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EIF1AX encodes an essential eukaryotic translation initiation factor. De plus, nous expédions EIF1AX Protéines (10) et et beaucoup plus de produits pour cette protéine.
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Human Polyclonal EIF1AX Primary Antibody pour WB - ABIN4307538
Dobrikov, Shveygert, Brown, Gromeier: Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. dans Molecular and cellular biology 2014
Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 (Montrer EIF2C2 Anticorps) and functions in DICER (Montrer DICER1 Anticorps)-independent miRNA biogenesis and miRNA-mediated RNA interference.
EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%).
Coexpression of mutant NRAS (Montrer NRAS Anticorps) and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.
Short 5'UTR (Montrer UTS2R Anticorps) mRNAs are enriched with TISU (translation initiator of short 5'UTR (Montrer UTS2R Anticorps)), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (Montrer EIF4G1 Anticorps) 1A (eIF1A) which interacts with both RPS3 (Montrer RPS3 Anticorps) and RPS10e.
Mutation in EIF1AX gene is associated with Uveal Melanoma.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (Montrer GNAQ Anticorps), GNA11 (Montrer GNA11 Anticorps), and EIF1AX mutations.
results indicate that the interactions between eIF1A and eIF5B (Montrer EIF5B Anticorps) are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B (Montrer EIF5B Anticorps) interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1 (Montrer RNF2 Anticorps), SF3B1 (Montrer SF3B2 Anticorps), or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1 (Montrer SF3B2 Anticorps)-mutated tumors are associated with late metastasis
BAP1 (Montrer RNF2 Anticorps), SF3B1 (Montrer SF3B2 Anticorps), and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.
We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules.
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
Putative eukaryotic translation initiation factor 1A
, eIF-1A X isoform
, eukaryotic translation initiation factor 1A, X chromosome
, eukaryotic translation initiation factor 1A, X-chromosomal
, eukaryotic translation initiation factor 4C
, eukaryotic translation initiation factor 1A, Y-linked