anti-Ets Variant 4 (ETV4) Anticorps

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.. De plus, nous expédions ETV4 Protéines (5) et ETV4 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
ETV4 2118 P43268
ETV4 360635  
ETV4 18612  
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Top anti-ETV4 Anticorps sur anticorps-enligne.fr

Showing 10 out of 70 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-ETV4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Small Intestine Host:  Rabbit  Target Name:  ETV4  Sample Tissue:  Human Jurkat Whole Cell  Antibody Dilution:  1ug/ml 100 μL Connectez-vous pour afficher 2 to 3 Days
$319.00
Détails
Humain Lapin Inconjugué WB 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Chien Lapin Inconjugué IHC, WB Immunohistochemical analysis of ETV4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of ETV4 expression in HeLa (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using ETV4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Humain Souris Inconjugué ELISA, WB Figure 1: Western blot analysis using ETV4 mouse mAb against K562 cell lysate (1). Dilution: 1/500 - 1/2000 Figure 2: Western blot analysis using ETV4 mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY ETV4 cDNA (2). Dilution: 1/500 - 1/2000 100 μL Connectez-vous pour afficher 10 to 11 Days
$577.50
Détails
Boeuf (Vache) Lapin Inconjugué IHC, IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with ETV4 antibody ABIN214103 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Skin (formalin-fixed, paraffin-embedded) stained with ETV4 antibody ABIN214103 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Connectez-vous pour afficher 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Western blot analysis of ETV4 antibody (C-term) (ABIN390582) in mouse heart tissue lysates (35 µg/lane). ETV4 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of ETV4 (arrow) using rabbit polyclonal ETV4 Antibody (C-term) (ABIN390582). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ETV4 gene (Lane 2) . 400 μL Connectez-vous pour afficher 10 to 11 Days
$385.00
Détails
Humain Lapin Inconjugué EIA, FACS, IHC (p), WB 0.4 mL Connectez-vous pour afficher 6 to 8 Days
$390.50
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Testis, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Connectez-vous pour afficher 11 to 14 Days
$484.00
Détails
Humain Lapin Inconjugué ELISA, IHC, IHC (p) 100 μL Connectez-vous pour afficher 11 to 14 Days
$493.17
Détails

anti-ETV4 Anticorps mieux référencés

  1. Cow (Bovine) Polyclonal ETV4 Primary Antibody pour WB - ABIN2779533 : Span, Manders, Heuvel, Beex, Sweep: E1AF expression levels are not associated with prognosis in human breast cancer. dans Breast cancer research and treatment 2003 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal ETV4 Primary Antibody pour ELISA, WB - ABIN969121 : Zhu, Jiang, Shen, Wang, Zong, Li, Yang, Niu, Liu, Chen, Hu, Gu: Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. dans The Journal of biological chemistry 2005 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal ETV4 Primary Antibody pour ICC, IF - ABIN4344677 : Wollenick, Hu, Kristiansen, Schraml, Rehrauer, Berchner-Pfannschmidt, Fandrey, Wenger, Stiehl: Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. dans Nucleic acids research 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal ETV4 Primary Antibody pour ELISA, WB - ABIN560805 : Han, Mehra, Dhanasekaran, Yu, Menon, Lonigro, Wang, Gong, Wang, Shankar, Laxman, Shah, Varambally, Palanisamy, Tomlins, Kumar-Sinha, Chinnaiyan: A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer. dans Cancer research 2008 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal ETV4 Primary Antibody pour FACS, IHC (p) - ABIN390582 : Zhang, Yokoyama, Herriges, Zhang, Young, Verheyden, Sun: E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. dans Proceedings of the National Academy of Sciences of the United States of America 2017 (PubMed)

Plus d’anticorps contre ETV4 partenaires d’interaction

Human Ets Variant 4 (ETV4) interaction partners

  1. Data suggested an oncogenic function of ETV4 in pancreatic cancer by demonstrating its increased expression level and its role in growth and cell-cycle progression of pancreatic cancer cells. ETV4-induced cell growth was facilitated by rapid transition of cells from G1- to S-phase of the cell cycle. Mechanistic studies revealed that ETV4 directly regulates the expression of CCND1.

  2. Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis.

  3. Many of the ewing sarcoma family of tumors with negative NKX2.2 immunoreactivity were in bone. Strong/moderate ETV4 nuclear expression was detected in two small round cell tumors

  4. four oncogenic ETS (ERG, ETV1, ETV4, and ETV5), and no other ETS, interact with the Ewing's sarcoma breakpoint protein, EWS.

  5. FOS strongly binds to the same MED25 site as ETV4 activation domain and JUN interacts with the other two MED25 sites.

  6. Our results indicate that assessing AP1 and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 and/or ETV4 causes an OAC cell growth defect

  7. ETV4 overexpression is associated with lung cancer metastasis.

  8. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.

  9. The data provide the molecular details of ETV4-mediated NANOG gene expression.

  10. the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells

  11. NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 domain of NCOA2 and the ETS DNAbinding domain of ETV4.

  12. PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells.

  13. ACC1 and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1/ACLY-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output

  14. ETV4 overexpression is associated with prostate cancer aggressiveness.

  15. molecular mechanism underlying DBC1 function in PEA3-mediated transcription involves inhibition of SIRT1 interaction with PEA3 and of SIRT1-mediated deacetylation of PEA3

  16. Implicate Pea3 as a mediator of liver metastases in colorectal cancer.

  17. Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA/uPAR as well as (MMP)-2 and MMP-9

  18. data suggest that polyomavirus enhancer activator 3 and epithelium-specific transcription factor-1 may play important roles in pluri potent and tumorigenic embryonic carcinoma cells.

  19. developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes

  20. PEA3 regulates OCT4 gene expression as a transcriptional activator

Mouse (Murine) Ets Variant 4 (ETV4) interaction partners

  1. This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.

  2. The E26 transformation-specific transcription factor, ETV4, which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.

  3. Our results will help understand the mechanism of ETV4 overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.

  4. ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.

  5. paracrine signaling via fibroblast growth factor 2 (Fgf2) and Mapk between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.

  6. Study hypothesized that PEA3 might play an essential role in the activation of the FAK gene during tumor metastasis.

  7. Study reveals molecular insight into how the Ets family transcription factor Pea3 favors EMT and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2, a new Pea3 target gene.

  8. oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer

  9. PEA3-null fibroblasts exhibit impaired c-src activation and motility defects.

  10. Smad2 and PEA3 regulate RGC-32 transcription which is essential for smooth muscle cell differentiation from neural crest cells.

  11. study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer

  12. Induction of Pea3 gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons.

  13. PEA3 expression in developing motor neurons is regulated by GDNF signals from the limb bud.

  14. motoneurons innervating the cutaneous maximus muscle, which are normally PEA3(+), fail to develop normally so that postnatally the muscle is innervated by few motoneurons and is severely atrophic

  15. Pea3 is expressed in tissues undergoing branching morphogenesis and promotes formation of duct-like structures by mammary epithelial cells in vitro.

  16. Pea3 subfamily members play a role in epithelial-mesenchymal interactions during lung organogenesis.

  17. pea3 is induced by GDNF in a subset of the motor neurons. Signaling by the HGF receptor (met), is required for rostral expansion of the pea3 domain, while pea3 expression is independent of met function.

  18. Beta-catenin, Lef-1, Ets transcription factors, and the AP-1 protein c-Jun each weakly enhanced luciferase expression from an OPN promoter.

  19. ETS-1, PEA3, and ERM have roles in regulation of caveolin-1 transcription in epithelial cells

  20. We provide genetic evidence that the induction of the ETS transcription factor Pea3 by GDNF is essential in two cervical MN pools to control dendrite patterning and selectivity of IaPA connectivity.

Zebrafish Ets Variant 4 (ETV4) interaction partners

  1. etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development

  2. Pea3 and erm are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.

  3. Overlapping functions of pea3 ETS transcription factors in FGF signaling during zebrafish development are reported.

ETV4 profil antigène

Profil protéine

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'GT-3'.

Gene names and symbols associated with anti-Ets Variant 4 (ETV4) Anticorps

  • ETS variant 4 (ETV4) anticorps
  • ets variant 4 (Etv4) anticorps
  • ets variant 4 (etv4) anticorps
  • AW414408 anticorps
  • E1A-F anticorps
  • E1AF anticorps
  • Pea-3 anticorps
  • pea3 anticorps
  • PEAS3 anticorps

Protein level used designations for anti-Ets Variant 4 (ETV4) Anticorps

ETS translocation variant 4 , EWS protein/E1A enhancer binding protein chimera , adenovirus E1A enhancer-binding protein , ets variant gene 4 (E1A enhancer-binding protein, E1AF) , polyomavirus enhancer activator 3 homolog , ets variant gene 4 (E1A enhancer binding protein, E1AF) , polyomavirus enhancer activator-3 , ets domain protein , ETS variant protein 4 , POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4) , ETS translocation variant 4-like , ETS domain-containing transcription factor PEA3 , ETS-domain transcription factor pea3 , etID309954.12

GENE ID SPECIES
2118 Homo sapiens
360635 Rattus norvegicus
395747 Gallus gallus
454715 Pan troglodytes
100065121 Equus caballus
403641 Canis lupus familiaris
18612 Mus musculus
533129 Bos taurus
30700 Danio rerio
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