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The protein encoded by ENTPD2 is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). De plus, nous expédions ENTPD2 Anticorps (62) et beaucoup plus de produits pour cette protéine.
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Hypoxia upregulates ENTPD2 through HIF-1alpha (Montrer HIF1A Protéines) in hepatocellular carcinoma and subsequently leading to the accumulation of extracellular 5'-AMP (Montrer APRT Protéines), which maintains myeloid-derived suppressor cells undifferentiated.
NTPDase2 and -3 are ecto (Montrer TRIM33 Protéines)-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut (Montrer GUSB Protéines) inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease.
the lack of ecto (Montrer TRIM33 Protéines)-nucleotidase activity exhibited by NTPDase2 beta and -2 gamma and the C399S mutant, as well as the large reduction of activity in the N443D mutant are due to alterations in the folding/maturation of these proteins
NTPDase2 preferentially hydrolyzes nucleoside triphosphates.
NTPDase2 has a role in portal fibroblast regulation of bile duct epithelium proliferation
Mutagenesis study indicate the importance of K62 located in CR1, K182 downstream of ACR3, and R155. Mutation of Asp (Montrer ASIP Protéines) at the six potential glycosylation sites showed the importance of N64 in CR1 and N443 in ACR5 in protein function and expression
The role of cysteine 26 in the catalytic activity of NTPDase-2 and as the target of p-chloromercuriphenylsulfonate (pCMPS), a sulfhydryl reagent and NTPDase-2 inhibitor, is reported.
Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor (Montrer P2RY1 Protéines) signaling.
The analysis of single and double KO mice demonstrated that NTPDase2 and P2Y1 (Montrer P2RY1 Protéines) receptors are not required for murine eye formation
Authors propose that NTPDase2 has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation.
Data indicate the absence of NTPDase2 and ATPase enzyme activity in taste buds of knockout mice, and suggest that NTPDase2 is the dominant form in taste buds.
The medial habenula contains a specific perineuronal nonstellate subtype of astrocyte that expresses NTPDase2, strategically positioned to modulate purinergic transmission.
Our results identify the ecto (Montrer TRIM33 Protéines)-nucleotidase NTPDase2 and functional P2X receptors at hippocampal progenitor cells
In the mouse retina, NTPDase2 was chiefly localized in Muller glia and ganglion cell processes.
The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants.
ectonucleoside triphosphate diphosphohydrolase 2
, Ectonucleoside triphosphate diphosphohydrolase 2
, CD39 antigen-like 1
, NTPDase 2
, ecto-ATP diphosphohydrolase 2
, ecto-ATPDase 2
, ecto-ATPase 2
, testicular ecto-ATPase
, cell membrane ecto-ATPase