant and novel role in glomerular development, podocyte maturation, and the maintenance of kidney integrity and function.
Our results suggest that Bach2 (Montrer BACH2 Anticorps) functions with Bach1 (Montrer BACH1 Anticorps) and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells
EBF1 functions as a key integrator of signal transduction, inflammation, and metabolism
EBF1 was down-regulated in cholangiocarcinoma (CCA (Montrer FBN2 Anticorps)) tissues and cell lines.
Data show that GS Homeobox 2 (Gsx2 (Montrer GSX2 Anticorps)) and Early B-cell factor 1 (Ebf1) combined overexpression in human embryonic stem (hES (Montrer RRBP1 Anticorps)) cells achieves high yields of medium spiny neurons (MSNs).
this study demonstrates a role for the AHR (Montrer AHR Anticorps) in regulating human B cell development, and it suggests that transcriptional alterations of EBF1 by the AHR (Montrer AHR Anticorps) are involved in the underlying mechanism
In a Chinese population the TT genotype and T alleles in rs36071027 in the EBF1 gene are associated with an increased risk of coronary artery disease and its severity.
A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE (Montrer APOE Anticorps), MINIPP1, FOXO3 (Montrer FOXO3 Anticorps), EBF1, CAMKIV (Montrer CAMK4 Anticorps), and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002).
In this genomewide association study, we found that variants at the EBF1, EEFSEC (Montrer EEFSEC Anticorps), AGTR2 (Montrer AGTR2 Anticorps), WNT4 (Montrer WNT4 Anticorps), ADCY5 (Montrer ADCY5 Anticorps), and RAP2C (Montrer RAP2C Anticorps) loci were associated with gestational duration and variants at the EBF1, EEFSEC (Montrer EEFSEC Anticorps), and AGTR2 (Montrer AGTR2 Anticorps) loci with preterm birth.
EBF1 polymorphism is associated with metabolic diseases.
Among 15 childhood ALL patients with EBF1-PDGFRB (Montrer PDGFRB Anticorps) fusion proteins, the fusion arose from interstitial deletion of 5q33 (n = 11), balanced rearrangement (n = 2), or complex rearrangement (n = 2).
EBF1 is critical for transcriptional control of SLAMF1 (Montrer SLAMF1 Anticorps) gene in human B cells.
two multi-zinc finger transcription cofactors named ZNF423 (Montrer 104125 Anticorps) and ZNF521 (Montrer ZNF521 Anticorps) have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias
Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
early B-cell factor 1
, transcription factor COE1-like
, transcription factor COE1
, Collier, Olf and EBF transcription factor 1
, olfactory neuronal transcription factor 1
, early B-cell factor (olfactory neuronal transcription factor 1)
, olfactory neuronal transcription factor
, early B-cell factor 1 protein