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Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. De plus, nous expédions EIF4G2 Protéines (4) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 116 products:
Human Polyclonal EIF4G2 Primary Antibody pour WB - ABIN1944751
Imataka, Olsen, Sonenberg: A new translational regulator with homology to eukaryotic translation initiation factor 4G. dans The EMBO journal 1997
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Human Monoclonal EIF4G2 Primary Antibody pour FACS, WB - ABIN265943
Levy-Strumpf, Deiss, Berissi, Kimchi: DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. dans Molecular and cellular biology 1997
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Human Monoclonal EIF4G2 Primary Antibody pour IHC (p), ELISA - ABIN560721
Katsogiannou, Andrieu, Baylot, Baudot, Dusetti, Gayet, Finetti, Garrido, Birnbaum, Bertucci, Brun, Rocchi: The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. dans Molecular & cellular proteomics : MCP 2014
The percentage at the S-stage was decreased in the miR (Montrer MLXIP Anticorps)-379 mimics and EIF4G2 shRNA groups.
DAP5 knockdown from human ESCs (Montrer NR2E3 Anticorps) (hESCs) resulted in persistence of pluripotent gene expression, delayed induction of differentiation-associated genes in different cell lineages, and defective embryoid body formation
Data show that microRNA miR (Montrer MLXIP Anticorps)-379 potentiated lung cancer (LCa (Montrer CLTA Anticorps)) chemosensitivity via modulation of cisplatin (CDDP)-induced apoptosis by directly targeting the eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) 3' UTR (Montrer UTS2R Anticorps).
These results indicate that miR (Montrer MLXIP Anticorps)-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR (Montrer MLXIP Anticorps)-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R (Montrer IGF1R Anticorps).
The Coxsackievirus B3 protease 2A-mediated cleavage of DAP5 results in the production of two truncates that exert differential effects on protein translation of the IRES-containing genes, leading to enhanced host cell death.
Knockdown of EIF4G2 recapitulated the effects of mir (Montrer MLXIP Anticorps)-139, whereas restoring EIF4G2 expression rescued the mir (Montrer MLXIP Anticorps)-139 phenotype. elevated miR (Montrer MLXIP Anticorps)-139-5p expression is associated with a favorable outcome in acute myeloid leukemia (Montrer BCL11A Anticorps).
findings provide the first mechanistic insights into the function of DAP5 as a selective regulator of cap-independent translation
Our results provide evidence that the tumor suppressor effect of miR (Montrer MLXIP Anticorps)-520c-3p is mediated through repression of translation while inducing senescence and that eIF4GII (Montrer EIF4G3 Anticorps) is a key effector of this anti-tumor activity.
DAP5, a translation initiation factor shown to positively regulate the translation of various internal ribosome entry sites containing mRNAs, promotes internal ribosome entry site-driven translation of p53 (Montrer TP53 Anticorps) mRNA.
DAP5/p97 and DAP5/p86 enhanced the translation of the anti-apoptotic protein Bcl-2 (Montrer BCL2 Anticorps) and inhibited cisplatin-induced apoptosis
analysis of the tandem MA-3 (Montrer PDCD6 Anticorps) region of Pdcd4 (Montrer PDCD4 Anticorps) protein and characterization of its interactions with eIF4A (Montrer EIF4A1 Anticorps) and eIF4G (Montrer EIF4G1 Anticorps)
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3\; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
eukaryotic translation initiation factor 4 gamma, 2
, eukaryotic translation initiation factor 4 gamma 2
, Eukaryotic translation initiation factor 4 gamma 2
, aging-associated protein 1
, death-associated protein 5
, eIF-4-gamma 2
, eIF-4G 2
, eIF4G 2
, eukaryotic translation initiation factor 4G-like 1
, eIF4G-related protein NAT1
, novel APOBEC-1 target 1
, translation repressor NAT1
, translation repressor Nat1