Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Kits ELISA

The protein encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. De plus, nous expédions ERAP1 Anticorps (82) et ERAP1 Protéines (7) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ERAP1 51752 Q9NZ08
ERAP1 80898 Q9EQH2
ERAP1 80897 Q9JJ22
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Top ERAP1 Kits ELISA sur anticorps-enligne.fr

Showing 3 out of 7 products:

Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Connectez-vous pour afficher 15 to 18 Days
Souris < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
Rat < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days

Plus Kits ELISA pour ERAP1 partenaires d'interaction

Cow (Bovine) Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against Bovine Tuberculosis.

Human Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) interaction partners

  1. There was a significant association between ERAP1 polymorphisms (rs30187 and rs27037) and increased risk of Ankylosing Spondylitis susceptibility.

  2. ERAP1 gene rs26653 polymorphism may increase the risk of psoriasis vulgaris in Chinese Han population

  3. this study shows the association of ERAP1 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset

  4. ERAP1 and ERAP2 heterodimers have a role in mediating the processing pathway of MHC class I antigens

  5. these results indicated that the ERAP gene may play a critical role in Hepatitis C virus chronicity in Chinese Han population

  6. this study demonstrates associations of ERAP1 coding variants and domain specific interaction with HLA-C *06 in the early onset psoriasis patients of India

  7. To decrease the enzymatic activity of ERAP1.

  8. Data demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs.

  9. these results present the first direct evidence that human disease-associated ERAP1 variants can greatly alter survival, as well as antigen presentation, T-cell repertoire and NK cell responses in vivo in mice

  10. The ERAP1 association with ankylosing spondylitis is predominantly attributable to common ERAP1 haplotypes and haplotype combinations.

  11. these study reports an association of the ERAP1 SNP rs30187 with the HLA-C*07 allele in inflammatory bowel disease in the Spanish population

  12. Study suggests that ERAP1 rs27044 polymorphism may be related to ankylosing spondylitis susceptibility in Chinese Han population.

  13. Segregating according to HLAB27 status did not alter the lack of association. rs30187 SNP in ERAP1 does not confer risk of developing ERA or AS in the Asian Indian population.

  14. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  15. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 and ERAP2 polymorphisms on their enzymatic activity.

  16. The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of ankylosing spondylitis and inflammatory bowel disease. In contrast, IL-23R gene polymorphisms may serve a protective role in ankylosing spondylitis and inflammatory bowel disease.

  17. Our results suggest that normal levels of ERAP1 reduce the accumulation of aberrant and disulfide-linked forms of HLA-B27 in monocytes, and thus help to maintain the integrity of cell surface HLA-B27 complexes.

  18. The alterations in the nature and affinity of HLA-B*51.peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with Behcet's disease.

  19. One ERAP1 protein allotype with five non-ancestral amino acids was recessively associated with Behcet's disease. The ERAP1 association was absent in individuals who lacked HLA-B*51. Individuals who carry HLA-B*51 and who are also homozygous for the haplotype had an increased disease odds compared with those with neither risk factor.

  20. Electrostatic interactions between domains II and IV in ERAP1 are crucial for driving a conformational change that regulates the structural integrity of the catalytic site.

ERAP1 profil antigène

Antigen Summary

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with ERAP1

  • endoplasmic reticulum aminopeptidase 1 (ERAP1) anticorps
  • endoplasmic reticulum aminopeptidase 1 (erap1) anticorps
  • endoplasmic reticulum aminopeptidase 1b (erap1b) anticorps
  • endoplasmic reticulum aminopeptidase 1 (Erap1) anticorps
  • A-LAP anticorps
  • ALAP anticorps
  • Appils anticorps
  • ARTS-1 anticorps
  • Arts1 anticorps
  • DKFZp469C044 anticorps
  • ERAAP anticorps
  • ERAAP1 anticorps
  • MGC166160 anticorps
  • PILS-AP anticorps
  • PILSA anticorps
  • PILSAP anticorps

Protein level used designations for ERAP1

endoplasmic reticulum aminopeptidase 1 , endoplasmic reticulum aminopeptidase 1-like , type 1 tumor necrosis factor receptor shedding aminopeptidase regulator , adipocyte-derived leucine aminopeptidase , aminopeptidase PILS , aminopeptidase regulator of TNFR1 shedding , endoplasmic reticulum aminopeptidase associated with antigen processing , puromycin-insensitive leucyl-specific aminopeptidase , A-LAP , ARTS-1 , PILS-AP , VEGF-induced aminopeptidase , ER-aminopeptidase 1 , leucyl-specific aminopeptidase PILS

427122 Gallus gallus
488898 Canis lupus familiaris
514617 Bos taurus
100010465 Monodelphis domestica
100173512 Pongo abelii
100391536 Callithrix jacchus
100477111 Ailuropoda melanoleuca
100496768 Xenopus (Silurana) tropicalis
100565356 Anolis carolinensis
100602026 Nomascus leucogenys
393175 Danio rerio
471835 Pan troglodytes
699996 Macaca mulatta
100352256 Oryctolagus cuniculus
51752 Homo sapiens
80898 Mus musculus
80897 Rattus norvegicus
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