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The protein encoded by ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases.
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ENTPD5 is a mediator of mutant p53 (Montrer TP53 Protéines) gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models
Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 (Montrer CASP3 Protéines) pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism
Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme.
The elevation of ENTPD5 activity therefore protects AKT (Montrer AKT1 Protéines)-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human (Montrer AKT1 Protéines)tumor samples with active AKT.
deregulation and loss of expression in the progression of laryngeal neoplasia [PCPH]
Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors.
PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta (Montrer PKCd Protéines)-dependent mechanism
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (Montrer NFE2L2 Protéines) regulation: cytochrome CYP2A5, GSTM3 (Montrer GSTM3 Protéines), GSTM1 (Montrer GSTM1 Protéines), ENTPD5,UDPGDH (Montrer UGDH Protéines), and EPHX1 (Montrer EPHX1 Protéines).
During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT (Montrer AKT1 Protéines) activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT (Montrer AKT1 Protéines) activation.
The effect of Entpd5 deletion on the development of hepatocellualr neoplasia in mice is reported.
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.
ectonucleoside triphosphate diphosphohydrolase 5
, ecto-nucleosidase triphosphate diphosphohydrolase 5
, CD39 antigen-like 4
, CD39-like 4
, GDPase ENTPD5
, NTPDase 5
, Pcph proto-oncogene protein
, UDPase ENTPD5
, guanosine-diphosphatase ENTPD5
, nucleoside diphosphatase
, proto-oncogene CPH
, uridine-diphosphatase ENTPD5
, Guanosine-diphosphatase ENTPD5
, Nucleoside diphosphatase
, Proto-oncogene cph
, Uridine-diphosphatase ENTPD5
, cph oncogene product
, cph proto-oncogene product