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Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. De plus, nous expédions EMX1 Anticorps (52) et beaucoup plus de produits pour cette protéine.
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An intersectional fate-mapping analysis reveals that transgenic Emx1-lineage cells coexpressing Dlx exclusively generate medium spiny neurons but do not contribute to the excitatory neurons in the amygdala.
Study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area.
Study shows that in mice on the C57Bl/6 background EMX1 plays an essential role in the midline crossing of an axonal subpopulation of the corpus callosum derived from the anterior cingulate cortex. In the absence of EMX1, cingulate axons display reduced expression of the axon guidance receptor NRP1 and form aberrant axonal bundles within the rostral corpus callosum.
The data of this study confirmed a dorsal precursor origin for cortical EGFR+ precursors and identify a novel regional difference in the abundance of self-renewing, neurogenic precursors within the Emx1-lineage of the late gestation mouse cerebral cortex
These results suggest that the fate of the Emx1-expressing lineage in the ischemic damaged striatum is restricted.
Emx1 knockout mice displayed less anxiety-like behavior in the elevated plus maze and dark/light exploration test and less depression-like response to the forced swimming test. The acoustic startle prepulse inhibition was reduced.
Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double knockout mice
The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development.
Emx1 and Emx2 cooperate in generation of the boundary between the roof and archipallium; these genes develop the archipallium against the roof
analysis of the mouse neocortical subependymal cell origin and the roles of Emx1 and GAD67
Expression levels of Emx1 and Emx2 restrict the prospective embryonic choroid plexus territory.
Our data suggest that deletion of the Emx1 gene reduces hippocampal neurogenesis and affects higher motor function that requires extensive learning.
Emx1 lineage-derived cells contributed a substantial portion of GABAergic cells in the OB, including calretinin+ interneurons. This is in contrast to cortex, in which Emx1 lineage-derived cells do not differentiate into GABAergic neurons.
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
empty spiracles homolog 1
, empty spiracles-like protein 1
, homeobox protein EMX1