anti-Elastase, Neutrophil Expressed (ELANE) Anticorps

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. De plus, nous expédions Elastase, Neutrophil Expressed Kits (106) et Elastase, Neutrophil Expressed Protéines (15) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
ELANE 299606  
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Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis in A2058 cell line lysates (35ug/lane) using Neutrophil elastase  Antibody (N-term). This demonstrates this antibody detected the Neutrophil elastase protein (arrow). 0.4 mL Connectez-vous pour afficher 6 to 8 Days
Humain Lapin Inconjugué WB Neutrophil elastase Antibody (N-term) (ABIN656021) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the Neutrophil elastase antibody detected the Neutrophil elastase protein (arrow). 400 μL Connectez-vous pour afficher 10 to 11 Days
Humain Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Human Leukocyte Cells. 100 μg Connectez-vous pour afficher 13 to 16 Days
Chien Lapin Inconjugué FACS, IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Neutrophil Elastase/ELANE Polyclonal Antibody, Unconjugated (ABIN1386058) at 1:200 followed by conjugation to the secondary antibody and DAB staining. A549 cells probed with 	Neutrophil Elastase Polyclonal Antibody, Unconjugated  at 1:100 for 30 minutes followed by incubation with a conjugated secondary -PE) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). 100 μL Connectez-vous pour afficher 3 to 7 Days
Souris Lapin Inconjugué IHC (p), WB   100 μg Connectez-vous pour afficher 4 to 6 Days
Humain Lapin Inconjugué IP, WB Western Blot: Neutrophil Elastase Antibody [NBP2-19524] - Sample (30 ug of whole cell lysate) A: A549 B: HepG2 12% SDS PAGE gel, diluted at 1:1000. Immunoprecipitation: Neutrophil Elastase/ELA2 Antibody  Neutrop. EasyBlot anti-Rabbit IgG was used as a secondary reagent. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
Humain Souris Inconjugué CyTOF, FACS, ICC, IHC, WB Detection of Neutrophil Elastase/ELA2 in THP-1 Human Cell Line by Flow Cytometry. THP-1 human acute monocytic leukemia cell line treated with 3 uM monensin for 3 hours was stained with Mouse Anti-Human Neutrophil Elastase/ELA2 Monoclonal Antibody. Detection of Human Neutrophil Elastase/ELA2 by Western Blot. Western blot shows lysates of human bone marrow and human lung tissue. PVDF membrane was probed with 0.1 ug/mL of Mouse Anti-Human Neutrophil Elastase/ELA2 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Connectez-vous pour afficher 8 to 9 Days
Humain Souris Inconjugué ELISA 200 μL Connectez-vous pour afficher 7 to 9 Days
Humain Souris Inconjugué EIA, Func, FACS   0.2 mg Connectez-vous pour afficher 6 to 8 Days
Humain Mouton Inconjugué IEP, IHC (p), ELISA Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 7 to 9 Days

ELANE Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) , ,
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anti-Elastase, Neutrophil Expressed Anticorps mieux référencés

  1. Dog (Canine) Polyclonal ELANE Primary Antibody pour FACS, IF (p) - ABIN1386058 : Jeffery, Kimura, Gray, Lueth, Bellaire, LeVine: Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. dans Veterinary immunology and immunopathology 2015 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ELANE Primary Antibody pour IA - ABIN2192191 : Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. dans The Journal of infectious diseases 1997 (PubMed)
    Show all 2 Pubmed References

Plus d’anticorps contre Elastase, Neutrophil Expressed partenaires d’interaction

Human Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Plasma Neutrophil Elastase and Elafin (Montrer PI3 Anticorps) as Prognostic Biomarker for Acute Respiratory Distress Syndrome.

  2. Our results suggest that associated serum levels of proMMP-9, NGAL (Montrer LCN2 Anticorps), proMMP-9/NGAL (Montrer LCN2 Anticorps) and NE may reflect the state of systemic inflammation in chronic obstructive pulmonary disease related to cigarette smoking.

  3. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.

  4. Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.

  5. The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (Montrer EIF2AK3 Anticorps) and CHOP (Montrer DDIT3 Anticorps) is reported.

  6. results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (Montrer ELN Anticorps) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy

  7. Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.

  8. Data suggest that neuropilin-1 (NRP1 (Montrer NRP1 Anticorps)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (Montrer TMEM37 Anticorps) (a peptide fragment of NE) in breast cancer cells.

  9. This study proposes that acquisition of CSF3R (Montrer CSF3R Anticorps) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (Montrer SRI Anticorps) patients.

  10. Faecal biomarkers lactoferrin (Montrer LTF Anticorps), calprotectin (Montrer S100A8 Anticorps), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) interaction partners

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (Montrer CEBPA Anticorps)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (Montrer CEBPA Anticorps) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (Montrer F2 Anticorps) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (Montrer APOE Anticorps) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

Elastase, Neutrophil Expressed (ELANE) profil antigène

Profil protéine

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Gene names and symbols associated with ELANE

  • elastase, neutrophil expressed (ELANE) anticorps
  • elastase, neutrophil expressed (Elane) anticorps
  • proteinase 3 (prtn3) anticorps
  • ela2 anticorps
  • ELANE anticorps
  • F430011M15Rik anticorps
  • GE anticorps
  • HLE anticorps
  • HNE anticorps
  • NE anticorps
  • PMN-E anticorps
  • SCN1 anticorps

Protein level used designations for ELANE

PMN elastase , bone marrow serine protease , elastase 2, neutrophil , elastase-2 , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , neutrophil elastase , polymorphonuclear elastase , serine protease , elastase, neutrophil expressed , LOW QUALITY PROTEIN: neutrophil elastase

1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100126050 Bos taurus
100301482 Felis catus
100724414 Cavia porcellus
100522182 Sus scrofa
102173292 Capra hircus
101110841 Ovis aries musimon
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