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EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008].. De plus, nous expédions EIF4E3 Protéines (6) et et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal EIF4E3 Primary Antibody pour WB - ABIN2776663
Yi, Papadopoulos, Hagner, Wagner: Hypoxia-inducible factor-1? (HIF-1?) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. dans The Journal of biological chemistry 2013
We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.
Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules.
MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma.
eIF4E3 impedes oncogenic transformation and its expression is lost in some cancers.
eIF4E3 specifically binds the m(7)G cap in the absence of an aromatic sandwich, using instead a different spatial arrangement of residues to provide the necessary electrostatic and van der Waals contacts.
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004
eukaryotic translation initiation factor 4E family member 3
, eukaryotic translation initiation factor 4E type 3
, eIF4E type 3
, eIF-4E type 3
, eukaryotic translation initiation factor 4E member 3
, eukaryotic translation initiation factor 4E class III
, eIF-4E type 3-B
, eIF4E type 3-B
, eukaryotic translation initiation factor 4E type 3-B
, eukaryotic translation initiation factor-3