anti-Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Anticorps

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. Results demonstrated, for the first time, that increased serum ATX activity and protein levels are associated with several aspects of quality of life in cholestatic patients as well as with markers of cholestatic liver injury and higher risks of death and transplantation. The study provides novel clinical evidence of the pruritogenic role of the ATX/lysophosphatidic acid axis in the pathogenesis of cholestatic itch.

2. ENPP2 silencing increased HBV replication approximately 2.3-fold by enhancing, via the type I IFN signaling pathway, HBV cccDNA (covalently closed circular DNA) translation into viral RNA.

3. This study demonstrated that Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer's Disease Outcomes.

4. Structural and functional studies have revealed what makes ATX a unique lysoPLD, and how secreted ATX binds to its target cells. The ATX catalytic domain shows a characteristic bimetallic active site followed by a shallow binding groove that can accommodate nucleotides as well as the glycerol moiety of lysophospholipids, and by a deep lipid-binding pocket.

5. We conclude that an ATM-ATX axis interconnects double-strand breaks with silica-induced inflammation and propagates these effects in epithelial cells

6. we present a new crystal structure of ATX in complex with orthovanadate (ATX-VO5), which binds the Ogamma nucleophile of Thr209 and adopts a trigonal bipyramidal conformation, following the nucleophile attack onto the substrate.We propose that ATX follows the associative two-step in-line displacement mechanism.

7. The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed.

8. These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.

9. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels

10. AKT (Montrer AKT1 Anticorps) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (Montrer NFATC3 Anticorps)-mediated p23 (Sec24C (Montrer SEC24C Anticorps)) expression

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. Data show that autotaxin (ATX)-mediated autocrine lipid signaling promotes naive pluripotency by intersecting with LIF (Montrer LIF Anticorps) and BMP4 (Montrer BMP4 Anticorps) signaling.

2. ENPP2 links Activin-A (Montrer INHBA Anticorps) enhanced mTOR (Montrer FRAP1 Anticorps) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

3. This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.

4. Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.

5. These results indicate that ATX-lysophosphatidic acid-LPA3 (Montrer LPAR3 Anticorps) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (Montrer HBEGF Anticorps) and COX-2 (Montrer COX2 Anticorps) pathways.

6. ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (Montrer CYP11A1 Anticorps)) and enables 2 major mediators of SSc (Montrer CYP11A1 Anticorps) fibrogenesis, lysophosphatidic acid and IL-6 (Montrer IL6 Anticorps), to amplify the production of each other.

7. These results suggest that the post-transcriptional regulation of ATX expression by HuR (Montrer ELAVL1 Anticorps) and AUF1 (Montrer HNRNPD Anticorps) modulates cancer cell migration.

8. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

9. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

10. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Zebrafish Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) interaction partners

1. this study demonstrates an essential role of enpp2/lysophosphatidic acid signalling during early embryogenesis.

2. Autotaxin-Lysophosphatidic Acid axis acts downstream of Apoprotein (Montrer APOE Anticorps) B lipoproteins in endothelial cells.

3. When autotaxin (Atx), was overexpressed in zebrafish embryos by injecting atx mRNA, the embryos showed cardia bifida, a phenotype induced by down-regulation of sphingosine-1-phosphate signaling.

4. the ATX-LPA (Montrer LPA Anticorps)-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates

5. This study demonstrate that the zebrafish ortholog to mammalian atx displays evolutionarily conserved expression pattern characteristics.

6. results suggest a major role for the Atx/Lpar3 (Montrer LPAR3 Anticorps) signaling axis in regulating KV formation, ciliogenesis and L-R asymmetry via a Wnt (Montrer WNT2 Anticorps)-dependent pathway