Ectonucleoside Triphosphate diphosphohydrolase 2 Protéines (ENTPD2)

The protein encoded by ENTPD2 is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). De plus, nous expédions ENTPD2 Anticorps (68) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ENTPD2 954 Q9Y5L3
ENTPD2 12496 O55026
ENTPD2 64467 O35795
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Showing 8 out of 10 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Baculovirus infected Insect Cells Humain His tag 10 μg Connectez-vous pour afficher 14 to 16 Days
$250.80
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$331.20
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,223.00
Détails
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,232.17
Détails
Human Cells Souris His tag   10 μg Connectez-vous pour afficher 4 Days
$234.03
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Human Cells Souris His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$325.00
Détails

ENTPD2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Plus protéines pour Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2) partenaires d'interaction

Human Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2) interaction partners

  1. In oviducts, remarkably, ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2), with the ability to hydrolyze ATP to AMP (Montrer APRT Protéines), are expressed in ciliated epithelial cells but with different subcellular localization.

  2. Hypoxia upregulates ENTPD2 through HIF-1alpha (Montrer HIF1A Protéines) in hepatocellular carcinoma and subsequently leading to the accumulation of extracellular 5'-AMP (Montrer APRT Protéines), which maintains myeloid-derived suppressor cells undifferentiated.

  3. NTPDase2 and -3 are ecto (Montrer TRIM33 Protéines)-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut (Montrer GUSB Protéines) inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease.

  4. the lack of ecto (Montrer TRIM33 Protéines)-nucleotidase activity exhibited by NTPDase2 beta and -2 gamma and the C399S mutant, as well as the large reduction of activity in the N443D mutant are due to alterations in the folding/maturation of these proteins

  5. NTPDase2 preferentially hydrolyzes nucleoside triphosphates.

  6. NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation

  7. Mutagenesis study indicate the importance of K62 located in CR1, K182 downstream of ACR3, and R155. Mutation of Asp (Montrer ASIP Protéines) at the six potential glycosylation sites showed the importance of N64 in CR1 and N443 in ACR5 in protein function and expression

  8. The role of cysteine 26 in the catalytic activity of NTPDase-2 and as the target of p-chloromercuriphenylsulfonate (pCMPS), a sulfhydryl reagent and NTPDase-2 inhibitor, is reported.

Mouse (Murine) Ectonucleoside Triphosphate diphosphohydrolase 2 (ENTPD2) interaction partners

  1. NTPDase2 and -3 are ecto (Montrer TRIM33 Protéines)-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut (Montrer GUSB Protéines) inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease.

  2. Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor (Montrer P2RY1 Protéines) signaling.

  3. The analysis of single and double KO mice demonstrated that NTPDase2 and P2Y1 (Montrer P2RY1 Protéines) receptors are not required for murine eye formation

  4. Authors propose that NTPDase2 has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation.

  5. Data indicate the absence of NTPDase2 and ATPase enzyme activity in taste buds of knockout mice, and suggest that NTPDase2 is the dominant form in taste buds.

  6. The medial habenula contains a specific perineuronal nonstellate subtype of astrocyte that expresses NTPDase2, strategically positioned to modulate purinergic transmission.

  7. Our results identify the ecto (Montrer TRIM33 Protéines)-nucleotidase NTPDase2 and functional P2X receptors at hippocampal progenitor cells

  8. In the mouse retina, NTPDase2 was chiefly localized in Muller glia and ganglion cell processes.

Profil protéine ENTPD2

Profil protéine

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with ENTPD2

  • ectonucleoside triphosphate diphosphohydrolase 2 (entpd2)
  • ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2)
  • Ectonucleoside triphosphate diphosphohydrolase 2 (enp2)
  • ectonucleoside triphosphate diphosphohydrolase 2 (Entpd2)
  • Cd39l1 Protéine
  • MGC76207 Protéine
  • MGC151796 Protéine
  • NTPDase-2 Protéine
  • NTPDase2 Protéine

Protein level used designations for ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2 , Ectonucleoside triphosphate diphosphohydrolase 2 , CD39 antigen-like 1 , NTPDase 2 , ecto-ATP diphosphohydrolase 2 , ecto-ATPDase 2 , ecto-ATPase 2 , testicular ecto-ATPase , cell membrane ecto-ATPase

GENE ID SPECIES
407961 Xenopus (Silurana) tropicalis
464883 Pan troglodytes
491241 Canis lupus familiaris
100196606 Salmo salar
100227326 Taeniopygia guttata
721617 Macaca mulatta
100126045 Bos taurus
100412544 Callithrix jacchus
954 Homo sapiens
12496 Mus musculus
64467 Rattus norvegicus
395797 Gallus gallus
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