Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Kits ELISA

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. De plus, nous expédions Endoplasmic Reticulum Aminopeptidase 2 Anticorps (27) et Endoplasmic Reticulum Aminopeptidase 2 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ERAP2 64167 Q6P179
ERAP2 513572 A6QPT7
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Top Endoplasmic Reticulum Aminopeptidase 2 Kits ELISA sur anticorps-enligne.fr

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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.128 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$589.47
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  96 Tests Connectez-vous pour afficher 15 to 18 Days
$1,029.60
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Plus Kits ELISA pour Endoplasmic Reticulum Aminopeptidase 2 partenaires d'interaction

Human Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) interaction partners

  1. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  2. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 (Montrer ERAP1 Kits ELISA) and ERAP2 polymorphisms on their enzymatic activity.

  3. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis.

  4. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 (Montrer ERAP1 Kits ELISA) trimming. These data support the notion of a peptide-media

  5. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus

  6. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  7. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.

  8. ERAP2 is associated with ankylosing spondylitis in HLA-B27 positive and HLA-B27 negative patients.

  9. ERAP2 might be associated with CLNM in PTMC.

  10. ERAP2 variation does not have a significant effect on PBMC intracellular and cell surface HLA-class I (Montrer MICA Kits ELISA) expression and heavy chain formation, markers of ER stress or inflammatory cytokine production.

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) profil antigène

Antigen Summary

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2\; MIM 190470) (Tanioka et al., 2003

Gene names and symbols associated with ERAP2

  • endoplasmic reticulum aminopeptidase 2 (ERAP2) anticorps
  • endoplasmic reticulum aminopeptidase 2 (erap2) anticorps
  • ERAP2 anticorps
  • L-RAP anticorps
  • LRAP anticorps
  • zgc:172163 anticorps

Protein level used designations for ERAP2

leukocyte-derived arginine aminopeptidase , endoplasmic reticulum aminopeptidase 2 , endoplasmic reticulum aminopeptidase 2-like

GENE ID SPECIES
64167 Homo sapiens
461959 Pan troglodytes
513572 Bos taurus
700118 Macaca mulatta
100171433 Pongo abelii
100402550 Callithrix jacchus
100856345 Canis lupus familiaris
100073223 Equus caballus
100525036 Sus scrofa
100144556 Danio rerio
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