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EXOSC9 encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. De plus, nous expédions EXOSC9 Protéines (9) et EXOSC9 Kits (2) et beaucoup plus de produits pour cette protéine.
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Chicken Polyclonal EXOSC9 Primary Antibody pour ChIP, ICC - ABIN4309778
McIver, Katsumura, Davids, Liu, Kang, Yang, Bresnick: Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis. dans eLife 2016
Show all 3 Pubmed References
Human Polyclonal EXOSC9 Primary Antibody pour ELISA, WB - ABIN449851
Schilders, Raijmakers, Malmegrim, Vande Walle, Saelens, Vree Egberts, van Venrooij, Vandenabeele, Pruijn: Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. dans Arthritis research & therapy 2007
inactivation of both exosc9, which encodes a component of the RNA exosome, and ptbp1, which encodes an RNA-binding protein abundant in Xenopus embryonic skin, impairs embryonic Xenopus skin development.
variants in EXOSC9 result in a neurological syndrome combining cerebellar atrophy and spinal motoneuronopathy, thus expanding the list of human exosomopathies.
Although not required for exosome stability, PM/Scl-100 and PM/Scl-75 are involved in mRNA degradation.
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements, possibly by direct binding of PM/Scl-75 to these RNA regions.
PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome.
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
, exosome complex exonuclease RRP45
, exosome component 9
, exosome complex exonuclease RRP45-like
, polymyositis/scleroderma autoantigen 1
, P75 polymyositis-scleroderma overlap syndrome associated autoantigen
, P75 polymyositis-scleroderma overlap syndrome-associated autoantigen
, PMSCL autoantigen, 75kD
, autoantigen PM/Scl 1
, exosome complex component RRP45
, polymyositis/scleroderma autoantigen 1, 75kDa
, polymyositis/scleroderma autoantigen 75 kDa