Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like Protéines (ERCC6L)

DNA helicase that acts as an essential component of the spindle assembly checkpoint. De plus, nous expédions Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like Anticorps (51) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ERCC6L 54821 Q2NKX8
ERCC6L 236930 Q8BHK9
Rat ERCC6L ERCC6L 317252  
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Top Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like Protéines sur anticorps-enligne.fr

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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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ERCC6L Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L) partenaires d'interaction

Human Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L) interaction partners

  1. These findings suggested that ERCC6L, which is highly expressed in breast cancer, acts as an oncogene, is involved in breast cancer development and may serve as a novel molecular target for the treatment of breast cancer.

  2. ERCC6L may stimulates cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2, and it could be a potential biomarker for cancer prognosis and target for cancer treatment.

  3. Data indicate BEND3 as a new interaction partner for PICH in mitosis, and have defined the residues within a TPR-BEN domain interface that mediate this interaction.

  4. Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex has been reported.

  5. the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the ribosomal DNA locus, are reported.

  6. a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported.

  7. PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis.

  8. PICH is a SUMO-interacting protein and a mitotic SUMO substrate.

  9. PICH recognizes and stabilizes DNA under tension during anaphase, thereby facilitating the resolution of entangled sister chromatids.

  10. PICH protein was required for the correct recruitment to the centromere of active topoisomerase IIalpha, an enzyme specialized in the catenation/decatenation process.

  11. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.

  12. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture

  13. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 transcript and protein.

  14. These data identify PICH as a novel essential component of checkpoint signaling.

  15. The sensitivity to depletion of topo IIalpha might be linked to structural alterations within the centromere domain, indicated by shortening of the distance across metaphase sister centromeres and persistence of PICH-coated connections.

  16. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms.

  17. Functional characterization of the mouse Ercc6l ortholog.

Profil protéine Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L)

Profil protéine

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.

Gene names and symbols associated with ERCC6L

  • ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L)
  • excision repair cross-complementing rodent repair deficiency complementation group 6 like (Ercc6l)
  • ERCC excision repair 6 like, spindle assembly checkpoint helicase (Ercc6l)
  • DNA excision repair protein ERCC-6-like (LOC100373376)
  • DNA excision repair protein ERCC-6-like (LOC100494766)
  • DNA excision repair protein ERCC-6-like (LOC100552957)
  • DNA excision repair protein ERCC-6-like (LOC100560751)
  • DNA excision repair protein ERCC-6-like (LOC100563247)
  • excision repair cross-complementation group 6-like (ercc6l)
  • BC004701 Protéine
  • D330021P09Rik Protéine
  • fc22h03 Protéine
  • PICH Protéine
  • RAD26L Protéine
  • RGD1565734 Protéine
  • si:ch211-278b8.3 Protéine
  • wu:fc22h03 Protéine

Protein level used designations for ERCC6L

ATP-dependent helicase ERCC6-like , DNA excision repair protein ERCC-6-like , Plk1-interacting checkpoint helicase , SNF2/RAD54 family protein , excision repair cross-complementing rodent repair deficiency complementation group 6 - like , excision repair protein ERCC6-like , tumor antigen BJ-HCC-15 , excision repair cross-complementing rodent repair deficiency complementation group 6-like , excision repair cross-complementing rodent repair deficiency, complementation group 6-like

GENE ID SPECIES
54821 Homo sapiens
236930 Mus musculus
317252 Rattus norvegicus
782916 Bos taurus
100020004 Monodelphis domestica
100373376 Saccoglossus kowalevskii
100432874 Pongo abelii
100479265 Ailuropoda melanoleuca
100494766 Xenopus (Silurana) tropicalis
100552957 Anolis carolinensis
100560751 Anolis carolinensis
100563247 Anolis carolinensis
100584141 Nomascus leucogenys
100622071 Sus scrofa
100052221 Equus caballus
100005291 Danio rerio
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