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The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. De plus, nous expédions ENPP2 Kits (32) et ENPP2 Protéines (14) et beaucoup plus de produits pour cette protéine.
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LPAR mRNA and ATX protein levels are anatomic site-dependent in high-grade serous carcinoma and the former are informative of disease outcome.
Study revealed that serum total ATX and ATX isoforms were significantly associated with the clinical stages of female subjects with melanoma.
Serum ATX levels may at least partially reflect histological severity in non-alcoholic fatty liver disease.
ATX-LPA (Montrer APOA Anticorps) axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK (Montrer MAPK1 Anticorps) signaling pathway.
Significant suppression of these aforementioned changes was observed after ATX/LPA (Montrer APOA Anticorps)-receptor/ROCK inhibition as well as suppression of fibrotic changes and MLC and cofilin (Montrer CFL1 Anticorps) phosphorylation in HTM cells.
Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels.
Results demonstrated, for the first time, that increased serum ATX activity and protein levels are associated with several aspects of quality of life in cholestatic patients as well as with markers of cholestatic liver injury and higher risks of death and transplantation. The study provides novel clinical evidence of the pruritogenic role of the ATX/lysophosphatidic acid axis in the pathogenesis of cholestatic itch.
ENPP2 silencing increased HBV replication approximately 2.3-fold by enhancing, via the type I IFN signaling pathway, HBV cccDNA (covalently closed circular DNA) translation into viral RNA.
This study demonstrated that Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes.
Structural and functional studies have revealed what makes ATX a unique lysoPLD, and how secreted ATX binds to its target cells. The ATX catalytic domain shows a characteristic bimetallic active site followed by a shallow binding groove that can accommodate nucleotides as well as the glycerol moiety of lysophospholipids, and by a deep lipid-binding pocket.
Data show that autotaxin (ATX)-mediated autocrine lipid signaling promotes naive pluripotency by intersecting with LIF (Montrer LIF Anticorps) and BMP4 (Montrer BMP4 Anticorps) signaling.
ENPP2 links Activin-A (Montrer INHBA Anticorps) enhanced mTOR (Montrer FRAP1 Anticorps) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.
Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.
These results indicate that ATX-lysophosphatidic acid-LPA3 (Montrer LPAR3 Anticorps) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (Montrer HBEGF Anticorps) and COX-2 (Montrer COX2 Anticorps) pathways.
ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (Montrer CYP11A1 Anticorps)) and enables 2 major mediators of SSc (Montrer CYP11A1 Anticorps) fibrogenesis, lysophosphatidic acid and IL-6 (Montrer IL6 Anticorps), to amplify the production of each other.
These results suggest that the post-transcriptional regulation of ATX expression by HuR (Montrer ELAVL1 Anticorps) and AUF1 (Montrer HNRNPD Anticorps) modulates cancer cell migration.
inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.
findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation
Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.
These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.
Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.
this study demonstrates an essential role of enpp2/lysophosphatidic acid signalling during early embryogenesis.
Autotaxin-Lysophosphatidic Acid axis acts downstream of Apoprotein (Montrer APOE Anticorps) B lipoproteins in endothelial cells.
When autotaxin (Atx), was overexpressed in zebrafish embryos by injecting atx mRNA, the embryos showed cardia bifida, a phenotype induced by down-regulation of sphingosine-1-phosphate signaling.
the ATX-LPA (Montrer LPA Anticorps)-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates
This study demonstrate that the zebrafish ortholog to mammalian atx displays evolutionarily conserved expression pattern characteristics.
results suggest a major role for the Atx/Lpar3 (Montrer LPAR3 Anticorps) signaling axis in regulating KV formation, ciliogenesis and L-R asymmetry via a Wnt (Montrer WNT2 Anticorps)-dependent pathway
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2
, extracellular lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2
, plasma lysophospholipase D
, phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)
, ectonucleotide pyrophosphatase/phosphodiesterase 2
, ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein
, ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog